PMID- 29227253
OWN - NLM
STAT- MEDLINE
DCOM- 20180410
LR  - 20181202
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 272
DP  - 2017 Nov
TI  - [PATHOGENETIC FEATURES OF THE DEVELOPMENT OF OVERACIVE BLADDER IN WOMEN].
PG  - 22-25
AB  - The aim of the research was to study the pathogenetic features of the development 
      of the overactive bladder (OAB) in women. 107 women with OAB and a control group 
      of 29 healthy women were involved into the study. The hormonal status was studied 
      based on the determination of serum concentrations of luteinizing hormone (LH), 
      stimulating hormone (FSH), estradiol and progesterone. The urine levels of 
      interleukin-1beta (IL-1beta), interleukin-4 (IL-4), interleukin-8 (IL-8), tumor 
      necrosis factor alpha (TNF-alpha) and macrophage chemotactic protein-1 (MCP-1) were 
      assessed. Decreased level of estradiol was detected in 26.47% of women of 
      reproductive age. Elevated urine levels of MCP-1 and IL-8 were found in 35.5% of 
      patients. The obtained data testify to the possible pathogenetic role of 
      inflammatory changes in the bladder wall, as well as hypoestrogenism in women of 
      reproductive age in the development of OAB.
FAU - Lesovoy, V
AU  - Lesovoy V
AD  - Kharkov National Medical University Ukraine.
FAU - Kolupayev, S
AU  - Kolupayev S
AD  - Kharkov National Medical University Ukraine.
LA  - rus
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Case-Control Studies
MH  - Chemokine CCL2/urine
MH  - Cytokines/*urine
MH  - Female
MH  - Humans
MH  - Interleukin-8/urine
MH  - Urinary Bladder, Overactive/*physiopathology/urine
EDAT- 2017/12/12 06:00
MHDA- 2018/04/11 06:00
CRDT- 2017/12/12 06:00
PHST- 2017/12/12 06:00 [entrez]
PHST- 2017/12/12 06:00 [pubmed]
PHST- 2018/04/11 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2017 Nov;(272):22-25.