PMID- 29225748
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220314
IS  - 2005-6419 (Print)
IS  - 2005-7563 (Electronic)
IS  - 2005-6419 (Linking)
VI  - 70
IP  - 6
DP  - 2017 Dec
TI  - Multiple exposures of sevoflurane during pregnancy induces memory impairment in 
      young female offspring mice.
PG  - 642-647
LID - 10.4097/kjae.2017.70.6.642 [doi]
AB  - BACKGROUND: Earlier studies have reported conflicting results regarding long-term 
      behavioral consequences after anesthesia during the fetal period. Previous 
      studies also suggest several factors that may explain such conflicting data. 
      Thus, we examined the influence of age and sex on long-term behavioral 
      consequences after multiple sevoflurane exposures during the fetal period. 
      METHODS: C57BL/6J pregnant mice received oxygen with or without sevoflurane for 2 
      hours at gestational day (GD) 14-16. Offspring mice were subjected to behavioral 
      assays for general activity (open field test), learning, and memory (fear chamber 
      test) at postnatal day 30-35. RESULTS: Multiple sevoflurane exposures at GD 14-16 
      caused significant changes during the fear chamber test in young female offspring 
      mice. Such changes did not occur in young male offspring mice. However, general 
      activity was not affected in both male and female mice. CONCLUSIONS: Multiple 
      sevoflurane exposures in the second trimester of pregnancy affects learning and 
      memory only in young female mice. Further studies focusing on diverse cognitive 
      functions in an age-, sex-dependent manner may provide valuable insights 
      regarding anesthesia-induced neurotoxicity.
FAU - Chung, Woosuk
AU  - Chung W
AD  - Department of Anesthesiology and Pain Medicine, Chungnam National University 
      Hospital, Daejeon, Korea.
AD  - Department of Anesthesiology and Pain Medicine, Chungnam National University 
      College of Medicine, Daejeon, Korea.
FAU - Yoon, Seunghwan
AU  - Yoon S
AD  - Department of Anesthesiology and Pain Medicine, Chungnam National University 
      Hospital, Daejeon, Korea.
FAU - Shin, Yong Sup
AU  - Shin YS
AUID- ORCID: 0000-0001-5071-734X
AD  - Department of Anesthesiology and Pain Medicine, Chungnam National University 
      Hospital, Daejeon, Korea.
AD  - Department of Anesthesiology and Pain Medicine, Chungnam National University 
      College of Medicine, Daejeon, Korea.
LA  - eng
PT  - Journal Article
DEP - 20171114
PL  - Korea (South)
TA  - Korean J Anesthesiol
JT  - Korean journal of anesthesiology
JID - 101502451
PMC - PMC5716823
OTO - NOTNLM
OT  - Fetus
OT  - Learning
OT  - Memory
OT  - Pregnancy
OT  - Sevoflurane
OT  - Toxicity
EDAT- 2017/12/12 06:00
MHDA- 2017/12/12 06:01
PMCR- 2017/12/01
CRDT- 2017/12/12 06:00
PHST- 2017/07/07 00:00 [received]
PHST- 2017/08/17 00:00 [revised]
PHST- 2017/08/21 00:00 [accepted]
PHST- 2017/12/12 06:00 [entrez]
PHST- 2017/12/12 06:00 [pubmed]
PHST- 2017/12/12 06:01 [medline]
PHST- 2017/12/01 00:00 [pmc-release]
AID - 10.4097/kjae.2017.70.6.642 [doi]
PST - ppublish
SO  - Korean J Anesthesiol. 2017 Dec;70(6):642-647. doi: 10.4097/kjae.2017.70.6.642. 
      Epub 2017 Nov 14.