PMID- 29230571
OWN - NLM
STAT- MEDLINE
DCOM- 20180831
LR  - 20181113
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 33
IP  - 6
DP  - 2018 Jun
TI  - Correlation of left ventricular dyssynchrony on gated myocardial perfusion SPECT 
      analysis with extent of late gadolinium enhancement on cardiac magnetic resonance 
      imaging in hypertrophic cardiomyopathy.
PG  - 623-629
LID - 10.1007/s00380-017-1104-2 [doi]
AB  - Myocardial perfusion-single-photon emission computed tomography (MP-SPECT) is 
      used to evaluate microvascular dysfunction and coexisting coronary artery disease 
      in patients with hypertrophic cardiomyopathy (HCM). Phase analysis in gated 
      MP-SPECT can provide additional information on left ventricular (LV) 
      dyssynchrony, while the extent of late gadolinium enhancement (LGE) on cardiac 
      magnetic resonance (CMR) imaging is an important prognostic factor in patients 
      with HCM. We, therefore, sought to investigate the relationship of dyssynchrony 
      by phase analysis on gated MP-SPECT and LGE on CMR imaging in 22 patients with 
      HCM who underwent both stress/rest-gated MP-SPECT and contrast-enhanced CMR 
      imaging. LV dyssynchrony parameters [phase standard deviation (SD) and histogram 
      bandwidth] from gated MP-SPECT were compared with LGE parameters from CMR imaging 
      [L/C contrast and %LGE calculated, respectively, as LGE intensity/LV cavity 
      intensity and (LGE volume/myocardial volume) x 100]. Phase SD and histogram 
      bandwidth showed strong correlation with %LGE (r = 0.73, p < 0.0001 and r = 0.73, 
      p < 0.0001, respectively), although they did not significantly correlate with L/C 
      contrast (r = 0.30, p = 0.17 and r = 0.26, p < 0.25, respectively). The LV 
      dyssynchrony derived from gated MP-SPECT strongly correlated with the extent of 
      LGE on CMR imaging. In conclusion, our investigation suggests that gated MP-SPECT 
      may be useful not only for the assessment of myocardial ischemia but also the 
      extent of myocardial replacement fibrosis.
FAU - Yuki, Hideaki
AU  - Yuki H
AD  - Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1-1-1, 
      Honjo, Chuo-ku, Kumamoto-Shi, Kumamoto, 860-8556, Japan.
FAU - Utsunomiya, Daisuke
AU  - Utsunomiya D
AUID- ORCID: 0000-0002-1723-1724
AD  - Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1-1-1, 
      Honjo, Chuo-ku, Kumamoto-Shi, Kumamoto, 860-8556, Japan. 
      utsunomi@kumamoto-u.ac.jp.
FAU - Shiraishi, Shinya
AU  - Shiraishi S
AD  - Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1-1-1, 
      Honjo, Chuo-ku, Kumamoto-Shi, Kumamoto, 860-8556, Japan.
FAU - Takashio, Seiji
AU  - Takashio S
AD  - Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1, 
      Honjo, Chuo-ku, Kumamoto-Shi, Kumamoto, 860-8556, Japan.
FAU - Sakamoto, Fumi
AU  - Sakamoto F
AD  - Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1-1-1, 
      Honjo, Chuo-ku, Kumamoto-Shi, Kumamoto, 860-8556, Japan.
FAU - Tsuda, Noriko
AU  - Tsuda N
AD  - Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1-1-1, 
      Honjo, Chuo-ku, Kumamoto-Shi, Kumamoto, 860-8556, Japan.
FAU - Oda, Seitaro
AU  - Oda S
AD  - Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1-1-1, 
      Honjo, Chuo-ku, Kumamoto-Shi, Kumamoto, 860-8556, Japan.
FAU - Kidoh, Masafumi
AU  - Kidoh M
AD  - Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1-1-1, 
      Honjo, Chuo-ku, Kumamoto-Shi, Kumamoto, 860-8556, Japan.
FAU - Nakaura, Takeshi
AU  - Nakaura T
AD  - Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1-1-1, 
      Honjo, Chuo-ku, Kumamoto-Shi, Kumamoto, 860-8556, Japan.
FAU - Tsujita, Kenichi
AU  - Tsujita K
AD  - Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1, 
      Honjo, Chuo-ku, Kumamoto-Shi, Kumamoto, 860-8556, Japan.
FAU - Yamashita, Yasuyuki
AU  - Yamashita Y
AD  - Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1-1-1, 
      Honjo, Chuo-ku, Kumamoto-Shi, Kumamoto, 860-8556, Japan.
LA  - eng
PT  - Journal Article
DEP - 20171211
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/diagnosis/*physiopathology
MH  - Contrast Media/pharmacology
MH  - Electrocardiography
MH  - Female
MH  - Gadolinium DTPA/*pharmacology
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Tomography, Emission-Computed, Single-Photon/*methods
MH  - Ventricular Function, Left/*physiology
OTO - NOTNLM
OT  - Dyssynchrony
OT  - Hypertrophic cardiomyopathy
OT  - Magnetic resonance imaging
OT  - Phase analysis
OT  - Single-photon emission computed tomography
EDAT- 2017/12/13 06:00
MHDA- 2018/09/01 06:00
CRDT- 2017/12/13 06:00
PHST- 2017/08/03 00:00 [received]
PHST- 2017/12/08 00:00 [accepted]
PHST- 2017/12/13 06:00 [pubmed]
PHST- 2018/09/01 06:00 [medline]
PHST- 2017/12/13 06:00 [entrez]
AID - 10.1007/s00380-017-1104-2 [pii]
AID - 10.1007/s00380-017-1104-2 [doi]
PST - ppublish
SO  - Heart Vessels. 2018 Jun;33(6):623-629. doi: 10.1007/s00380-017-1104-2. Epub 2017 
      Dec 11.