PMID- 29239917
OWN - NLM
STAT- MEDLINE
DCOM- 20190909
LR  - 20190909
IS  - 1537-4513 (Electronic)
IS  - 1524-9557 (Linking)
VI  - 41
IP  - 4
DP  - 2018 May
TI  - Natural Compounds as Epigenetic Regulators of Human Dendritic Cell-mediated 
      Immune Function.
PG  - 169-180
LID - 10.1097/CJI.0000000000000201 [doi]
AB  - Dendritic cells (DCs) are the most potent professional antigen-presenting cells 
      (APCs) and are poised to capture antigen, migrate to draining lymphoid organs, 
      and postmaturation process. Recent evidences have suggested that tumor 
      microenvironment has an effect on DCs by inactivating various components of the 
      immune system responsible for tumor clearance, eventually leading to 
      tumorigenesis. This inactivation is owed to the epigenetic modifications [ie, 
      microRNA (miRNA)] at the posttranscriptional level, thus regulating the 
      differentiation patterns and functional behavior of DCs. Thus, need of the hour 
      is to develop protocols for ex vivo generation of DCs which may provide a 
      foundation for designing and developing DC-based vaccination for treatment of 
      solid tumors. To achieve this, it is crucial to modulate DCs by identifying 
      miRNAs which may increase the efficacy of DC-based vaccines by reprogramming the 
      immunosuppressive nature of tumor microenvironment. Furthermore, it would be an 
      interesting aspect to check the immunomodulatory potential of natural compounds 
      in reprogramming the immune responses through DCs. Thus, this review aims to 
      improvise the understanding of DC immune biology and miRNAs at genetic level in 
      cancer which can be pivotal for designing novel or improved therapeutic 
      approaches that will allow proper functioning of DCs in patient care. 
      Furthermore, we have highlighted the candidate target molecules and signaling 
      mechanisms having a vital role in the immune-modulatory activities of natural 
      compounds and its derived phytocompounds. This review also establishes a link 
      between miRNA expressions and biological roles of natural compounds modulating 
      the activity of DCs.
FAU - Mirza, Sheefa
AU  - Mirza S
AD  - Department of Life Science, School of Sciences, Gujarat University.
AD  - Department of Cancer Biology, Division of Medicinal Chemistry and 
      Pharmacogenomics, The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, 
      India.
FAU - Shah, Kanisha
AU  - Shah K
AD  - Department of Life Science, School of Sciences, Gujarat University.
FAU - Patel, Shanaya
AU  - Patel S
AD  - Department of Life Science, School of Sciences, Gujarat University.
FAU - Jain, Nayan
AU  - Jain N
AD  - Department of Life Science, School of Sciences, Gujarat University.
FAU - Rawal, Rakesh
AU  - Rawal R
AD  - Department of Life Science, School of Sciences, Gujarat University.
AD  - Department of Cancer Biology, Division of Medicinal Chemistry and 
      Pharmacogenomics, The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, 
      India.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Immunother
JT  - Journal of immunotherapy (Hagerstown, Md. : 1997)
JID - 9706083
RN  - 0 (Biological Products)
SB  - IM
MH  - Animals
MH  - Biological Products/*pharmacology
MH  - DNA Methylation
MH  - Dendritic Cells/*drug effects/*physiology
MH  - Epigenesis, Genetic/*drug effects
MH  - Gene Expression Regulation
MH  - Humans
MH  - Immune System/cytology/immunology/metabolism
MH  - Immunity, Cellular/*drug effects
MH  - Immunomodulation/*drug effects
MH  - Neoplasms/genetics/immunology/metabolism/pathology
MH  - Tumor Microenvironment
EDAT- 2017/12/15 06:00
MHDA- 2019/09/10 06:00
CRDT- 2017/12/15 06:00
PHST- 2017/12/15 06:00 [pubmed]
PHST- 2019/09/10 06:00 [medline]
PHST- 2017/12/15 06:00 [entrez]
AID - 10.1097/CJI.0000000000000201 [doi]
PST - ppublish
SO  - J Immunother. 2018 May;41(4):169-180. doi: 10.1097/CJI.0000000000000201.