PMID- 29224666 OWN - NLM STAT- MEDLINE DCOM- 20180430 LR - 20181202 IS - 1878-1594 (Electronic) IS - 1521-690X (Linking) VI - 31 IP - 6 DP - 2017 Dec TI - Central and peripheral roles of vasopressin in the circadian defense of body hydration. PG - 535-546 LID - S1521-690X(17)30111-2 [pii] LID - 10.1016/j.beem.2017.11.001 [doi] AB - Vasopressin is a neuropeptide synthesized by specific subsets of neurons within the eye and brain. Studies in rats and mice have shown that vasopressin produced by magnocellular neurosecretory cells (MNCs) that project to the neurohypophysis is released into the blood circulation where it serves as an antidiuretic hormone to promote water reabsorption from the kidney. Moreover vasopressin is a neurotransmitter and neuromodulator that contributes to time-keeping within the master circadian clock (i.e. the suprachiasmatic nucleus, SCN) and is also used as an output signal by SCN neurons to direct centrally mediated circadian rhythms. In this chapter, we review recent cellular and network level studies in rodents that have provided insight into how circadian rhythms in vasopressin mediate changes in water intake behavior and renal water conservation that protect the body against dehydration during sleep. CI - Copyright (c) 2017 Elsevier Ltd. All rights reserved. FAU - Gizowski, Claire AU - Gizowski C AD - Center for Research in Neuroscience, Research Institute of the McGill University Health Center, 1650 Cedar Avenue, Montreal, QC, H3G1A4, Canada. Electronic address: cgizowski@gmail.com. FAU - Trudel, Eric AU - Trudel E AD - Center for Research in Neuroscience, Research Institute of the McGill University Health Center, 1650 Cedar Avenue, Montreal, QC, H3G1A4, Canada. Electronic address: trud1000@hotmail.com. FAU - Bourque, Charles W AU - Bourque CW AD - Center for Research in Neuroscience, Research Institute of the McGill University Health Center, 1650 Cedar Avenue, Montreal, QC, H3G1A4, Canada. Electronic address: charles.bourque@mcgill.ca. LA - eng GR - FDN 143337/CIHR/Canada PT - Journal Article PT - Review DEP - 20171113 PL - Netherlands TA - Best Pract Res Clin Endocrinol Metab JT - Best practice & research. Clinical endocrinology & metabolism JID - 101120682 RN - 0 (AVP protein, human) RN - 0 (Neurophysins) RN - 0 (Protein Precursors) RN - 11000-17-2 (Vasopressins) SB - IM MH - Animals MH - Central Nervous System/drug effects/physiology MH - Circadian Rhythm/*physiology MH - Drinking Behavior/drug effects/physiology MH - Humans MH - Mice MH - Neurons/drug effects/metabolism MH - Neurophysins/physiology MH - Organism Hydration Status/drug effects/*physiology MH - Protein Precursors/physiology MH - Rats MH - Suprachiasmatic Nucleus/physiology MH - Vasopressins/metabolism/pharmacology/*physiology OTO - NOTNLM OT - neurohypophysis OT - osmoregulation OT - suprachiasmatic nucleus OT - supraoptic nucleus OT - thirst OT - vasopressin EDAT- 2017/12/12 06:00 MHDA- 2018/05/01 06:00 CRDT- 2017/12/12 06:00 PHST- 2017/12/12 06:00 [entrez] PHST- 2017/12/12 06:00 [pubmed] PHST- 2018/05/01 06:00 [medline] AID - S1521-690X(17)30111-2 [pii] AID - 10.1016/j.beem.2017.11.001 [doi] PST - ppublish SO - Best Pract Res Clin Endocrinol Metab. 2017 Dec;31(6):535-546. doi: 10.1016/j.beem.2017.11.001. Epub 2017 Nov 13.