PMID- 29234244
OWN - NLM
STAT- MEDLINE
DCOM- 20180821
LR  - 20181113
IS  - 1612-3174 (Electronic)
IS  - 1612-3174 (Linking)
VI  - 15
DP  - 2017
TI  - Genetic alterations in benign prostatic hyperplasia patients.
PG  - Doc16
LID - 10.3205/000257 [doi]
LID - Doc16
AB  - Background: Benign prostate hyperplasia (BPH) is a classical age-related disease 
      of the prostate, present in 20% of men at the age of 40 years with progression to 
      70% by the age of 60 years. BPH is associated with various lower urinary tract 
      symptoms, which affect their day-to-day life. Materials and methods: Our 
      objective was to evaluate the association between HER-2/neu, c-myc, p53, and 
      clinicopathological variables in 45 patients diagnosed with benign prostatic 
      hyperplasia using fluorescence in situ hybridization (FISH). The patients 
      underwent transurethral prostate resection to address their primary urological 
      problem. All patients were evaluated by use of a comprehensive medical history 
      and rectal digital examination. The preoperative evaluation also included serum 
      prostate specific antigen (PSA) measurement and ultrasonographic measurement of 
      prostate volume. Results: The mean (+/- standard deviation) age of the 45 patients 
      was 69.65 +/- 8.97 years. The mean PSA value of the patients was 9.25 +/- 5.12 ng/mL. 
      The mean prostate volume was 65.46 +/- 11.43 mL. Amplification of HER-2/neu was 
      seen in 4/45 (8.9%) cases and amplification of c-myc was seen in 5 of 45 (11.1%) 
      cases; both genes were not associated with adverse clinicopathological variables. 
      Deletion of p53 was seen in 20/45 (44.4%) cases. p53 gene was significantly 
      associated with a severe AUASI (American Urological Association Symptom Index) 
      score. Conclusion: In this study, we discussed important genetic markers in 
      benign prostatic hyperplasia patients which may, in the future, be used as 
      markers for diagnosis and prognosis, as well as targets for therapeutic 
      intervention.
FAU - Mohamed, Hanaa Mahmoud
AU  - Mohamed HM
AD  - Cell Biology and Genetics Division, Zoology Department, Faculty of Science, 
      Beni-Suef University, Beni-Suef, Egypt.
FAU - Aly, Magdy Sayed
AU  - Aly MS
AD  - Cell Biology and Genetics Division, Zoology Department, Faculty of Science, 
      Beni-Suef University, Beni-Suef, Egypt.
FAU - Hussein, Tarek Dardeer
AU  - Hussein TD
AD  - Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20171127
PL  - Germany
TA  - Ger Med Sci
JT  - German medical science : GMS e-journal
JID - 101227686
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 8
MH  - Digital Rectal Examination
MH  - Gene Dosage
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lower Urinary Tract Symptoms/etiology
MH  - Male
MH  - Middle Aged
MH  - Organ Size
MH  - Prostate/diagnostic imaging/*pathology
MH  - Prostate-Specific Antigen/blood
MH  - Prostatic Hyperplasia/blood/diagnostic imaging/*genetics/surgery
MH  - Proto-Oncogene Proteins c-myc/*genetics
MH  - Receptor, ErbB-2/*genetics
MH  - Severity of Illness Index
MH  - Tumor Suppressor Protein p53/*genetics
MH  - Ultrasonography
PMC - PMC5705825
OTO - NOTNLM
OT  - BPH
OT  - FISH
OT  - amplification
OT  - benign prostatic hyperplasia
OT  - deletion
OT  - fluorescence in situ hybridization
OT  - genes
COIS- The authors declare that they have no competing interests.
EDAT- 2017/12/14 06:00
MHDA- 2018/08/22 06:00
PMCR- 2017/11/27
CRDT- 2017/12/14 06:00
PHST- 2017/08/21 00:00 [received]
PHST- 2017/10/20 00:00 [revised]
PHST- 2017/12/14 06:00 [entrez]
PHST- 2017/12/14 06:00 [pubmed]
PHST- 2018/08/22 06:00 [medline]
PHST- 2017/11/27 00:00 [pmc-release]
AID - 000257 [pii]
AID - Doc16 [pii]
AID - 10.3205/000257 [doi]
PST - epublish
SO  - Ger Med Sci. 2017 Nov 27;15:Doc16. doi: 10.3205/000257. eCollection 2017.