PMID- 29224935
OWN - NLM
STAT- MEDLINE
DCOM- 20190215
LR  - 20220321
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Linking)
VI  - 195
DP  - 2018 Apr
TI  - Infliximab for the Treatment of Refractory Kawasaki Disease: A Nationwide Survey 
      in Japan.
PG  - 115-120.e3
LID - S0022-3476(17)31362-8 [pii]
LID - 10.1016/j.jpeds.2017.10.013 [doi]
AB  - OBJECTIVE: To assess the safety and efficacy of infliximab (IFX) for the 
      treatment of patients with Kawasaki disease (KD). STUDY DESIGN: This was a 
      nationwide survey of 274 Japanese institutions exploring how IFX was used to 
      treat patients with KD. The patients' sex, age, treatment course, pre- and 
      post-IFX therapy blood test results, coronary artery lesions (CALs), and adverse 
      events (AEs) were evaluated. RESULTS: We analyzed 434 patients with KD who 
      received IFX between March 2005 and November 2014. The median age at onset was 33 
      months (range 1-138), and 66 patients (15.2%) were under 1 year old. In all 
      cases, IFX was administered as additional treatment. The median days of illness 
      at the initiation of IFX was 9 days. In 275 patients (63.4%), IFX was 
      administered as third-line treatment, and in 106 patients (24.4%), IFX was 
      administered as fourth-line treatment. Single dose IFX 5 mg/kg was administered 
      to 412 patients (94.9%). After IFX, 363 patients (83.6%) became afebrile within 2 
      days, and the white blood cell count, percentage of neutrophils, and serum 
      C-reactive protein levels significantly decreased (P < .001), although 119 
      patients (27.4%) received additional treatment. Before IFX, 132 patients (30.4%) 
      had already developed CALs. In patients without CALs before IFX, 31 patients 
      (10.3%) newly developed CAL after IFX, whereas 32 patients (24.2%) with CAL 
      before IFX showed increased CAL severity. Eighty AEs were observed in 69 patients 
      (15.9%); however, serious AEs were few and reversible. CONCLUSIONS: IFX might be 
      an effective and tolerable treatment for refractory KD.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Masuda, Hiroshi
AU  - Masuda H
AD  - Department of General Pediatrics and Interdisciplinary Medicine, National Center 
      for Child Health and Development, Setagaya-ku, Tokyo, Japan; Department of 
      Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, 
      Kanagawa, Japan.
FAU - Kobayashi, Tohru
AU  - Kobayashi T
AD  - Division of Clinical Research Planning, Department of Development Strategy, 
      Center for Clinical Research and Development, National Center for Child Health 
      and Development, Setagaya-ku, Tokyo, Japan. Electronic address: 
      torukoba@nifty.com.
FAU - Hachiya, Akira
AU  - Hachiya A
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Nagano, Japan.
FAU - Nakashima, Yasutaka
AU  - Nakashima Y
AD  - Department of Pediatrics, Graduate School of Medical Sciences, Kyusyu University, 
      Fukuoka, Fukuoka, Japan.
FAU - Shimizu, Hiroyuki
AU  - Shimizu H
AD  - Children's Medical Center, Yokohama City University Medical Center, Yokohama, 
      Kanagawa, Japan.
FAU - Nozawa, Tomo
AU  - Nozawa T
AD  - Department of Pediatrics, Graduate School of Medicine, Yokohama City University, 
      Yokohama, Kanagawa, Japan.
FAU - Ogihara, Yoshihito
AU  - Ogihara Y
AD  - Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, 
      Kanagawa, Japan.
FAU - Ito, Shuichi
AU  - Ito S
AD  - Department of Pediatrics, Graduate School of Medicine, Yokohama City University, 
      Yokohama, Kanagawa, Japan; Division of Pediatric Nephrology and Rheumatology, 
      National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
FAU - Takatsuki, Shinichi
AU  - Takatsuki S
AD  - Department of Pediatrics, Toho University, Medical Center Omori Hospital, Ota-ku, 
      Tokyo, Japan.
FAU - Katsumata, Nobuyuki
AU  - Katsumata N
AD  - Department of Pediatrics, Faculty of Medicine University of Yamanashi, Chuo, 
      Yamanashi, Japan.
