PMID- 29232963
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20180827
IS  - 1369-1619 (Electronic)
IS  - 0960-3123 (Linking)
VI  - 28
IP  - 1
DP  - 2018 Feb
TI  - Integrative study of cell damage and cancer risk in gas station attendants.
PG  - 1-7
LID - 10.1080/09603123.2017.1415305 [doi]
AB  - Gas station attendants are potentially exposed to carcinogenic substances. This 
      study aimed to evaluate chronic occupational exposed gas station attendant's 
      according to genetic parameters and its relationship with cancer predisposition. 
      Forty gas station attendants were recruited and paired with 40 control subjects. 
      Thousand cells from each subject were analyzed counting the number of pyknotic 
      (PYC), karyolitic (KYL), karyorrhetic (KHC), condensed chromatin (CC), 
      binucleated (BN), basal cells (BC), Nuclear buds (Nbud), and differentiated cells 
      (DIFF). More 2.000 differentiated cells were analyzed counting micronucleated 
      (MNi) and nuclear buds (NBud). We observed a statistical increase in BC and 
      decrease in DIFF (p < 0.05). PYC, CC, KYL, MN, NBud were statistically increased 
      (p < 0.05). All in all, our data showed elevated DNA damage, chromosomal 
      instability, and cell cycle disturbing in our group of gas station attendants. It 
      is a clear risk for their health in future and could be classified as a cancer 
      predisposition.
FAU - Filho, Antonio P R
AU  - Filho APR
AD  - a Center of Biological Sciences and Health, College of Biological Sciences , 
      State University of West Parana (UNIOESTE) , Cascavel , Brazil.
FAU - Silveira, Maruhen A D
AU  - Silveira MAD
AUID- ORCID: 0000-0002-5711-3562
AD  - a Center of Biological Sciences and Health, College of Biological Sciences , 
      State University of West Parana (UNIOESTE) , Cascavel , Brazil.
FAU - do Nascimento, Camila B
AU  - do Nascimento CB
AD  - a Center of Biological Sciences and Health, College of Biological Sciences , 
      State University of West Parana (UNIOESTE) , Cascavel , Brazil.
FAU - d'Arce, Luciana P G
AU  - d'Arce LPG
AD  - a Center of Biological Sciences and Health, College of Biological Sciences , 
      State University of West Parana (UNIOESTE) , Cascavel , Brazil.
LA  - eng
PT  - Journal Article
DEP - 20171212
PL  - England
TA  - Int J Environ Health Res
JT  - International journal of environmental health research
JID - 9106628
RN  - 0 (Air Pollutants, Occupational)
RN  - 0 (Gasoline)
SB  - IM
MH  - Adult
MH  - Air Pollutants, Occupational/*toxicity
MH  - Cell Count
MH  - Cell Cycle
MH  - *Chromosomal Instability
MH  - *DNA Damage
MH  - Gasoline/*toxicity
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouth Mucosa/*cytology
MH  - Neoplasms/*epidemiology
MH  - Occupational Exposure/adverse effects
MH  - Risk
OTO - NOTNLM
OT  - DNA damage
OT  - cancer risk
OT  - cytogenetic biomarkers
OT  - gas station attendants
OT  - occupational exposure
EDAT- 2017/12/14 06:00
MHDA- 2018/08/28 06:00
CRDT- 2017/12/14 06:00
PHST- 2017/12/14 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2017/12/14 06:00 [entrez]
AID - 10.1080/09603123.2017.1415305 [doi]
PST - ppublish
SO  - Int J Environ Health Res. 2018 Feb;28(1):1-7. doi: 10.1080/09603123.2017.1415305. 
      Epub 2017 Dec 12.