PMID- 29226138
OWN - NLM
STAT- MEDLINE
DCOM- 20180717
LR  - 20220409
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2017
DP  - 2017
TI  - Effects of Astaxanthin on Reverse Cholesterol Transport and Atherosclerosis in 
      Mice.
PG  - 4625932
LID - 10.1155/2017/4625932 [doi]
LID - 4625932
AB  - High plasma level of HDL-cholesterol (HDL-C) has been consistently associated 
      with a decreased risk of atherosclerosis (AS); thus, HDL-C is considered to be an 
      antiatherogenic lipoprotein. The development of novel therapies to enhance the 
      atheroprotective properties of HDL may have the possibility of further reducing 
      the residual AS risk. Reverse cholesterol transport (RCT) is believed to be a 
      primary atheroprotective activity of HDL, which has been shown to promote the 
      efflux of excess cholesterol from macrophage-derived foam cells via ATP-binding 
      cassette transporter A1 (ABCA1), ATP-binding cassette transporter G1 (ABCG1), and 
      scavenger receptor class B type I (SR-BI) and then transport it back to the liver 
      for excretion into bile and eventually into the feces. In the current study, we 
      investigated the effects of astaxanthin on RCT and AS progression in mice. The 
      results showed that short- and long-term supplementation of astaxanthin promote 
      RCT in C57BL/6J and ApoE(-/-) mice, respectively. Moreover, astaxanthin can 
      relieve the plaque area of the aortic sinus and aortic cholesterol in mice. These 
      findings suggest that astaxanthin is beneficial for boosting RCT and preventing 
      the development of AS.
FAU - Zou, Tang-Bin
AU  - Zou TB
AD  - Dongguan Key Laboratory of Environmental Medicine, School of Public Health, 
      Guangdong Medical University, Dongguan 523808, China.
FAU - Zhu, Shan-Shan
AU  - Zhu SS
AD  - Dongguan Key Laboratory of Environmental Medicine, School of Public Health, 
      Guangdong Medical University, Dongguan 523808, China.
FAU - Luo, Fei
AU  - Luo F
AD  - Dongguan Key Laboratory of Environmental Medicine, School of Public Health, 
      Guangdong Medical University, Dongguan 523808, China.
FAU - Li, Wei-Qiao
AU  - Li WQ
AD  - Dongguan Key Laboratory of Environmental Medicine, School of Public Health, 
      Guangdong Medical University, Dongguan 523808, China.
FAU - Sun, Xue-Rong
AU  - Sun XR
AUID- ORCID: 0000-0003-2787-4018
AD  - Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong 
      Medical University, Dongguan 523808, China.
FAU - Wu, Hong-Fu
AU  - Wu HF
AUID- ORCID: 0000-0003-4325-1734
AD  - School of Basic Medical Sciences, Guangdong Medical University, Dongguan 523808, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20171101
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Scavenger Receptors, Class B)
RN  - 0 (Xanthophylls)
RN  - 8XPW32PR7I (astaxanthine)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - ATP-Binding Cassette Transporters/metabolism
MH  - Animals
MH  - Apolipoproteins E/metabolism
MH  - Atherosclerosis/*drug therapy/metabolism
MH  - Biological Transport/*drug effects
MH  - Cell Line
MH  - Cholesterol/*metabolism
MH  - Cholesterol, HDL/metabolism
MH  - Foam Cells/drug effects/metabolism
MH  - Macrophages/drug effects/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - RAW 264.7 Cells
MH  - Scavenger Receptors, Class B/metabolism
MH  - Xanthophylls/pharmacology
PMC - PMC5687128
EDAT- 2017/12/12 06:00
MHDA- 2018/07/18 06:00
PMCR- 2017/11/01
CRDT- 2017/12/12 06:00
PHST- 2017/05/08 00:00 [received]
PHST- 2017/09/05 00:00 [revised]
PHST- 2017/09/12 00:00 [accepted]
PHST- 2017/12/12 06:00 [entrez]
PHST- 2017/12/12 06:00 [pubmed]
PHST- 2018/07/18 06:00 [medline]
PHST- 2017/11/01 00:00 [pmc-release]
AID - 10.1155/2017/4625932 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:4625932. doi: 10.1155/2017/4625932. Epub 2017 Nov 1.