PMID- 29230173
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 8
DP  - 2017
TI  - Blueberry Phenolics Reduce Gastrointestinal Infection of Patients with Cerebral 
      Venous Thrombosis by Improving Depressant-Induced Autoimmune Disorder via 
      miR-155-Mediated Brain-Derived Neurotrophic Factor.
PG  - 853
LID - 10.3389/fphar.2017.00853 [doi]
LID - 853
AB  - Cerebral venous thrombosis (CVT) often causes human depression, whereas 
      depression-induced low immunity makes the patients susceptible to 
      gastrointestinal infection. Blueberry possesses antidepressant properties which 
      may improve autoimmunity and reduce gastrointestinal infection. Brain-derived 
      neurotrophic factor (BDNF) performs antidepressant function and can be regulated 
      by miR-155, which may be affected by blueberry. To explore the possible molecular 
      mechanism, blueberry compounds were analyzed by high-performance liquid 
      chromatography. Activity of compounds was tested by using HT22 cells. The present 
      study tested 124 patients with CVT-induced mild-to-moderate depressive symptoms 
      (Center for Epidemiologic Studies-Depression Scale [CES-D] >/=16) and 
      gastrointestinal infection. Patients were randomly assigned to blueberry extract 
      group (BG, received 10 mg blueberry extract daily) and placebo group (PG, 
      received 10 mg placebo daily). After 3 months, depression, gastrointestinal 
      infection and lipid profiles were investigated. Serum miR-155 and BDNF were 
      measured using real-time quantitative polymerase chain reaction and or Western 
      Blot. Blueberry treatment improved depressive symptoms and lipid profiles, and 
      also reduced gastrointestinal infection in the BG group (P < 0.05) but those of 
      the PG group (P = 1). These changes were paralleled by increase in serum levels 
      of BDNF and miR-155 (P < 0.05). HPLC analysis showed that blueberry extracts were 
      the main phenolic acids with 0.18, 0.85, 0.26, 0.72, 0.66, 0.4,1, and 1.92 mg/g 
      of gentisic acid, chlorogenic acid, [2]-epicatechin, p-coumaric acid, benzoic 
      acid, p-anisic acid, and quercetin in blueberry extracts, respectively. Phenolics 
      in blueberry are possible causal agents in improving antidepressant activity and 
      reducing gastrointestinal infection. Administration of blueberry increased BDNF 
      expression and miR-155. Blueberry cannot affect BDNF level when miR-155 is 
      overexpressed or inhibited. Phenolics from blueberry reduced gastrointestinal 
      infection of patients with CVT by improving antidepressant activity via 
      upregulation of miR-155-mediated BDNF.
FAU - Xu, Ning
AU  - Xu N
AD  - Department of Neurosurgery, The First Hospital of Jilin University, Changchun, 
      China.
FAU - Meng, Hao
AU  - Meng H
AD  - Department of Neurosurgery, The First Hospital of Jilin University, Changchun, 
      China.
FAU - Liu, Tianyi
AU  - Liu T
AD  - Department of Neurosurgery, The First Hospital of Jilin University, Changchun, 
      China.
FAU - Feng, Yingli
AU  - Feng Y
AD  - Department of Neurosurgery, The First Hospital of Jilin University, Changchun, 
      China.
FAU - Qi, Yuan
AU  - Qi Y
AD  - Department of Neurosurgery, The First Hospital of Jilin University, Changchun, 
      China.
FAU - Zhang, Donghuan
AU  - Zhang D
AD  - Department of Neurosurgery, The First Hospital of Jilin University, Changchun, 
      China.
FAU - Wang, Honglei
AU  - Wang H
AD  - Department of Neurosurgery, The First Hospital of Jilin University, Changchun, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20171127
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC5712003
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - cerebral venous thrombosis
OT  - depression
OT  - gastrointestinal infection
OT  - miR-155
EDAT- 2017/12/13 06:00
MHDA- 2017/12/13 06:01
PMCR- 2017/11/27
CRDT- 2017/12/13 06:00
PHST- 2017/09/06 00:00 [received]
PHST- 2017/11/07 00:00 [accepted]
PHST- 2017/12/13 06:00 [entrez]
PHST- 2017/12/13 06:00 [pubmed]
PHST- 2017/12/13 06:01 [medline]
PHST- 2017/11/27 00:00 [pmc-release]
AID - 10.3389/fphar.2017.00853 [doi]
PST - epublish
SO  - Front Pharmacol. 2017 Nov 27;8:853. doi: 10.3389/fphar.2017.00853. eCollection 
      2017.