FAU - Suzuki, Yasuo
AU  - Suzuki Y
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, 
      Yamaguchi, Japan.
FAU - Takenaka, Satoshi
AU  - Takenaka S
AD  - Department of Pediatrics, Japan Community Healthcare Organization (JCHO), Kyusyu 
      Hospital, Kitakyushu, Fukuoka, Japan.
FAU - Hirono, Keiichi
AU  - Hirono K
AD  - Department of Pediatrics, Graduate School of Medicine, University of Toyama, 
      Toyama, Toyama, Japan.
FAU - Kobayashi, Tomio
AU  - Kobayashi T
AD  - Division of Cardiology, Gunma Children's Medical Center, Shibukawa, Gunma, Japan.
FAU - Suzuki, Hiroshi
AU  - Suzuki H
AD  - Department of Pediatrics, Yamagata University School of Medicine, Yamagata, 
      Yamagata, Japan.
FAU - Suganuma, Eisuke
AU  - Suganuma E
AD  - Division of Infectious Diseases and Immunology, Saitama Children's Medical 
      Center, Saitama, Saitama, Japan.
FAU - Takahashi, Kei
AU  - Takahashi K
AD  - Department of Pathology, Toho University Ohashi Medical Center, Shibuya-ku, 
      Tokyo, Japan.
FAU - Saji, Tsutomu
AU  - Saji T
AD  - Advanced and Integrated Cardiovascular Research Course in the Young and 
      Adolescence, Ota-ku, Toho University, Tokyo, Japan.
CN  - Committee of Survey on Infliximab use for Kawasaki disease
AD  - Japan Society of Kawasaki Disease, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20171207
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 0 (Antirheumatic Agents)
RN  - B72HH48FLU (Infliximab)
SB  - IM
CIN - J Pediatr. 2018 Apr;195:11-13.e1. PMID: 29395176
MH  - Antirheumatic Agents/*administration & dosage
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infliximab/*administration & dosage
MH  - Japan
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/*drug therapy
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
MH  - Time Factors
OTO - NOTNLM
OT  - Kawasaki disease
OT  - coronary artery lesions
OT  - infliximab
OT  - intravenous immunoglobulin
FIR - Matsuzaki, Satoshi
IR  - Matsuzaki S
IRAD- Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Nagano, Japan.
FIR - Yamazaki, Shoko
IR  - Yamazaki S
IRAD- Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Nagano, Japan.
FIR - Ikeda, Kazuyuki
IR  - Ikeda K
IRAD- Department of Pediatrics, Graduate School of Medical Sciences, Kyusyu University, 
      Fukuoka, Fukuoka, Japan.
FIR - Hara, Takuma
IR  - Hara T
IRAD- Children's Medical Center, Yokohama City University Medical Center, Yokohama, 
      Kanagawa, Japan.
FIR - Kanetaka, Taichi
IR  - Kanetaka T
IRAD- Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Nagano, Japan.
FIR - Kizawa, Toshitaka
IR  - Kizawa T
IRAD- Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Nagano, Japan.
FIR - Kikuchi, Masako
IR  - Kikuchi M
IRAD- Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Nagano, Japan.
FIR - Hara, Ryoki
IR  - Hara R
IRAD- Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Nagano, Japan.
FIR - Fujii, Kentaro
IR  - Fujii K
IRAD- Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Nagano, Japan.
FIR - Takahashi, Mayu
IR  - Takahashi M
IRAD- Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Nagano, Japan.
FIR - Sonoda, Kaori
IR  - Sonoda K
IRAD- Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Nagano, Japan.
FIR - Yoshihashi, Tomokuni
IR  - Yoshihashi T
IRAD- Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Nagano, Japan.
FIR - Imagawa, Tomoyuki
IR  - Imagawa T
IRAD- Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Nagano, Japan.
FIR - Yamazaki, Kazuko
IR  - Yamazaki K
IRAD- Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Nagano, Japan.
FIR - Ebato, Takasuke
IR  - Ebato T
IRAD- Division of Pediatric Nephrology and Rheumatology, National Center for Child 
      Health and Development, Setagaya-ku, Tokyo, Japan.
FIR - Oana, Shinji
IR  - Oana S
IRAD- Department of General Pediatrics and Interdisciplinary Medicine, National Center 
      for Child Health and Development, Setagaya-ku, Tokyo, Japan.
