PMID- 29225207
OWN - NLM
STAT- MEDLINE
DCOM- 20180907
LR  - 20181202
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 65
IP  - 2
DP  - 2018 Feb 26
TI  - Parathyroid carcinoma occurred in two glands in multiple endocrine neoplasia 1: a 
      report on a rare case.
PG  - 245-252
LID - 10.1507/endocrj.EJ17-0409 [doi]
AB  - Primary hyperparathyroidism is the most common hormonal manifestation associated 
      with multiple endocrine neoplasia 1 (MEN1). It is generally caused by parathyroid 
      hyperplasia, and parathyroid carcinoma is rare. Here, we report a case of MEN1 
      with parathyroid carcinoma in two parathyroid glands causing primary 
      hyperparathyroidism. A 40-year-old man with primary hyperparathyroidism due to 
      MEN1 underwent a total parathyroidectomy. His corrected calcium and intact PTH 
      (i-PTH) serum levels were 10.8 mg/dL and 203 pg/mL, respectively. Although three 
      glands were successfully removed, the left upper parathyroid gland could not be 
      detected. Since the right lower parathyroid lesion had invaded into the thyroid, 
      right lobectomy was performed. A portion of the left lower parathyroid tissue was 
      transplanted into his forearm. The histological findings of the left lower and 
      the right upper parathyroid glands were consistent with hyperplasia while that of 
      the right lower parathyroid gland was parathyroid carcinoma. Since the 
      post-surgical i-PTH levels remained high, the intrathyroidal lesion of the left 
      lobe, which was initally diagnosed as an adenomatous nodule, was suspected to 
      contain parathyroid tumor. A fine needle aspiration of the tumor revealed a high 
      concentration of i-PTH. One week after the first surgery, a left thyroid 
      lobectomy was performed. The pathological diagnosis of the tumor was parathyroid 
      carcinoma. After the surgery, calcium and i-PTH levels were normal. Although it 
      is rare, parathyroid carcinoma should be considered as a cause of 
      hyperparathyroidism in MEN1 patients. Since it is difficult to diagnose 
      parathyroid carcinoma before surgery, intraoperative findings are important for 
      the appropriate treatment.
FAU - Omi, Yoko
AU  - Omi Y
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 
      Tokyo, Japan.
FAU - Horiuchi, Kiyomi
AU  - Horiuchi K
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 
      Tokyo, Japan.
FAU - Haniu, Kento
AU  - Haniu K
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 
      Tokyo, Japan.
FAU - Tokura, Momoko
AU  - Tokura M
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 
      Tokyo, Japan.
FAU - Nagai, Erin
AU  - Nagai E
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 
      Tokyo, Japan.
FAU - Isozaki, Osamu
AU  - Isozaki O
AD  - Department of Medicine II, Tokyo Women's Medical University, Tokyo, Japan.
FAU - Nagashima, Yoji
AU  - Nagashima Y
AD  - Department of Surgical Pathology, Tokyo Women's Medical University, Tokyo, Japan.
FAU - Okamoto, Takahiro
AU  - Okamoto T
AD  - Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 
      Tokyo, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20171208
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 0 (Parathyroid Hormone)
SB  - IM
MH  - Adult
MH  - Choristoma/complications/*diagnosis/metabolism
MH  - Humans
MH  - Hyperparathyroidism, Primary/*diagnosis/etiology
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/complications/*diagnosis/pathology
MH  - Neoplasms, Multiple Primary/diagnosis/metabolism/pathology
MH  - Pancreatic Neoplasms/complications/diagnosis/pathology
MH  - Paraneoplastic Endocrine Syndromes/complications/*diagnosis/metabolism
MH  - *Parathyroid Glands
MH  - Parathyroid Hormone/metabolism
MH  - Parathyroid Neoplasms/*diagnosis/pathology
MH  - Thyroid Neoplasms/*diagnosis/metabolism/secondary
OTO - NOTNLM
OT  - Multiple endocrine neoplasia 1
OT  - Parathyroid carcinoma
OT  - Primary hyperparathyroidism
EDAT- 2017/12/12 06:00
MHDA- 2018/09/08 06:00
CRDT- 2017/12/12 06:00
PHST- 2017/12/12 06:00 [pubmed]
PHST- 2018/09/08 06:00 [medline]
PHST- 2017/12/12 06:00 [entrez]
AID - 10.1507/endocrj.EJ17-0409 [doi]
PST - ppublish
SO  - Endocr J. 2018 Feb 26;65(2):245-252. doi: 10.1507/endocrj.EJ17-0409. Epub 2017 
      Dec 8.