PMID- 29238476
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 20
IP  - 12
DP  - 2017 Dec
TI  - Anti-hyperglycemic and antioxidant potential of Croton bonplandianus. Bail 
      fractions in correlation with polyphenol content.
PG  - 1390-1397
LID - 10.22038/IJBMS.2017.9623 [doi]
AB  - OBJECTIVES: Diabetes mellitus, a carbohydrate metabolic disorder, occurs due to 
      absolute or relative deficiency of insulin. Current treatment strategies involve 
      either preventing or delaying the intestinal absorption of glucose to lower the 
      levels of postprandial hyperglycemia (PPHG). Herbal remedies have been since 
      ancient times for treating diabetes mellitus. Therefore, identifying novel 
      phytocompounds with alpha-amylase and alpha-glucosidase inhibitory activity that would 
      reduce the glucose absorption as well as the rise in postprandial blood glucose 
      level is vital. Consequently, the present study was aimed to investigate the 
      anti-hyperglycemic activity of Croton bonplandianus against these pancreatic 
      enzymes. MATERIALS AND METHODS: The methanol extract of C. bonplandianus leaf was 
      prepared and further fractionation was performed with n-hexane, ethyl acetate and 
      chloroform. The antioxidant activity and anti-hyperglycemic activity of the 
      extracts and its fractions were determined. Further, GC-MS analysis was performed 
      for the leaf extract. RESULTS: The chloroform fraction (ChF) was found to contain 
      highest quantity of polyphenols (114.28 microg/ml of GAE), flavonoids (95.68 microg/ml of 
      quercetin) and tannins (63.80 microg/ml of GAE) and also possessed effective 
      inhibitory activity against alpha amylase (IC(50)95.78 microg/ml) and alpha glucosidase 
      (IC(50) 126.81microg/ml). The antioxidant activity of ChFwas also higher when 
      compared to other fractions. Further, GC-MS analysis of ChF showed the presence 
      of various components that may be responsible for the above mentioned activities. 
      CONCLUSION: The study findings suggest that the components present in the leaves 
      of C. bonplandianus, may provide a potential therapeutic source in developing 
      treatment forhyperglycemia. Further bioassay guided fractionation procedure is 
      required to identify the active constituents.
FAU - Vijayamuthuramalingam, Uma Dharshini Karuppiah
AU  - Vijayamuthuramalingam UDK
AD  - Department of Biomedical Sciences, Sri Ramachandra University, Porur, Chennai, 
      India.
FAU - Rajaram, Rajeswari
AU  - Rajaram R
AD  - Department of Biomedical Sciences, Sri Ramachandra University, Porur, Chennai, 
      India.
FAU - Kuppusamy, Kalaivani Madhavaram
AU  - Kuppusamy KM
AD  - Department of Biomedical Sciences, Sri Ramachandra University, Porur, Chennai, 
      India.
FAU - Jonnalagadda, Bhavana
AU  - Jonnalagadda B
AD  - Department of Biomedical Sciences, Sri Ramachandra University, Porur, Chennai, 
      India.
FAU - Arokiasamy, Sumathy
AU  - Arokiasamy S
AD  - Department of Biomedical Sciences, Sri Ramachandra University, Porur, Chennai, 
      India.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC5723001
OTO - NOTNLM
OT  - Antihyperglycemia
OT  - Polyphenols
OT  - Postprandial hyperglycemia
OT  - alpha-Amylase
OT  - alpha-Glucosidase
EDAT- 2017/12/15 06:00
MHDA- 2017/12/15 06:01
PMCR- 2017/12/01
CRDT- 2017/12/15 06:00
PHST- 2017/12/15 06:00 [entrez]
PHST- 2017/12/15 06:00 [pubmed]
PHST- 2017/12/15 06:01 [medline]
PHST- 2017/12/01 00:00 [pmc-release]
AID - IJBMS-20-1390 [pii]
AID - 10.22038/IJBMS.2017.9623 [doi]
PST - ppublish
SO  - Iran J Basic Med Sci. 2017 Dec;20(12):1390-1397. doi: 10.22038/IJBMS.2017.9623.