FIR - Murase, Ayako
IR  - Murase A
IRAD- Department of General Pediatrics and Interdisciplinary Medicine, National Center 
      for Child Health and Development, Setagaya-ku, Tokyo, Japan.
FIR - Sakaki, Shinichiro
IR  - Sakaki S
IRAD- Department of General Pediatrics and Interdisciplinary Medicine, National Center 
      for Child Health and Development, Setagaya-ku, Tokyo, Japan.
FIR - Fujimoto, Takeshi
IR  - Fujimoto T
IRAD- Department of General Pediatrics and Interdisciplinary Medicine, National Center 
      for Child Health and Development, Setagaya-ku, Tokyo, Japan.
FIR - Saito, Yoshihiko
IR  - Saito Y
IRAD- Department of General Pediatrics and Interdisciplinary Medicine, National Center 
      for Child Health and Development, Setagaya-ku, Tokyo, Japan.
FIR - Shirai, Ryota
IR  - Shirai R
IRAD- Department of General Pediatrics and Interdisciplinary Medicine, National Center 
      for Child Health and Development, Setagaya-ku, Tokyo, Japan.
FIR - Takeuchi, Ichiro
IR  - Takeuchi I
IRAD- Department of General Pediatrics and Interdisciplinary Medicine, National Center 
      for Child Health and Development, Setagaya-ku, Tokyo, Japan.
FIR - Naoi, Kazuyuki
IR  - Naoi K
IRAD- Department of Pediatrics, Toho University, Medical Center Omori Hospital, Ota-ku, 
      Tokyo, Japan.
FIR - Kenmotsu, Yasushi
IR  - Kenmotsu Y
IRAD- Department of Pediatrics, Toho University, Medical Center Omori Hospital, Ota-ku, 
      Tokyo, Japan.
FIR - Goto, Chiaki
IR  - Goto C
IRAD- Department of Pediatrics, Toho University, Medical Center Omori Hospital, Ota-ku, 
      Tokyo, Japan.
FIR - Kise, Hiroaki
IR  - Kise H
IRAD- Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Chuo, 
      Yamanashi, Japan.
FIR - Okada, Seigo
IR  - Okada S
IRAD- Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, 
      Yamaguchi, Japan.
FIR - Kishimoto, Sayuri
IR  - Kishimoto S
IRAD- Department of Pediatrics, Japan Community Healthcare Organization (JCHO), Kyusyu 
      Hospital, Kitakyushu, Fukuoka, Japan.
FIR - Oba, Utako
IR  - Oba U
IRAD- Department of Pediatrics, Japan Community Healthcare Organization (JCHO), Kyusyu 
      Hospital, Kitakyushu, Fukuoka, Japan.
FIR - Ozawa, Sayaka
IR  - Ozawa S
IRAD- Department of Pediatrics, Graduate School of Medicine, University of Toyama, 
      Toyama, Toyama, Japan.
FIR - Seki, Mitsuru
IR  - Seki M
IRAD- Division of Cardiology, Gunma Children's Medical Center, Shibukawa, Gunma, Japan.
FIR - Odagiri, Tesshu
IR  - Odagiri T
IRAD- Department of Pediatrics, Yamagata University School of Medicine, Yamagata, 
      Yamagata, Japan.
FIR - Shiono, Junko
IR  - Shiono J
IRAD- Division of Cardiology, Ibaraki Children's Hospital, Mito, Japan.
FIR - Nagumo, Kiyoshi
IR  - Nagumo K
IRAD- Department of Pediatrics, Teine Keijinkai Hospital, Sapporo, Hokkaido, Japan.
FIR - Kimura, Mitsuaki
IR  - Kimura M
IRAD- Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital, 
      Shizuoka, Shizuoka, Japan.
FIR - Yoshibayashi, Muneo
IR  - Yoshibayashi M
IRAD- Department of Pediatrics, Kindai University Nara Hospital, Ikoma, Nara, Japan.
FIR - Horita, Norihisa
IR  - Horita N
IRAD- Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, 
      Hokkaido, Japan.
FIR - Tsuboi, Tatsuo
IR  - Tsuboi T
IRAD- Department of Pediatrics, Dokkyo Medical University School of Medicine, 
      Mibu-machi, Shimotsuga-gun, Tochigi, Japan.
