PMID- 29233876
OWN - NLM
STAT- MEDLINE
DCOM- 20180122
LR  - 20220318
IS  - 1744-1358 (Electronic)
IS  - 0071-1365 (Linking)
VI  - 61
IP  - 6
DP  - 2017 Dec 12
TI  - Molecular control of chaperone-mediated autophagy.
PG  - 663-674
LID - 10.1042/EBC20170057 [doi]
AB  - Chaperone-mediated autophagy (CMA) is a selective form of autophagy in which 
      cytosolic proteins bearing a pentapeptide motif biochemically related to the 
      KFERQ sequence, are recognized by the heat shock protein family A member 8 
      (HSPA8) chaperone, delivered to the lysomal membrane, and directly translocated 
      across the lysosomal membrane by a protein complex containing lysosomal 
      associated membrane protein 2a (Lamp2a). Since its discovery over two decades 
      ago, the importance of this pathway in cell proteostasis has been made 
      increasingly apparent. Deregulation of this pathway has been implicated in a 
      variety of diseases and conditions, including lysosomal storage diseases, cancer, 
      neurodegeneration and even aging. Here, we describe the main molecular features 
      of the pathway, its regulation, cross-talk with other degradation pathways and 
      importance in disease.
CI  - (c) 2017 The Author(s). Published by Portland Press Limited on behalf of the 
      Biochemical Society.
FAU - Catarino, Steve
AU  - Catarino S
AD  - Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, 
      University of Coimbra, Coimbra, Portugal.
AD  - CNC.IBILI, University of Coimbra, Coimbra, Portugal.
FAU - Pereira, Paulo
AU  - Pereira P
AD  - Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, 
      University of Coimbra, Coimbra, Portugal.
AD  - CNC.IBILI, University of Coimbra, Coimbra, Portugal.
AD  - Chronic Diseases Research Center (CEDOC), NOVA Medical School, Faculdade de 
      Ciencias Medicas, Universidade NOVA de Lisboa, Lisboa, Portugal.
FAU - Girao, Henrique
AU  - Girao H
AD  - Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, 
      University of Coimbra, Coimbra, Portugal hmgirao@fmed.uc.pt.
AD  - CNC.IBILI, University of Coimbra, Coimbra, Portugal.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20171212
PL  - England
TA  - Essays Biochem
JT  - Essays in biochemistry
JID - 0043306
RN  - 0 (HSC70 Heat-Shock Proteins)
RN  - 0 (Lysosomal-Associated Membrane Protein 2)
RN  - 0 (Molecular Chaperones)
SB  - IM
MH  - Animals
MH  - Autophagy/genetics/*physiology
MH  - HSC70 Heat-Shock Proteins/genetics/metabolism
MH  - Humans
MH  - Lysosomal-Associated Membrane Protein 2/genetics/metabolism
MH  - Lysosomes/metabolism
MH  - Molecular Chaperones/genetics/*metabolism
OTO - NOTNLM
OT  - HSPA8
OT  - Lamp2a
OT  - autophagy
OT  - chaperone-mediated autophagy
EDAT- 2017/12/14 06:00
MHDA- 2018/01/23 06:00
CRDT- 2017/12/14 06:00
PHST- 2017/08/17 00:00 [received]
PHST- 2017/10/23 00:00 [revised]
PHST- 2017/11/01 00:00 [accepted]
PHST- 2017/12/14 06:00 [entrez]
PHST- 2017/12/14 06:00 [pubmed]
PHST- 2018/01/23 06:00 [medline]
AID - EBC20170057 [pii]
AID - 10.1042/EBC20170057 [doi]
PST - epublish
SO  - Essays Biochem. 2017 Dec 12;61(6):663-674. doi: 10.1042/EBC20170057. Print 2017 
      Dec 12.