PMID- 29226709
OWN - NLM
STAT- MEDLINE
DCOM- 20190528
LR  - 20190528
IS  - 2158-0022 (Electronic)
IS  - 2158-0014 (Linking)
VI  - 8
IP  - 2
DP  - 2018 Mar
TI  - Enhanced Brain Network Activity in Complex Movement Rhythms: A Simultaneous 
      Functional Magnetic Resonance Imaging and Electroencephalography Study.
PG  - 68-81
LID - 10.1089/brain.2017.0547 [doi]
AB  - Generating movement rhythms is known to involve a network of distributed brain 
      regions associated with motor planning, control, execution, and perception of 
      timing for the repertoire of motor actions. What brain areas are bound in the 
      network and how the network activity is modulated by rhythmic complexity have not 
      been completely explored. To contribute to answering these questions, we designed 
      a study in which nine healthy participants performed simple to complex rhythmic 
      finger movement tasks while undergoing simultaneous functional magnetic resonance 
      imaging and electroencephalography (fMRI-EEG) recordings of their brain activity 
      during the tasks and rest. From fMRI blood oxygenation-level-dependent (BOLD) 
      measurements, we found that the complexity of rhythms was associated with brain 
      activations in the primary motor cortex (PMC), supplementary motor area (SMA), 
      and cerebellum (Cb), and with network interactions from these cortical regions to 
      the cerebellum. The spectral analysis of single-trial EEG source waveforms at the 
      cortical regions further showed that there were bidirectional interactions 
      between PMC and SMA, and the complexity of rhythms was associated with power 
      spectra and Granger causality spectra in the beta (13-30 Hz) frequency band, not 
      in the alpha (8-12 Hz) and gamma (30-58 Hz) bands. These results provide us new 
      insights into the mechanisms for movement rhythm complexity.
FAU - Adhikari, Bhim M
AU  - Adhikari BM
AD  - 1 Department of Physics and Astronomy, Georgia State University , Atlanta, 
      Georgia .
AD  - 2 Department of Psychiatry, Maryland Psychiatric Research Center, University of 
      Maryland School of Medicine , Baltimore, Maryland.
FAU - Epstein, Charles M
AU  - Epstein CM
AD  - 3 Department of Neurology, Emory University School of Medicine , Atlanta, Georgia 
      .
FAU - Dhamala, Mukesh
AU  - Dhamala M
AD  - 1 Department of Physics and Astronomy, Georgia State University , Atlanta, 
      Georgia .
AD  - 4 Neuroscience Institute, Georgia State University , Atlanta, Georgia .
AD  - 5 Center for Behavioral Neuroscience, Georgia State University, Atlanta, Georgia 
      .
AD  - 6 Center for Nano-Optics, Georgia State University, Atlanta, Georgia .
AD  - 7 Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, 
      Georgia .
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20180122
PL  - United States
TA  - Brain Connect
JT  - Brain connectivity
JID - 101550313
SB  - IM
MH  - Adult
MH  - Beta Rhythm/physiology
MH  - Brain Waves/*physiology
MH  - Cerebellum/diagnostic imaging/*physiology
MH  - Female
MH  - Fingers/physiology
MH  - Functional Neuroimaging/*methods
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Motor Activity/*physiology
MH  - Motor Cortex/diagnostic imaging/*physiology
MH  - Nerve Net/diagnostic imaging/*physiology
MH  - Time Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Granger causality
OT  - directed connectivity
OT  - information flow
OT  - rhythmic finger tapping
OT  - sensorimotor
EDAT- 2017/12/12 06:00
MHDA- 2019/05/29 06:00
CRDT- 2017/12/12 06:00
PHST- 2017/12/12 06:00 [pubmed]
PHST- 2019/05/29 06:00 [medline]
PHST- 2017/12/12 06:00 [entrez]
AID - 10.1089/brain.2017.0547 [doi]
PST - ppublish
SO  - Brain Connect. 2018 Mar;8(2):68-81. doi: 10.1089/brain.2017.0547. Epub 2018 Jan 
      22.