FIR - Matsubara, Tomoyo
IR  - Matsubara T
IRAD- Department of Pediatrics, Juntendo University Urayasu Hospital, Urayasu, Chiba, 
      Japan.
FIR - Hara, Satoshi
IR  - Hara S
IRAD- Department of Pediatrics, Juntendo University Urayasu Hospital, Urayasu, Chiba, 
      Japan.
FIR - Ishii, Taku
IR  - Ishii T
IRAD- Department of Pediatrics, Tokyo Medical And Dental University Hospital Faculty of 
      Medicine, Bunkyo-ku, Tokyo, Japan.
FIR - Hosokawa, Susumu
IR  - Hosokawa S
IRAD- Department of Pediatrics, Tokyo Medical And Dental University Hospital Faculty of 
      Medicine, Bunkyo-ku, Tokyo, Japan.
FIR - Kishi, Takayuki
IR  - Kishi T
IRAD- Department of Pediatrics, Tokyo Women's Medical University Hospital, Shinjuku-ku, 
      Tokyo, Japan.
FIR - Fukazawa, Ryuji
IR  - Fukazawa R
IRAD- Department of Pediatrics, Nippon Medical School Hospital, Bunkyo-ku, Tokyo, 
      Japan.
FIR - Ogawa, Shunichi
IR  - Ogawa S
IRAD- Department of Pediatrics, Nippon Medical School Hospital, Bunkyo-ku, Tokyo, 
      Japan.
FIR - Ohshima, Miho
IR  - Ohshima M
IRAD- Department of Pediatrics, Sapporo Tokushukai Hospital, Sapporo, Hokkaido, Japan.
FIR - Fukunaga, Hideo
IR  - Fukunaga H
IRAD- Department of Pediatrics, Juntendo University Nerima Hospital, Nerima-ku, Tokyo, 
      Japan.
FIR - Kouzan, Hiroko
IR  - Kouzan H
IRAD- Department of Pediatrics, Takamatsu Red Cross Hospital, Takamatsu, Kagawa, Japan.
FIR - Ichihara, Tomoko
IR  - Ichihara T
IRAD- Department of Pediatrics, Takamatsu Red Cross Hospital, Takamatsu, Kagawa, Japan.
FIR - Hashimoto, Kunio
IR  - Hashimoto K
IRAD- Department of Pediatrics, Nagasaki University Hospital, Nagasaki, Nagasaki, 
      Japan.
FIR - Tokunaga, Hirohide
IR  - Tokunaga H
IRAD- Department of Pediatrics, Nagoya Memorial Hospital, Nagoya, Aichi, Japan.
FIR - Suzuki, Hiroshi
IR  - Suzuki H
IRAD- Department of Pediatrics, Niigata University Medical and Dental Hospital, 
      Niigata, Niigata, Japan.
FIR - Iwashima, Satoru
IR  - Iwashima S
IRAD- Department of Pediatrics, Hamamatsu University Hospital, Hamamatsu, Shizuoka, 
      Japan.
FIR - Hamahira, Kiyoshi
IR  - Hamahira K
IRAD- Department of Pediatrics, Japanese Red Cross Society Himeji Hospital, Himeji, 
      Hyogo, Japan.
FIR - Ishiguchi, Yukiko
IR  - Ishiguchi Y
IRAD- Department of Pediatrics, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, 
      Hiroshima, Japan.
FIR - Kajino, Mayumi
IR  - Kajino M
IRAD- Department of Pediatrics, Asahikawa Kosei General Hospital, Asahikwa, Hokkaido, 
      Japan.
FIR - Kishi, Kanta
IR  - Kishi K
IRAD- Department of Pediatrics, Osaka Medical College Hospital, Takatsuki, Osaka, 
      Japan.
FIR - Nagai, Noriko
IR  - Nagai N
IRAD- Department of Pediatrics, Okazaki City Hospital, Okazaki, Aichi, Japan.
FIR - Ito, Shigeru
IR  - Ito S
IRAD- Department of Pediatrics, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa, 
      Japan.
FIR - Ogino, Hirotaro
IR  - Ogino H
IRAD- Department of Pediatrics, Kansai Medical University Kori Hospital, Hirakata, 
      Osaka, Japan.
