PMID- 29234149
OWN - NLM
STAT- MEDLINE
DCOM- 20190912
LR  - 20190912
IS  - 1476-5543 (Electronic)
IS  - 0743-8346 (Linking)
VI  - 38
IP  - 3
DP  - 2018 Mar
TI  - Effect of maternal iron deficiency anemia on fetal neural development.
PG  - 233-239
LID - 10.1038/s41372-017-0023-5 [doi]
AB  - OBJECTIVE: Perinatal iron deficiency may have deleterious consequences on fetal 
      neural development. The present study was conducted to determine the effect of 
      maternal iron deficiency anemia (IDA) on fetal hippocampal morphogenesis and 
      production of brain-derived neurotrophic factor (BDNF). STUDY DESIGN: Seventy 
      term, singleton neonates born to mothers with IDA (hemoglobin <110g/L and serum 
      ferritin <12 mug/L) formed the study group. Twenty gestational age-matched 
      neonates born to healthy mothers without IDA (hemoglobin >/=110 g/L and serum 
      ferritin >12 mug/L) served as controls. Maternal and fetal inflammatory 
      conditions, infections and neonates with perinatal asphyxia were excluded. Cord 
      blood BDNF concentrations were estimated by enzyme-linked immunosorbent assay. 
      Volumetric analysis of hippocampus (right, left and combined, corrected for total 
      intracranial volume) was done by cranial magnetic resonance imaging on days 3-5 
      of life. RESULTS: In the study group, 24 mothers had mild (hemoglobin 
      100.0-109.0 g/L), 24 had moderate (hemoglobin 70.0-99.0 g/L), and 22 had severe 
      (hemoglobin <70.0 g/L) anemia. Both hippocampal volumes and serum BDNF 
      concentrations of neonates born to iron-deficient mothers were significantly 
      reduced compared to controls. A progressive decline in hippocampal volumes and 
      BDNF concentrations was observed with increasing severity of maternal anemia. 
      Pearson correlation showed significant correlations among maternal and cord blood 
      hemoglobin, iron indices, hippocampal volumes and BDNF concentrations. 
      CONCLUSIONS: Maternal IDA adversely affects hippocampal morphogenesis and fetal 
      production of BDNF. The degree of affection is proportional to the severity of 
      maternal anemia.
FAU - Basu, Sriparna
AU  - Basu S
AUID- ORCID: 0000-0001-5048-4849
AD  - Division of Neonatology, Department of Pediatrics, Institute of Medical Sciences, 
      Banaras Hindu University, Varanasi, India. drsriparnabasu@rediffmail.com.
FAU - Kumar, Dinesh
AU  - Kumar D
AD  - Division of Neonatology, Department of Pediatrics, Institute of Medical Sciences, 
      Banaras Hindu University, Varanasi, India.
FAU - Anupurba, Shampa
AU  - Anupurba S
AD  - Department of Microbiology, Institute of Science, Banaras Hindu University, 
      Varanasi, India.
FAU - Verma, Ashish
AU  - Verma A
AD  - Department of Radiodiagnosis, Institute of Science, Banaras Hindu University, 
      Varanasi, India.
FAU - Kumar, Ashok
AU  - Kumar A
AD  - Division of Neonatology, Department of Pediatrics, Institute of Medical Sciences, 
      Banaras Hindu University, Varanasi, India.
LA  - eng
PT  - Journal Article
DEP - 20171212
PL  - United States
TA  - J Perinatol
JT  - Journal of perinatology : official journal of the California Perinatal 
      Association
JID - 8501884
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Anemia, Iron-Deficiency/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Fetal Development
MH  - Hippocampus/*pathology
MH  - Humans
MH  - Infant, Newborn
MH  - Iron/blood
MH  - Magnetic Resonance Imaging
MH  - Maternal-Fetal Exchange
MH  - Pregnancy
MH  - Pregnancy Complications, Hematologic/*physiopathology
EDAT- 2017/12/14 06:00
MHDA- 2019/09/13 06:00
CRDT- 2017/12/14 06:00
PHST- 2017/08/08 00:00 [received]
PHST- 2017/11/20 00:00 [accepted]
PHST- 2017/11/03 00:00 [revised]
PHST- 2017/12/14 06:00 [pubmed]
PHST- 2019/09/13 06:00 [medline]
PHST- 2017/12/14 06:00 [entrez]
AID - 10.1038/s41372-017-0023-5 [pii]
AID - 10.1038/s41372-017-0023-5 [doi]
PST - ppublish
SO  - J Perinatol. 2018 Mar;38(3):233-239. doi: 10.1038/s41372-017-0023-5. Epub 2017 
      Dec 12.