PMID- 29237712
OWN - NLM
STAT- MEDLINE
DCOM- 20190301
LR  - 20221207
IS  - 1479-6821 (Electronic)
IS  - 1351-0088 (Linking)
VI  - 25
IP  - 3
DP  - 2018 Mar
TI  - Receptor activities of persistent pollutant serum mixtures and breast cancer 
      risk.
PG  - 201-215
LID - 10.1530/ERC-17-0366 [doi]
AB  - Studies on associations between persistent organic pollutants (POPs) and breast 
      cancer risk are inconclusive. The majority of studies have evaluated the effect 
      of single compounds, without considering multiple exposures to and interactions 
      between different POPs. The present study aimed at evaluating breast cancer risk 
      related to combined effects of serum POP mixtures on cellular receptor functions. 
      Data on breast cancer cases (n = 77) and controls (n = 84) were collected among 
      Greenlandic Inuit women. Serum mixtures of lipophilic POPs (lipPOPs), 
      perfluoroalkyl acids (PFAAs) and dioxin-like POPs were extracted. The effect of 
      the mixture extracts on the estrogen receptor (ER), androgen receptor (AR) and 
      aryl hydrocarbon receptor (AhR) was determined using cell culture reporter gene 
      assays. The serum mixtures were analyzed alone and upon co-exposure with natural 
      receptor ligands to determine agonistic and antagonistic/competitive activity. We 
      found that the frequency of lipPOP mixtures eliciting no, decreasing, or 
      agonizing xenoandrogenic effect differed by breast cancer status. Using lipPOP 
      mixtures with no effect on AR as reference, the mixtures with decreasing effects 
      reduced breast cancer risk (OR: 0.30 (0.12; 0.76)). The AhR-toxic equivalent of 
      serum mixtures was significantly lower in cases than in controls, and a reduced 
      breast cancer risk was found when comparing the third tertile to the first (OR: 
      0.34 (0.14; 0.83)). We found no association between the xenoestrogenic activities 
      of lipPOPs or PFAAs and breast cancer risk. Serum lipPOP mixtures are hormone 
      disruptive and may influence breast cancer risk, whereas PFAAs seem to influence 
      breast cancer risk through other pathways.
CI  - (c) 2018 Society for Endocrinology.
FAU - Wielsoe, Maria
AU  - Wielsoe M
AD  - Centre for Arctic Health & Molecular EpidemiologyDepartment of Public Health, 
      Aarhus University, Aarhus, Denmark.
FAU - Bjerregaard-Olesen, Christian
AU  - Bjerregaard-Olesen C
AD  - Centre for Arctic Health & Molecular EpidemiologyDepartment of Public Health, 
      Aarhus University, Aarhus, Denmark.
FAU - Kern, Peder
AU  - Kern P
AD  - Department of Gynecology and ObstetricsDronning Ingrid's Hospital, Nuuk, 
      Greenland.
FAU - Bonefeld-Jorgensen, Eva Cecilie
AU  - Bonefeld-Jorgensen EC
AD  - Centre for Arctic Health & Molecular EpidemiologyDepartment of Public Health, 
      Aarhus University, Aarhus, Denmark ebj@ph.au.dk.
AD  - Institute for Nursing and Health ScienceUniversity of Greenland, Nuuk, Greenland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171213
PL  - England
TA  - Endocr Relat Cancer
JT  - Endocrine-related cancer
JID - 9436481
RN  - 0 (AR protein, human)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Androgen)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Animals
MH  - Breast Neoplasms/*blood
MH  - Cell Line
MH  - Cricetulus
MH  - Endocrine Disruptors/*blood
MH  - Environmental Pollutants/*blood
MH  - Estrogens/*blood
MH  - Female
MH  - Greenland
MH  - Humans
MH  - Inuit
MH  - Receptors, Androgen/metabolism
MH  - Receptors, Aryl Hydrocarbon/metabolism
MH  - Receptors, Estrogen/metabolism
MH  - Risk
OTO - NOTNLM
OT  - arctic
OT  - organochlorine pesticides (OCPs)
OT  - perfluoroalkyl acid (PFAA)
OT  - polychlorinated biphenyl (PCB)
OT  - xenohormone and dioxin-like receptor activity
EDAT- 2017/12/15 06:00
MHDA- 2019/03/02 06:00
CRDT- 2017/12/15 06:00
PHST- 2017/12/05 00:00 [received]
PHST- 2017/12/13 00:00 [accepted]
PHST- 2017/12/15 06:00 [pubmed]
PHST- 2019/03/02 06:00 [medline]
PHST- 2017/12/15 06:00 [entrez]
AID - ERC-17-0366 [pii]
AID - 10.1530/ERC-17-0366 [doi]
PST - ppublish
SO  - Endocr Relat Cancer. 2018 Mar;25(3):201-215. doi: 10.1530/ERC-17-0366. Epub 2017 
      Dec 13.