PMID- 29240264 OWN - NLM STAT- MEDLINE DCOM- 20180828 LR - 20180828 IS - 1399-3038 (Electronic) IS - 0905-6157 (Linking) VI - 29 IP - 3 DP - 2018 May TI - Longitudinal vitamin D deficiency is inversely related to mite sensitization in early childhood. PG - 254-259 LID - 10.1111/pai.12846 [doi] AB - BACKGROUND: There are few studies addressing the longitudinal analysis of vitamin D deficiency and its impact on the development of atopic diseases in early childhood. METHODS: We investigated 155 children who regularly followed up at our clinic for 5 years as subjects enrolled in a birth cohort study. The pattern of vitamin D levels from birth to 5 years of age was clustered using K-means method in R software. Absolute eosinophil count (AEC), and total serum and specific immunoglobulin E antibodies against food (egg white, milk, and wheat) and inhalant allergens (Dermatophagoides pteronyssinus, Dermatophagoides farina, and Cladosporium herbarum) were measured at 1.5, 3, 4 and 5 years of age. RESULTS: A total of 137 children with serum samples obtained over at least 3 time points during the follow-up period were recruited. Using K-means clustering, the dynamic changes in vitamin D levels were significantly stratified into 3 clusters (cluster A, >/=30 ng/mL, n = 61; cluster B, 20-29.9 ng/mL, n = 53; cluster C, <20 ng/mL, n = 23). Despite no statistical association with atopic diseases, a persistent vitamin D deficiency appeared to be associated with eosinophilia at age 3, and total serum and mite-specific immunoglobulin E (IgE) levels at age 4. Furthermore, an associated higher prevalence of mite sensitization at age 4 was significantly associated with the risk of allergic rhinitis and asthma. CONCLUSIONS: Vitamin D deficiency is inversely associated with AEC and mite-specific IgE levels, which may potentially increase susceptibility to develop allergies including rhinitis and asthma in early childhood. CI - (c) 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. FAU - Chiu, Chih-Yung AU - Chiu CY AUID- ORCID: 0000-0002-6454-968X AD - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - Division of Pediatric Pulmonology, College of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan. AD - Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan. FAU - Su, Kuan-Wen AU - Su KW AD - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan. AD - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan. FAU - Tsai, Ming-Han AU - Tsai MH AD - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan. FAU - Hua, Man-Chin AU - Hua MC AD - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan. FAU - Liao, Sui-Ling AU - Liao SL AD - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan. FAU - Lai, Shen-Hao AU - Lai SH AD - Division of Pediatric Pulmonology, College of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan. AD - Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan. FAU - Chen, Li-Chen AU - Chen LC AD - Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan. AD - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan. FAU - Yao, Tsung-Chieh AU - Yao TC AD - Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan. AD - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan. FAU - Yeh, Kuo-Wei AU - Yeh KW AUID- ORCID: 0000-0002-2499-8050 AD - Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan. AD - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan. FAU - Huang, Jing-Long AU - Huang JL AUID- ORCID: 0000-0001-9280-920X AD - Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan. AD - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180105 PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 RN - 0 (Allergens) RN - 1406-16-2 (Vitamin D) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Allergens/immunology MH - Animals MH - Child, Preschool MH - Cohort Studies MH - Eosinophilia/etiology/immunology MH - Female MH - Humans MH - Hypersensitivity/epidemiology/*etiology MH - Immunoglobulin E/blood MH - Infant MH - Infant, Newborn MH - Longitudinal Studies MH - Male MH - Mites/*immunology MH - Prevalence MH - Taiwan/epidemiology MH - Vitamin D/*blood MH - Vitamin D Deficiency/*complications OTO - NOTNLM OT - allergic sensitization OT - asthma OT - eosinophil OT - longitudinal vitamin D deficiency EDAT- 2017/12/15 06:00 MHDA- 2018/08/29 06:00 CRDT- 2017/12/15 06:00 PHST- 2017/12/06 00:00 [accepted] PHST- 2017/12/15 06:00 [pubmed] PHST- 2018/08/29 06:00 [medline] PHST- 2017/12/15 06:00 [entrez] AID - 10.1111/pai.12846 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2018 May;29(3):254-259. doi: 10.1111/pai.12846. Epub 2018 Jan 5.