PMID- 29226117
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 5
DP  - 2017
TI  - Pediatric Anti-N-Methyl-d-Aspartate Receptor Encephalitis: A Review with Pooled 
      Analysis and Critical Care Emphasis.
PG  - 250
LID - 10.3389/fped.2017.00250 [doi]
LID - 250
AB  - PURPOSE: Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is being 
      recognized with increasing frequency among children. Given the paucity of 
      evidence to guide the critical care management of these complex patients, we 
      provide a comprehensive review of the literature with pooled analysis of 
      published case reports and case series. METHODS: We performed a comprehensive 
      literature search using PubMed, Scopus, EMBASE, and Web of Science for relevant 
      published studies. The literature search was conducted using the terms NMDA, 
      anti-NMDA, Anti-N-methyl-d-aspartate, pediatric encephalitis, and anti-NMDAR and 
      included articles published between 2005 and May 1, 2016. RESULTS: Forty-eight 
      references met inclusion criteria accounting for 373 cases. For first-line 
      treatments, 335 (89.8%) received high-dose corticosteroids, 296 received 
      intravenous immunoglobulin (79.3%), and 116 (31%) received therapeutic plasma 
      exchange. In these, 187 children (50.1%) had a full recovery with only minor 
      deficits, 174 patients (46.7%) had partial recovery with major deficits, and 12 
      children died. In addition, 14 patients were reported to require mechanical 
      ventilation. CONCLUSION: Anti-NMDA encephalitis is a formidable disease with 
      great variation in clinical presentation and response to treatment. With early 
      recognition of this second most common cause of pediatric encephalitis, a 
      multidisciplinary approach by physicians may provide earlier access to first- and 
      second-line therapies. Future studies are needed to examine the efficacy of these 
      current therapeutic strategies on long-term morbidity.
FAU - Remy, Kenneth E
AU  - Remy KE
AD  - Division of Pediatric Critical Care Medicine, Department of Pediatrics, 
      University of Maryland School of Medicine, Baltimore, MD, United States.
AD  - Critical Care Medicine Department, Clinical Center, The National Institutes of 
      Health, Bethesda, MD, United States.
AD  - Division of Pediatric Critical Care, Department of Pediatrics, Washington 
      University School of Medicine, St. Louis, MO, United States.
FAU - Custer, Jason W
AU  - Custer JW
AD  - Division of Pediatric Critical Care Medicine, Department of Pediatrics, 
      University of Maryland School of Medicine, Baltimore, MD, United States.
FAU - Cappell, Joshua
AU  - Cappell J
AD  - Divisions of Pediatric Neurology and Critical Care, Departments of Neurology and 
      Pediatrics, Morgan Stanley Children's Hospital, Columbia University College of 
      Physicians and Surgeons, New York, NY, United States.
FAU - Foster, Cortney B
AU  - Foster CB
AD  - Division of Pediatric Critical Care Medicine, Department of Pediatrics, 
      University of Maryland School of Medicine, Baltimore, MD, United States.
FAU - Garber, Nan A
AU  - Garber NA
AD  - Division of Pediatric Critical Care Medicine, Department of Pediatrics, 
      University of Maryland School of Medicine, Baltimore, MD, United States.
FAU - Walker, L Kyle
AU  - Walker LK
AD  - Division of Pediatric Critical Care Medicine, Department of Pediatrics, 
      University of Maryland School of Medicine, Baltimore, MD, United States.
FAU - Simon, Liliana
AU  - Simon L
AD  - Division of Pediatric Critical Care Medicine, Department of Pediatrics, 
      University of Maryland School of Medicine, Baltimore, MD, United States.
FAU - Bagdure, Dayanand
AU  - Bagdure D
AD  - Division of Pediatric Critical Care Medicine, Department of Pediatrics, 
      University of Maryland School of Medicine, Baltimore, MD, United States.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171124
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC5705558
OTO - NOTNLM
OT  - N-methyl-d-aspartate
OT  - N-methyl-d-aspartate receptor
OT  - autoimmune
OT  - critical care
OT  - encephalitis
OT  - paraneoplastic
OT  - pediatrics
EDAT- 2017/12/12 06:00
MHDA- 2017/12/12 06:01
PMCR- 2017/11/24
CRDT- 2017/12/12 06:00
PHST- 2017/04/04 00:00 [received]
PHST- 2017/11/06 00:00 [accepted]
PHST- 2017/12/12 06:00 [entrez]
PHST- 2017/12/12 06:00 [pubmed]
PHST- 2017/12/12 06:01 [medline]
PHST- 2017/11/24 00:00 [pmc-release]
AID - 10.3389/fped.2017.00250 [doi]
PST - epublish
SO  - Front Pediatr. 2017 Nov 24;5:250. doi: 10.3389/fped.2017.00250. eCollection 2017.