PMID- 29237375
OWN - NLM
STAT- MEDLINE
DCOM- 20191114
LR  - 20191114
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 24
IP  - 13
DP  - 2018
TI  - Adhesive Drug Delivery Systems Based on Polyelectrolyte Complex Nanoparticles 
      (PEC NP) for Bone Healing.
PG  - 1341-1348
LID - 10.2174/1381612824666171213095523 [doi]
AB  - BACKGROUND: In this contribution an overview is given on own work concerning drug 
      loaded Polyelectrolyte Complex (PEC) Nanoparticles (NP) used to functionalize 
      Bone Substitute Materials (BSM) for the therapy of bone defects associated with 
      systemic bone diseases. In this context, drug loaded PEC NP have certain 
      advantages, which are exemplarily summarized herein. METHODS: Concerning 
      preparative methods PEC NP were fabricated by controlled mixing of polycation and 
      polyanion solutions and integration of charged drugs during and after mixing. 
      Control was taken on the stoichiometric ratio related to cationic and anionic 
      repeating units, which was chosen close to zero for the final applied PEC NP. 
      Concerning analytical methods a couple of physical-chemical methods were applied 
      like colloid titration, Dynamic Light Scattering (DLS), Scanning Force Microscopy 
      (SFM), Fourier Transform infrared (FTIR) spectroscopy, Ultraviolet-Visible 
      (UV-VIS) and Circular Dichroism (CD) spectroscopy to characterize colloid 
      stability, adhesiveness, drug loading and release of PEC NP. Moreover, standard 
      biochemical and microbiological assays were applied. CONCLUSION: Drug loaded PEC 
      NP consist of oppositely charged biorelated Polyelectrolytes (PEL) like ionic 
      polysaccharides or ionic polypeptides and also synthetic PEL, which are mixed and 
      processed in aqueous media. At first, freshly prepared drug/PEC NP exhibit time 
      dependent colloidal stability in the range of weeks and months, which enables and 
      simplifies storage, transport and application in the medical field. Secondly, 
      after deposition and drying of drug/PEC NP a local wet adhesive PEC matrix at the 
      BSM remains in contact to relevant aqueous media (e.g. buffer, cell culture 
      medium), which minimizes asepsis, systemic toxicity, immune or inflammatory 
      reaction. Thirdly, cell compatible PEC NP coatings were identified, which showed 
      only minimal effects on various relevant bone related cells due to biorelateness, 
      complexation, local confinement and low surface area. Fourthly, PEC NP elute 
      drugs for bone healing like bisphosphonates, antibiotics and growth factors (e.g. 
      bone morphogenetic proteins) in delayed and sustained manner. Moreover, the onset 
      of elution could be triggered by thermoresponsive PEL via temperature increase 
      giving clinicians a tool into hand allowing spatiotemporal drug release on 
      demand. Finally, drug/PEC NP could be integrated into commercial or still 
      developed allotropic stabilizing or defect filling BSM systems.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Muller, Martin
AU  - Muller M
AD  - Leibniz-Institut fur Polymerforschung Dresden e.V., Abteilung Polyelektrolyte und 
      Dispersionen, Hohe Strasse 6, D-01069 Dresden, Germany.
AD  - Technische Universitat Dresden, Fachrichtung fur Chemie und Lebensmittelchemie, 
      D-01062 Dresden, Germany.
FAU - Vehlow, David
AU  - Vehlow D
AD  - Leibniz-Institut fur Polymerforschung Dresden e.V., Abteilung Polyelektrolyte und 
      Dispersionen, Hohe Strasse 6, D-01069 Dresden, Germany.
AD  - Technische Universitat Dresden, Fachrichtung fur Chemie und Lebensmittelchemie, 
      D-01062 Dresden, Germany.
FAU - Torger, Bernhard
AU  - Torger B
AD  - Leibniz-Institut fur Polymerforschung Dresden e.V., Abteilung Polyelektrolyte und 
      Dispersionen, Hohe Strasse 6, D-01069 Dresden, Germany.
AD  - Technische Universitat Dresden, Institut fur Pflanzen- und Holzchemie, D-01737 
      Tharandt, Germany.
FAU - Urban, Birgit
AU  - Urban B
AD  - Leibniz-Institut fur Polymerforschung Dresden e.V., Abteilung Polyelektrolyte und 
      Dispersionen, Hohe Strasse 6, D-01069 Dresden, Germany.
FAU - Woltmann, Beatrice
AU  - Woltmann B
AD  - Technische Universitat Dresden, Medizinische Fakultat Carl Gustav Carus, Institut 
      fur Physiologische Chemie, 01307 Dresden, Germany.
FAU - Hempel, Ute
AU  - Hempel U
AD  - Technische Universitat Dresden, Medizinische Fakultat Carl Gustav Carus, Institut 
      fur Physiologische Chemie, 01307 Dresden, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
RN  - 0 (Adhesives)
RN  - 0 (Drug Carriers)
RN  - 0 (Polyelectrolytes)
SB  - IM
MH  - *Adhesives
MH  - Animals
MH  - Bone Diseases/*drug therapy
MH  - Drug Carriers/*chemistry
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Nanoparticles/*chemistry
MH  - Polyelectrolytes/*chemistry
OTO - NOTNLM
OT  - FTIR spectroscopy
OT  - Osteoporosis
OT  - bisphosphonate
OT  - bone healing
OT  - bone morphogenetic protein 2
OT  - bone substitute materials
OT  - drug delivery system
OT  - nanoparticle
OT  - polyelectrolyte complex
OT  - polysaccharide.
EDAT- 2017/12/15 06:00
MHDA- 2019/11/15 06:00
CRDT- 2017/12/15 06:00
PHST- 2017/07/16 00:00 [received]
PHST- 2017/11/22 00:00 [revised]
PHST- 2017/12/04 00:00 [accepted]
PHST- 2017/12/15 06:00 [pubmed]
PHST- 2019/11/15 06:00 [medline]
PHST- 2017/12/15 06:00 [entrez]
AID - CPD-EPUB-87368 [pii]
AID - 10.2174/1381612824666171213095523 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2018;24(13):1341-1348. doi: 10.2174/1381612824666171213095523.