PMID- 29231458
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 36
IP  - 6
DP  - 2016 Jun 12
TI  - [Action mechanism of electroacupuncture at stomach meridian acupoints for 
      oxidative damage in rats with gastric ulcer].
PG  - 617-621
LID - 10.13703/j.0255-2930.2016.06.017 [doi]
AB  - OBJECTIVE: To observe the effects of electroacupuncture (EA) at stomach meridian 
      acupoints on expression of oxidation damage factors in serum and gastric mucosal 
      cells in rats with gastric ulcer, and to explore the mechanism of EA at stomach 
      meridian acupoints for oxidative damage in rats with gastric ulcer. METHODS: 
      Forty clean-grade SD rats were randomly divided into a normal group, a model 
      group, a stomach meridian group and a gallbladder meridian group, ten rats in 
      each one. Except the normal group, rats in the remaining groups were applied the 
      restraint-cold stress method to establish the model of gastric ulcer. Rats in the 
      normal group and model group received no treatment; rats in the stomach meridian 
      group were treated with EA at "Liangmen" (ST 21) and "Zusanli" (ST 36); rats in 
      the gallbladder meridian group were treated with EA at "Riyue" (GB 24) and 
      "Yanglingquan" (GB 34). The EA was given for 30 min, once a day for 7 days 
      totally. The change of gastric mucosal morphology was observed by routine light 
      microscope; enzyme linked immunosorbent assay was used to detect the expressions 
      of malondialdehyde (MDA), glutathione peroxidase (GSH-px) and tumor necrosis 
      factor-alpha (TNF-alpha), interleukin-2(IL-2), interleukin-6(IL-6) in serum and gastric 
      mucosal cells of rats. RESULTS: After treatment, compared with the model group, 
      the gastric mucosal damage index was decreased in the stomach meridian group and 
      gallbladder meridian group (both P<0.05), the expressions of MDA, TNF-alpha, IL-2 and 
      IL-6 in serum and gastric mucosal cells were significantly decreased in the 
      stomach meridian group (all P<0.01), but the contents of GSH-Px in serum and 
      gastric mucosal cells were increased significantly (both P<0.01). Compared with 
      the gallbladder meridian group, the gastric mucosal damage index as well as the 
      expressions of MDA,TNF-alpha, IL-2 and IL-6 in serum and gastric mucosal cells were 
      significantly decreased in the stomach meridian group rats (P<0.05, P<0.01), and 
      the contents of GSH-px in serum and gastric mucosal cells were increased 
      significantly (both P<0.01). CONCLUSIONS: EA at stomach meridian acupoints is 
      likely to inhibit the expressions of oxidative damage factors to promote the 
      repair of gastric mucosal injury, which indicates the correlation between 
      meridians and zang-fu.
FAU - Yang, Zongbao
AU  - Yang Z
AD  - Department of TCM, Medical College of Xiamen University, Xiamen 361005, Fujian 
      Province, China.
FAU - Wang, Yadong
AU  - Wang Y
AD  - Department of TCM, Medical College of Xiamen University, Xiamen 361005, Fujian 
      Province, China.
FAU - Liu, Qiong
AU  - Liu Q
AD  - College of Acupuncture-Moxibustion and Tuina, Hunan University of CM, Changsha 
      410208.
FAU - Liu, Mi
AU  - Liu M
AD  - College of Acupuncture-Moxibustion and Tuina, Hunan University of CM, Changsha 
      410208.
FAU - Chen, Huijuan
AU  - Chen H
AD  - Department of TCM, Medical College of Xiamen University, Xiamen 361005, Fujian 
      Province, China.
FAU - Chang, Xiaorong
AU  - Chang X
AD  - College of Acupuncture-Moxibustion and Tuina, Hunan University of CM, Changsha 
      410208.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
OTO - NOTNLM
OT  - acupoints in the gallbladder meridian
OT  - acupoints in the stomach meridian
OT  - electroacupuncture (EA)
OT  - oxidative damage factors
OT  - rats
OT  - stomach ulcer
EDAT- 2016/06/12 00:00
MHDA- 2016/06/12 00:01
CRDT- 2017/12/13 06:00
PHST- 2017/12/13 06:00 [entrez]
PHST- 2016/06/12 00:00 [pubmed]
PHST- 2016/06/12 00:01 [medline]
AID - 10.13703/j.0255-2930.2016.06.017 [doi]
PST - ppublish
SO  - Zhongguo Zhen Jiu. 2016 Jun 12;36(6):617-621. doi: 
      10.13703/j.0255-2930.2016.06.017.