PMID- 29237268
OWN - NLM
STAT- MEDLINE
DCOM- 20180205
LR  - 20180205
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 66
IP  - 1
DP  - 2018 Jan 10
TI  - Sesquiterpenoids from the Root of Panax ginseng Attenuates 
      Lipopolysaccharide-Induced Depressive-Like Behavior through the Brain-Derived 
      Neurotrophic Factor/Tropomyosin-Related Kinase B and Sirtuin Type 1/Nuclear 
      Factor-kappaB Signaling Pathways.
PG  - 265-271
LID - 10.1021/acs.jafc.7b04835 [doi]
AB  - The previous study indicated sesquiterpenoids from the root of Panax ginseng 
      (SPG) exhibited a significant antidepressant-like effect, which might be mediated 
      by the modification of the dopaminergic, GABAergic, and glutamatergic systems. 
      This study was to investigate antidepressant effects and mechanisms on the 
      lipopolysaccharide (LPS)-induced depression-like behavior of SPG. In the tail 
      suspension test (TST) and forced swimming test (FST), SPG (0.25 and 1 mg/kg, 
      i.g.) and fluoxetine (20 mg/kg, i.p.) effectively reduced the immobility time. 
      SPG treatment significantly reduced serum levels of IL-6 and TNF-alpha and increased 
      suppressed superoxide dismutase (SOD) activity in the hippocampus. In addition, 
      SPG effectively upregulated the brain-derived neurotrophic factor (BDNF), 
      tropomyosin-related kinase B (TrkB), and sirtuin type 1 (Sirt 1) expression in 
      the hippocampus and downregulated the inhibitor of kappaB-alpha (IkappaB-alpha) and nuclear 
      factor-kappaB (NF-kappaB) phosphorylation. These results suggested that SPG exhibited an 
      antidepressant-like effect through the BDNF/TrkB and Sirt 1/NF-kappaB signaling 
      pathways.
FAU - Wang, Weidong
AU  - Wang W
AUID- ORCID: 0000-0003-4628-3555
AD  - College of Chinese Medicinal Materials, Jilin Agricultural University , 
      Changchun, Jilin 130118, People's Republic of China.
FAU - Liu, Xiaofeng
AU  - Liu X
AD  - Ningxia People's Hospital , Yinchuan, Ningxia 750021, People's Republic of China.
FAU - Liu, Jinping
AU  - Liu J
AD  - Jilin University , Changchun, Jilin 130021, People's Republic of China.
FAU - Cai, Enbo
AU  - Cai E
AD  - College of Chinese Medicinal Materials, Jilin Agricultural University , 
      Changchun, Jilin 130118, People's Republic of China.
FAU - Zhao, Yan
AU  - Zhao Y
AD  - College of Chinese Medicinal Materials, Jilin Agricultural University , 
      Changchun, Jilin 130118, People's Republic of China.
FAU - Li, Haijun
AU  - Li H
AD  - Jilin University , Changchun, Jilin 130021, People's Republic of China.
FAU - Zhang, Lianxue
AU  - Zhang L
AD  - College of Chinese Medicinal Materials, Jilin Agricultural University , 
      Changchun, Jilin 130118, People's Republic of China.
FAU - Li, Pingya
AU  - Li P
AD  - Jilin University , Changchun, Jilin 130021, People's Republic of China.
FAU - Gao, Yugang
AU  - Gao Y
AD  - College of Chinese Medicinal Materials, Jilin Agricultural University , 
      Changchun, Jilin 130118, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20171221
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Sesquiterpenes)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (tropomyosin-related kinase-B, human)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*administration & dosage/chemistry
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Depressive Disorder/chemically induced/*drug therapy/psychology
MH  - Drugs, Chinese Herbal/*administration & dosage/chemistry
MH  - Humans
MH  - Lipopolysaccharides/adverse effects
MH  - Male
MH  - Membrane Glycoproteins/genetics/*metabolism
MH  - Mice, Inbred ICR
MH  - Molecular Structure
MH  - Panax/*chemistry
MH  - Plant Roots/chemistry
MH  - Receptor, trkB/genetics/*metabolism
MH  - Sesquiterpenes/*administration & dosage/chemistry
OTO - NOTNLM
OT  - LPS-induced depression
OT  - inflammation
OT  - neurotrophy
OT  - sesquiterpenoids
EDAT- 2017/12/15 06:00
MHDA- 2018/02/06 06:00
CRDT- 2017/12/15 06:00
PHST- 2017/12/15 06:00 [pubmed]
PHST- 2018/02/06 06:00 [medline]
PHST- 2017/12/15 06:00 [entrez]
AID - 10.1021/acs.jafc.7b04835 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2018 Jan 10;66(1):265-271. doi: 10.1021/acs.jafc.7b04835. Epub 
      2017 Dec 21.