FIR - Amaya, Eriko
IR  - Amaya E
IRAD- Department of Pediatrics, Kyoto City Hospital, Kyoto, Kyoto, Japan.
FIR - Doi, Hiraku
IR  - Doi H
IRAD- Department of Pediatrics, Kyoto University Hospital, Kyoto, Kyoto, Japan.
FIR - Waki, Kenji
IR  - Waki K
IRAD- Department of Pediatrics, Kurashiki Central Hospital, Kurashiki, Okayama, Japan.
FIR - Shiraishi, Taisuke
IR  - Shiraishi T
IRAD- Department of Pediatrics, Hata Kenmin Hospital, Sukumo, Kochi, Japan.
FIR - Iwai, Takashi
IR  - Iwai T
IRAD- Department of Pediatrics, Hakodate Goryoukaku Hospital, Hakodate, Hokkaido, 
      Japan.
FIR - Sato, Tetsuji
IR  - Sato T
IRAD- Department of Pediatrics, Hospital of the University of Occupational and 
      Environmental Health, Kitakyushu, Fukuoka, Japan.
FIR - Akimoto, Katsumi
IR  - Akimoto K
IRAD- Department of Pediatrics, Juntendo University Hospital, Bunkyo-ku, Tokyo Japan.
FIR - Soga, Takashi
IR  - Soga T
IRAD- Department of Pediatrics, Showa University Northern Yokohama Hospital, Yokohama, 
      Kanagawa, Japan.
FIR - Naito, Hiroyuki
IR  - Naito H
IRAD- Department of Pediatrics, Chitose City Hospital, Chitose, Hokkaido, Japan.
FIR - Aihara, Makiko
IR  - Aihara M
IRAD- Department of Pediatrics, Saiseikai Kawaguchi General Hospital, Kawaguchi, 
      Saitama, Japan.
FIR - Fukuda, Yutaka
IR  - Fukuda Y
IRAD- Department of Pediatrics, Takeda General Hospital, Kyoto, Kyoto,Japan.
FIR - Imagawa, Kazuo
IR  - Imagawa K
IRAD- Department of Pediatrics, University of Tsukuba Hospital, Tsukuba, Ibaraki, 
      Japan.
FIR - Shiba, Takeshi
IR  - Shiba T
IRAD- Department of Pediatrics, Tenri Hospital, Tenri, Nara, Japan.
FIR - Matsuki, Shigenobu
IR  - Matsuki S
IRAD- Department of Pediatrics, KKR Tohoku Kosai Hospital, Sendai, Miyagi, Japan.
FIR - Miura, Masaru
IR  - Miura M
IRAD- Department of Pediatrics, Tokyo Metropolitan Children's Medical Center, Fuchu, 
      Tokyo,Japan.
FIR - Araki, Tooru
IR  - Araki T
IRAD- Department of Pediatrics, National Hospital Organization Fukuyama Medical Center, 
      Fukuyama, Hiroshima, Japan.
FIR - Furuyama, Hideto
IR  - Furuyama H
IRAD- Department of Pediatrics, Japan Community Health care Organization Hokkaido 
      Hospital, Sapporo, Hokkaido, Japan.
FIR - Naito, Takeshi
IR  - Naito T
IRAD- Department of Pediatrics, Matsushita Memorial Hospital, Moriguchi, Osaka, Japan.
FIR - Miyamoto, Tomoyuki
IR  - Miyamoto T
IRAD- Department of Pediatrics, Yokosuka General Hospital Uwamachi, Yokosuka, 
      Kanagawa,Japan.
EDAT- 2017/12/12 06:00
MHDA- 2019/02/16 06:00
CRDT- 2017/12/12 06:00
PHST- 2017/05/10 00:00 [received]
PHST- 2017/09/10 00:00 [revised]
PHST- 2017/10/12 00:00 [accepted]
PHST- 2017/12/12 06:00 [pubmed]
PHST- 2019/02/16 06:00 [medline]
PHST- 2017/12/12 06:00 [entrez]
AID - S0022-3476(17)31362-8 [pii]
AID - 10.1016/j.jpeds.2017.10.013 [doi]
PST - ppublish
SO  - J Pediatr. 2018 Apr;195:115-120.e3. doi: 10.1016/j.jpeds.2017.10.013. Epub 2017 
      Dec 7.