PMID- 29239255
OWN - NLM
STAT- MEDLINE
DCOM- 20180817
LR  - 20181113
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 46
IP  - 2
DP  - 2018 Feb
TI  - Nonfunctional pancreatic endocrine tumor in the peripancreatic region in a 
      Chinese patient with multiple endocrine neoplasia type 1.
PG  - 908-915
LID - 10.1177/0300060517728653 [doi]
AB  - Nonfunctional pancreatic neuroendocrine tumors (NF-pNETs) in patients with 
      multiple endocrine neoplasia type 1 (MEN1), which results from a mutation in the 
      MEN1 gene, are commonly small, multiple tumors located in the pancreatic head and 
      inside the pancreatic parenchyma. We herein describe a 35-year-old woman with 
      bone pain and a 7-year history of a prolactinoma. She was clinically diagnosed 
      with MEN1 based on the presence of the prolactinoma and parathyroid hyperplasia. 
      Abdominal computed tomography revealed a 5-cm mass close to the splenic hilum. 
      This soft tissue tumor, which was located outside the pancreatic parenchyma and 
      the tissue origin of which could not be identified preoperatively, was found to 
      be connected to the pancreatic tail. After resection, histological examination 
      revealed a well-differentiated neuroendocrine tumor of pancreatic origin. Genetic 
      testing revealed a heterozygous transition mutation of guanine to adenine at the 
      coding nucleotide 133 in exon 2 (c.133G>A), resulting in an amino acid 
      substitution of glutamic acid with lysine (E45K) in the MEN1 gene. This patient 
      with MEN1 presented with a clinical condition involving a single non-metastatic 
      NF-pNET located outside the pancreatic parenchyma with a missense mutation in the 
      MEN1 gene, which could easily have been misdiagnosed as an accessory spleen.
FAU - Wang, Bao-Ping
AU  - Wang BP
AD  - 1 Department of Endocrinology, Tianjin Medical University General Hospital, 
      Heping District, Tianjin, China.
FAU - Tian, Wei-Jun
AU  - Tian WJ
AD  - 2 Department of General Surgery, Tianjin Medical University General Hospital, 
      Heping District, Tianjin, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - 2 Department of General Surgery, Tianjin Medical University General Hospital, 
      Heping District, Tianjin, China.
FAU - Jiang, Chang-Xin
AU  - Jiang CX
AD  - 3 Department of Pathology, Tianjin Medical University General Hospital, Heping 
      District, Tianjin, China.
FAU - Qu, Hui-Qi
AU  - Qu HQ
AD  - 4 Department of Paediatrics, Division of Endocrinology, 54473 McGill University 
      Health Centre Research Institute, Montreal, Quebec, Canada.
FAU - Zhu, Mei
AU  - Zhu M
AD  - 1 Department of Endocrinology, Tianjin Medical University General Hospital, 
      Heping District, Tianjin, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170914
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Hormone Antagonists)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 3A64E3G5ZO (Bromocriptine)
RN  - Non functioning pancreatic endocrine tumor
SB  - IM
MH  - Adult
MH  - Amino Acid Substitution
MH  - Bone and Bones/physiopathology
MH  - Bromocriptine/therapeutic use
MH  - Female
MH  - Gene Expression
MH  - Hormone Antagonists/therapeutic use
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/diagnostic 
      imaging/genetics/*pathology/surgery
MH  - *Mutation, Missense
MH  - Pain/diagnosis/*physiopathology
MH  - Pancreatic Neoplasms/diagnostic imaging/genetics/*pathology/surgery
MH  - Prolactinoma/diagnostic imaging/drug therapy/genetics/*pathology
MH  - Proto-Oncogene Proteins/*genetics
MH  - Tomography, X-Ray Computed
PMC - PMC5971513
OTO - NOTNLM
OT  - MEN1
OT  - NF-pNET
OT  - metastasis
OT  - missense mutation
OT  - pancreatic
OT  - parenchyma
EDAT- 2017/12/15 06:00
MHDA- 2018/08/18 06:00
PMCR- 2018/02/01
CRDT- 2017/12/15 06:00
PHST- 2017/12/15 06:00 [pubmed]
PHST- 2018/08/18 06:00 [medline]
PHST- 2017/12/15 06:00 [entrez]
PHST- 2018/02/01 00:00 [pmc-release]
AID - 10.1177_0300060517728653 [pii]
AID - 10.1177/0300060517728653 [doi]
PST - ppublish
SO  - J Int Med Res. 2018 Feb;46(2):908-915. doi: 10.1177/0300060517728653. Epub 2017 
      Sep 14.