PMID- 29223808
OWN - NLM
STAT- MEDLINE
DCOM- 20181113
LR  - 20181113
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 111
DP  - 2018 Feb
TI  - Perfluoroalkyl acid levels in first-time mothers in relation to offspring weight 
      gain and growth.
PG  - 191-199
LID - S0160-4120(17)30991-1 [pii]
LID - 10.1016/j.envint.2017.12.002 [doi]
AB  - We investigated if maternal body burdens of perfluoroalkyl acids (PFAAs) at the 
      time of delivery are associated with birth outcome and if early life exposure (in 
      utero/nursing) is associated with early childhood growth and weight gain. 
      Maternal PFAA body burdens were estimated by analysis of serum samples from 
      mothers living in Uppsala County, Sweden (POPUP), sampled three weeks after 
      delivery between 1996 and 2011. Data on child length and weight were collected 
      from medical records and converted into standard deviation scores (SDS). Multiple 
      linear regression models with appropriate covariates were used to analyze 
      associations between maternal PFAA levels and birth outcomes (n=381). After birth 
      Generalized Least Squares models were used to analyze associations between 
      maternal PFAA and child growth (n=200). Inverse associations were found between 
      maternal levels of perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), 
      and perfluoroundecanoic acid (PFUnDA), and birth weight SDS with a change of 
      -0.10 to -0.18 weight SDS for an inter-quartile range (IQR) increase in ng/g 
      PFAA. After birth, weight and length SDS were not significantly associated with 
      maternal PFAA. However, BMI SDS was significantly associated with PFOA, PFNA, and 
      PFHxS at 3 and 4years of age, and with PFOS at 4 and 5years of age. If causal, 
      these associations suggest that PFAA affects fetal and childhood body development 
      in different directions.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Gyllenhammar, Irina
AU  - Gyllenhammar I
AD  - National Food Agency, P.O. Box 622, 751 26 Uppsala, Sweden. Electronic address: 
      Irina.gyllenhammar@slv.se.
FAU - Diderholm, Barbro
AU  - Diderholm B
AD  - Department of Women's and Children's Health, Uppsala University, 751 85 Uppsala, 
      Sweden.
FAU - Gustafsson, Jan
AU  - Gustafsson J
AD  - Department of Women's and Children's Health, Uppsala University, 751 85 Uppsala, 
      Sweden.
FAU - Berger, Urs
AU  - Berger U
AD  - Department of Environmental Science and Analytical Chemistry (ACES), Stockholm 
      University, 106 91 Stockholm, Sweden; Department Analytical Chemistry, Helmholtz 
      Centre for Environmental Research - UFZ, 04318 Leipzig, Germany.
FAU - Ridefelt, Peter
AU  - Ridefelt P
AD  - Department of Medical Sciences, Clinical Chemistry, Uppsala University, 751 85 
      Uppsala, Sweden.
FAU - Benskin, Jonathan P
AU  - Benskin JP
AD  - Department of Environmental Science and Analytical Chemistry (ACES), Stockholm 
      University, 106 91 Stockholm, Sweden.
FAU - Lignell, Sanna
AU  - Lignell S
AD  - National Food Agency, P.O. Box 622, 751 26 Uppsala, Sweden.
FAU - Lampa, Erik
AU  - Lampa E
AD  - UCR Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
FAU - Glynn, Anders
AU  - Glynn A
AD  - National Food Agency, P.O. Box 622, 751 26 Uppsala, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171220
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fatty Acids)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Adult
MH  - Alkanesulfonic Acids/*blood
MH  - Birth Weight
MH  - *Child Development
MH  - Environmental Pollutants/*blood
MH  - Fatty Acids/*blood
MH  - Female
MH  - Fluorocarbons/*blood
MH  - Humans
MH  - Infant, Newborn
MH  - Linear Models
MH  - Male
MH  - Mothers
MH  - Multivariate Analysis
MH  - Sweden
MH  - Weight Gain
MH  - Young Adult
EDAT- 2017/12/11 06:00
MHDA- 2018/11/14 06:00
CRDT- 2017/12/11 06:00
PHST- 2017/06/02 00:00 [received]
PHST- 2017/11/27 00:00 [revised]
PHST- 2017/12/01 00:00 [accepted]
PHST- 2017/12/11 06:00 [pubmed]
PHST- 2018/11/14 06:00 [medline]
PHST- 2017/12/11 06:00 [entrez]
AID - S0160-4120(17)30991-1 [pii]
AID - 10.1016/j.envint.2017.12.002 [doi]
PST - ppublish
SO  - Environ Int. 2018 Feb;111:191-199. doi: 10.1016/j.envint.2017.12.002. Epub 2017 
      Dec 20.