PMID- 29234369
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2017
DP  - 2017
TI  - Bufei Yishen Granules Combined with Acupoint Sticking Therapy Suppress 
      Inflammation in Chronic Obstructive Pulmonary Disease Rats: Via JNK/p38 Signaling 
      Pathway.
PG  - 1768243
LID - 10.1155/2017/1768243 [doi]
LID - 1768243
AB  - The present study was initiated to explore the mechanism of the effects of Bufei 
      Yishen granules combined with acupoint sticking therapy (Shu-Fei Tie) on 
      inflammation regulated by c-Jun N-terminal kinase (JNK) and p38 MAPK signaling in 
      COPD rats. Seventy-two rats were divided into healthy control (Control), Model, 
      Bufei Yishen (BY), acupoint sticking (AS), Bufei Yishen + acupoint sticking (BY + 
      AS), and aminophylline (APL) groups (n = 12 each). COPD rats were exposed to 
      cigarette smoke and bacteria and were given the various treatments from weeks 9 
      through 20; all animals were sacrificed at the end of week 20. MCP-1, IL-2, IL-6, 
      and IL-10 concentrations in BALF and lung tissue as well as JNK and p38 mRNA and 
      protein levels in lung were measured. The results showed that all the four 
      treatment protocols (BY, AS, BY + AS, and APL) markedly reduced the 
      concentrations of IL-2, IL-6, and MCP-1 and levels of JNK and p38 MAPK mRNA, and 
      the effects of Bufei Yishen granules combined with acupoint sticking therapy were 
      better than acupoint sticking therapy only and aminophylline. In conclusion, the 
      favorable effect of Bufei Yishen granules combined with Shu-Fei Tie may be due to 
      decreased inflammation through regulation of the JNK/p38 signaling pathways.
FAU - Tian, Yange
AU  - Tian Y
AUID- ORCID: 0000-0002-5849-4504
AD  - Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450046, China.
AD  - Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & 
      Chinese Medicine Development of Henan Province, Henan University of Chinese 
      Medicine, Zhengzhou, Henan 450046, China.
FAU - Li, Ya
AU  - Li Y
AD  - Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450046, China.
AD  - Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & 
      Chinese Medicine Development of Henan Province, Henan University of Chinese 
      Medicine, Zhengzhou, Henan 450046, China.
AD  - Central Laboratory and Respiratory Pharmacological Laboratory of Chinese 
      Medicine, The First Affiliated Hospital, Henan University of Chinese Medicine, 
      Zhengzhou, Henan 450008, China.
FAU - Li, Jiansheng
AU  - Li J
AUID- ORCID: 0000-0002-2714-9353
AD  - Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450046, China.
AD  - Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & 
      Chinese Medicine Development of Henan Province, Henan University of Chinese 
      Medicine, Zhengzhou, Henan 450046, China.
AD  - Institute of Respiratory Diseases, The First Affiliated Hospital, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450008, China.
FAU - Feng, Suxiang
AU  - Feng S
AD  - Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450046, China.
AD  - Institute of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan 
      450046, China.
FAU - Li, Suyun
AU  - Li S
AD  - Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450046, China.
AD  - Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & 
      Chinese Medicine Development of Henan Province, Henan University of Chinese 
      Medicine, Zhengzhou, Henan 450046, China.
AD  - Institute of Respiratory Diseases, The First Affiliated Hospital, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450008, China.
FAU - Mao, Jing
AU  - Mao J
AD  - Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450046, China.
AD  - Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & 
      Chinese Medicine Development of Henan Province, Henan University of Chinese 
      Medicine, Zhengzhou, Henan 450046, China.
FAU - Xie, Yang
AU  - Xie Y
AD  - Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450046, China.
AD  - Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & 
      Chinese Medicine Development of Henan Province, Henan University of Chinese 
      Medicine, Zhengzhou, Henan 450046, China.
AD  - Institute of Respiratory Diseases, The First Affiliated Hospital, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450008, China.
FAU - Liu, Xuefang
AU  - Liu X
AD  - Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450046, China.
AD  - Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & 
      Chinese Medicine Development of Henan Province, Henan University of Chinese 
      Medicine, Zhengzhou, Henan 450046, China.
FAU - Dong, Haoran
AU  - Dong H
AD  - Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450046, China.
AD  - Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & 
      Chinese Medicine Development of Henan Province, Henan University of Chinese 
      Medicine, Zhengzhou, Henan 450046, China.
FAU - Zheng, Wanchun
AU  - Zheng W
AD  - Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450046, China.
AD  - Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & 
      Chinese Medicine Development of Henan Province, Henan University of Chinese 
      Medicine, Zhengzhou, Henan 450046, China.
FAU - Wang, Minghang
AU  - Wang M
AD  - Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450046, China.
AD  - Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & 
      Chinese Medicine Development of Henan Province, Henan University of Chinese 
      Medicine, Zhengzhou, Henan 450046, China.
AD  - Institute of Respiratory Diseases, The First Affiliated Hospital, Henan 
      University of Chinese Medicine, Zhengzhou, Henan 450008, China.
LA  - eng
PT  - Journal Article
DEP - 20171030
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5682917
EDAT- 2017/12/14 06:00
MHDA- 2017/12/14 06:01
PMCR- 2017/10/30
CRDT- 2017/12/14 06:00
PHST- 2017/06/02 00:00 [received]
PHST- 2017/09/16 00:00 [revised]
PHST- 2017/10/02 00:00 [accepted]
PHST- 2017/12/14 06:00 [entrez]
PHST- 2017/12/14 06:00 [pubmed]
PHST- 2017/12/14 06:01 [medline]
PHST- 2017/10/30 00:00 [pmc-release]
AID - 10.1155/2017/1768243 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2017;2017:1768243. doi: 10.1155/2017/1768243. 
      Epub 2017 Oct 30.