PMID- 29235396
OWN - NLM
STAT- MEDLINE
DCOM- 20180710
LR  - 20221207
IS  - 1502-4725 (Electronic)
IS  - 0803-9488 (Linking)
VI  - 72
IP  - 3
DP  - 2018 Apr
TI  - Brain-derived neurotrophic factor (BDNF) serum level in women with first-episode 
      depression, correlation with clinical and metabolic parameters.
PG  - 191-196
LID - 10.1080/08039488.2017.1415373 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) influences neuron 
      differentiation during development, as well as the synaptic plasticity and neuron 
      survival in adulthood. BDNF has been implicated in the pathogenesis of 
      psychiatric disorders and its serum level is a potential biomarker for 
      depression. The aim of this study was to examine serum levels of BDNF in 
      first-episode depression and its correlation with clinical and metabolic 
      parameters. MATERIALS AND METHODS: The study was performed on a group of 60 
      women: 30 diagnosed with a first-episode of depression and 30 healthy controls. 
      17-Item Hamilton Depression Rating Scale (HDRS-17) was used to assess the 
      severity of depression. Patients were randomly chosen for treatment with 
      sertraline or venlafaxine. BDNF serum levels and metabolic parameters: fasting 
      serum glucose, cholesterol, triglyceride (TG), high-density lipoprotein (HDL-C), 
      low-density lipoprotein (LDL-C) were measured at baseline and week 8 of 
      treatment. RESULTS: There were no differences between BDNF level in depressed 
      patients compared with the healthy controls. Lack of differences in medication 
      effect of sertraline or venlafaxine on HDRS-17 scores during 8 weeks of treatment 
      was observed. Correlation of BDNF at baseline and fasting serum glucose at 
      baseline and week 8 was detected. CONCLUSIONS: Correlations of BDNF serum levels 
      with metabolic parameters were observed.
FAU - Skibinska, Maria
AU  - Skibinska M
AUID- ORCID: 0000-0002-5634-1061
AD  - a Psychiatric Genetics Unit, Department of Psychiatry , Poznan University of 
      Medical Sciences , Poznan , Poland.
FAU - Kapelski, Pawel
AU  - Kapelski P
AD  - a Psychiatric Genetics Unit, Department of Psychiatry , Poznan University of 
      Medical Sciences , Poznan , Poland.
FAU - Rajewska-Rager, Aleksandra
AU  - Rajewska-Rager A
AD  - b Department of Adult Psychiatry , Poznan University of Medical Sciences , Poland 
      Poznan.
FAU - Pawlak, Joanna
AU  - Pawlak J
AD  - a Psychiatric Genetics Unit, Department of Psychiatry , Poznan University of 
      Medical Sciences , Poznan , Poland.
FAU - Szczepankiewicz, Aleksandra
AU  - Szczepankiewicz A
AD  - a Psychiatric Genetics Unit, Department of Psychiatry , Poznan University of 
      Medical Sciences , Poznan , Poland.
AD  - c Laboratory of Molecular and Cell Biology , Poznan University of Medical 
      Sciences , Poznan , Poland.
FAU - Narozna, Beata
AU  - Narozna B
AD  - c Laboratory of Molecular and Cell Biology , Poznan University of Medical 
      Sciences , Poznan , Poland.
FAU - Twarowska-Hauser, Joanna
AU  - Twarowska-Hauser J
AD  - a Psychiatric Genetics Unit, Department of Psychiatry , Poznan University of 
      Medical Sciences , Poznan , Poland.
FAU - Dmitrzak-Weglarz, Monika
AU  - Dmitrzak-Weglarz M
AD  - a Psychiatric Genetics Unit, Department of Psychiatry , Poznan University of 
      Medical Sciences , Poznan , Poland.
LA  - eng
PT  - Journal Article
DEP - 20171213
PL  - England
TA  - Nord J Psychiatry
JT  - Nordic journal of psychiatry
JID - 100927567
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 0 (Serotonin and Noradrenaline Reuptake Inhibitors)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 7D7RX5A8MO (Venlafaxine Hydrochloride)
RN  - QUC7NX6WMB (Sertraline)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cross-Sectional Studies
MH  - Depression/*blood/*diagnosis/drug therapy
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Selective Serotonin Reuptake Inhibitors/therapeutic use
MH  - Serotonin and Noradrenaline Reuptake Inhibitors/therapeutic use
MH  - Sertraline/therapeutic use
MH  - Venlafaxine Hydrochloride/therapeutic use
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - enzyme-linked immunosorbent assay
OT  - first-episode depression
OT  - metabolic parameters
EDAT- 2017/12/14 06:00
MHDA- 2018/07/11 06:00
CRDT- 2017/12/14 06:00
PHST- 2017/12/14 06:00 [pubmed]
PHST- 2018/07/11 06:00 [medline]
PHST- 2017/12/14 06:00 [entrez]
AID - 10.1080/08039488.2017.1415373 [doi]
PST - ppublish
SO  - Nord J Psychiatry. 2018 Apr;72(3):191-196. doi: 10.1080/08039488.2017.1415373. 
      Epub 2017 Dec 13.