PMID- 29238301
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 8
DP  - 2017
TI  - Association of HLA-A and HLA-B Alleles with Lamotrigine-Induced Cutaneous Adverse 
      Drug Reactions in the Thai Population.
PG  - 879
LID - 10.3389/fphar.2017.00879 [doi]
LID - 879
AB  - Background: Lamotrigine (LTG) is commonly used for treatment of epilepsy and 
      bipolar disorder. It is one of the common cause of cutaneous adverse drug 
      reactions (CADR). Clinical symptoms of LTG-induced CADR range from maculopapular 
      exanthema (MPE) to severe cutaneous adverse reactions (SCAR). This study aimed to 
      determine the association of the LTG-induced CADR with human leukocyte antigen 
      (HLA) alleles in Thai patients. Methods: Fifteen patients with LTG-induced CADR 
      [10 MPE; 4 Stevens-Johnson syndrome; and 1 drug reaction with eosinophilia and 
      systemic symptoms] and 50 LTG-tolerant controls were included in the study. HLA-A 
      and HLA-B genotyping was performed using polymerase chain 
      reaction-sequence-specific oligonucleotides probes. Results: The proportion of 
      HLA-A( *)02:07 and HLA-B( *)15:02 allele carriers were significantly higher in the 
      LTG-induced CADR group than in the tolerant controls [odds ratio (OR): 7.83; 95% 
      confidence interval (CI): 1.60-38.25; P = 0.013, and OR: 4.89; 95% CI: 
      1.28-18.67; P = 0.014]. In addition, subjects with HLA-A( *)33:03, HLA-B( *)15:02, 
      and HLA-B( *)44:03 were significantly higher in the LTG-induced MPE group than in 
      the tolerant controls (OR: 8.27; 95% CI: 1.83-37.41; P = 0.005, OR: 7.33; 95% CI: 
      1.63-33.02; P = 0.005; and OR: 10.29; 95% CI: 1.45-72.81; P = 0.029). In contrast 
      to the LTG-induced MPE group, there were no significant differences between HLA 
      alleles and LTG-induced SCAR group. Conclusion:HLA-A( *)02:07 and HLA-B( *)15:02 
      were associated with LTG-induced CADR in Thai patients. We also identified an 
      association between HLA-A( *)33:03, HLA-B( *)15:02, and HLA-B( *)44:03 and 
      LTG-induced MPE in this population. These results suggest that these alleles 
      could be useful screening markers for preventing CADR before LTG treatment in 
      Thai patients, but further replication studies with larger sample sizes are 
      needed.
FAU - Koomdee, Napatrupron
AU  - Koomdee N
AD  - Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 
      Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
AD  - Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center, 
      Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
FAU - Pratoomwun, Jirawat
AU  - Pratoomwun J
AD  - Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 
      Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
AD  - Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center, 
      Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
FAU - Jantararoungtong, Thawinee
AU  - Jantararoungtong T
AD  - Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 
      Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
AD  - Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center, 
      Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
FAU - Theeramoke, Voralaksana
AU  - Theeramoke V
AD  - Manarom Hospital, Bangkok, Thailand.
FAU - Tassaneeyakul, Wichittra
AU  - Tassaneeyakul W
AD  - Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      Thailand.
FAU - Klaewsongkram, Jettanong
AU  - Klaewsongkram J
AD  - Division of Allergy and Clinical Immunology, Skin and Allergy Research Unit, 
      Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      Thailand.
FAU - Rerkpattanapipat, Ticha
AU  - Rerkpattanapipat T
AD  - Division of Allergy Immunology and Rheumatology, Department of Medicine, Faculty 
      of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
FAU - Santon, Siwalee
AU  - Santon S
AD  - Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 
      Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
AD  - Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center, 
      Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
FAU - Puangpetch, Apichaya
AU  - Puangpetch A
AD  - Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 
      Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
AD  - Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center, 
      Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
FAU - Intusoma, Utcharee
AU  - Intusoma U
AD  - Pediatric Neurology Unit, Department of Pediatrics, Faculty of Medicine, Prince 
      of Songkla University, Songkhla, Thailand.
FAU - Tempark, Therdpong
AU  - Tempark T
AD  - Division of Pediatric Dermatology, Department of Pediatrics, Faculty of Medicine, 
      Chulalongkorn University, Bangkok, Thailand.
FAU - Deesudchit, Tayard
AU  - Deesudchit T
AD  - Division of Neurosurgery, Department of Surgery, King Chulalongkorn Memorial 
      Hospital, Bangkok, Thailand.
FAU - Satapornpong, Patompong
AU  - Satapornpong P
AD  - Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 
      Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
AD  - Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center, 
      Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
FAU - Visudtibhan, Anannit
AU  - Visudtibhan A
AD  - Division of Neurology, Department of Pediatrics, Faculty of Medicine, Ramathibodi 
      Hospital, Mahidol University, Bangkok, Thailand.
FAU - Sukasem, Chonlaphat
AU  - Sukasem C
AD  - Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 
      Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
AD  - Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center, 
      Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
AD  - Ramathibodi Multidisciplinary Epilepsy Center, Faculty of Medicine, Ramathibodi 
      Hospital, Mahidol University, Bangkok, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20171129
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC5712579
OTO - NOTNLM
OT  - HLA-A
OT  - HLA-B
OT  - Thai population
OT  - cutaneous adverse drug reactions
OT  - lamotrigine
EDAT- 2017/12/15 06:00
MHDA- 2017/12/15 06:01
PMCR- 2017/11/29
CRDT- 2017/12/15 06:00
PHST- 2017/06/20 00:00 [received]
PHST- 2017/11/13 00:00 [accepted]
PHST- 2017/12/15 06:00 [entrez]
PHST- 2017/12/15 06:00 [pubmed]
PHST- 2017/12/15 06:01 [medline]
PHST- 2017/11/29 00:00 [pmc-release]
AID - 10.3389/fphar.2017.00879 [doi]
PST - epublish
SO  - Front Pharmacol. 2017 Nov 29;8:879. doi: 10.3389/fphar.2017.00879. eCollection 
      2017.