PMID- 29228731
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 58
DP  - 2017 Nov 17
TI  - Impact of anger emotional stress before pregnancy on adult male offspring.
PG  - 98837-98852
LID - 10.18632/oncotarget.22007 [doi]
AB  - Previous studies have reported that maternal chronic stress or depression is 
      linked to an increased risk of affective disorders in progeny. However, the 
      impact of maternal chronic stress before pregnancy on the progeny of animal 
      models is unknown. We investigated the behaviors and the neurobiology of 
      60-day-old male offspring of female rats subjected to 21 days of 
      resident-intruder stress before pregnancy. An anger stressed parental rat model 
      was established using the resident-intruder paradigm and it was evaluated using 
      behavioral tests. Anger stressed maternal rats showed a significant increase in 
      locomotion and aggression but a reduction in sucrose preference. Offspring 
      subjected to pre-gestational anger stress displayed enhanced aggressive 
      behaviors, reduced anxiety, and sucrose preference. Further, offspring subjected 
      to pre-gestational stress showed significant impairments in the recognition index 
      (RI) on the object recognition test and the number of platform crossings in the 
      Morris water maze test. The monoaminergic system was significantly altered in 
      pre-gestationally stressed offspring, and the expression of phosphorylated cyclic 
      adenosine monophosphate response element binding protein (P-CREB), brain-derived 
      neurotrophic factor (BDNF), and serotonin transporter (SERT) levels in 
      pre-gestational stressed offspring were altered in some brain regions. Fluoxetine 
      was used to treat pre-gestational stressed maternal rats and it significantly 
      reduced the changes caused by stress, as evidenced by both behaviors and neural 
      biochemical indexes in the offspring in some but not all cases. These findings 
      suggest that anger stress before pregnancy could induce aggressive behaviors, 
      cognitive deficits, and neurobiological alterations in offspring.
FAU - Wei, Sheng
AU  - Wei S
AD  - Department of Neurosurgery, Qilu Hospital of Shandong University, Brain Science 
      Research Institute, Shandong University, Jinan 250012, China.
AD  - Lab of Traditional Chinese Medicine Classical Theory, Ministry of Education, 
      Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
AD  - Lab of Behavioral Brain Analysis, Shandong University of Traditional Chinese 
      Medicine, Jinan 250355, China.
FAU - Xiao, Xinyang
AU  - Xiao X
AD  - Lab of Behavioral Brain Analysis, Shandong University of Traditional Chinese 
      Medicine, Jinan 250355, China.
FAU - Wang, Jieqiong
AU  - Wang J
AD  - Lab of Traditional Chinese Medicine Classical Theory, Ministry of Education, 
      Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
FAU - Sun, Shiguang
AU  - Sun S
AD  - Second Affiliated Hospital of Shandong University of Traditional Chinese 
      Medicine, Shandong Provincial Hospital of Integrated Medicine, Jinan 250001, 
      China.
FAU - Li, Zifa
AU  - Li Z
AD  - Lab of Behavioral Brain Analysis, Shandong University of Traditional Chinese 
      Medicine, Jinan 250355, China.
FAU - Xu, Kaiyong
AU  - Xu K
AD  - Lab of Behavioral Brain Analysis, Shandong University of Traditional Chinese 
      Medicine, Jinan 250355, China.
FAU - Li, Fang
AU  - Li F
AD  - Fengtai Maternal and Children's Health Hospital of Beijing, Beijing 100069, 
      China.
FAU - Gao, Jie
AU  - Gao J
AD  - Lab of Traditional Chinese Medicine Classical Theory, Ministry of Education, 
      Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
FAU - Zhu, Dehao
AU  - Zhu D
AD  - Lab of Behavioral Brain Analysis, Shandong University of Traditional Chinese 
      Medicine, Jinan 250355, China.
FAU - Qiao, Mingqi
AU  - Qiao M
AD  - Lab of Traditional Chinese Medicine Classical Theory, Ministry of Education, 
      Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
LA  - eng
PT  - Journal Article
DEP - 20171024
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5716771
OTO - NOTNLM
OT  - aggressive behavior test
OT  - anger emotion
OT  - monoamine neurotransmitters
OT  - resident intruder paradigm
OT  - stress before pregnancy
COIS- CONFLICTS OF INTEREST No author has any potential conflicts of interest.
EDAT- 2017/12/13 06:00
MHDA- 2017/12/13 06:01
PMCR- 2017/11/17
CRDT- 2017/12/13 06:00
PHST- 2017/06/21 00:00 [received]
PHST- 2017/10/02 00:00 [accepted]
PHST- 2017/12/13 06:00 [entrez]
PHST- 2017/12/13 06:00 [pubmed]
PHST- 2017/12/13 06:01 [medline]
PHST- 2017/11/17 00:00 [pmc-release]
AID - 22007 [pii]
AID - 10.18632/oncotarget.22007 [doi]
PST - epublish
SO  - Oncotarget. 2017 Oct 24;8(58):98837-98852. doi: 10.18632/oncotarget.22007. 
      eCollection 2017 Nov 17.