PMID- 2924116
OWN - NLM
STAT- MEDLINE
DCOM- 19890427
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 478
IP  - 1
DP  - 1989 Jan 23
TI  - Alterations of muscarinic cholinergic receptors in the hippocampal formation of 
      stressed rat: in vitro quantitative autoradiographic analysis.
PG  - 187-92
AB  - Alterations in muscarinic cholinergic (mACh) binding sites in the hippocampal 
      formation of rats after immobilization stress (IM-stress) lasting 0.5 or 3 h were 
      quantitated using a computer-assisted image analysis system on autoradiograms 
      following labeling of frozen sections with [3H]quinuclidinyl benzilate (QNB). The 
      concentration of acetylcholine (ACh) in the rat hippocampus after IM-stress was 
      also measured and showed no significant change compared to control. IM-stress for 
      0.5 h produced significant increases in the concentration of mACh binding sites 
      in the whole hippocampal formation and in two subdivisions studied (CA1 plus CA2 
      and dentate gyrus); after 3 h of stress, the increase remained significant only 
      in the dentate gyrus. These findings suggest that IM-stress induce a 
      hypersensitivity of the septo-hippocampal cholinergic system and the 
      'up-regulation' of postsynaptic mACh receptors is more lasting in the dentate 
      gyrus than in the hippocampus as a whole.
FAU - Mizukawa, K
AU  - Mizukawa K
AD  - Department of Anatomy, Okayama University Medical School, Japan.
FAU - Takayama, H
AU  - Takayama H
FAU - Sato, H
AU  - Sato H
FAU - Ota, Z
AU  - Ota Z
FAU - Haba, K
AU  - Haba K
FAU - Ogawa, N
AU  - Ogawa N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Receptors, Muscarinic)
RN  - 6581-06-2 (Quinuclidinyl Benzilate)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Animals
MH  - Autoradiography
MH  - Cholinergic Fibers/*metabolism
MH  - Hippocampus/*metabolism/physiopathology
MH  - Male
MH  - Quinuclidinyl Benzilate/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Muscarinic/*metabolism
MH  - Restraint, Physical
MH  - Stress, Physiological/*metabolism
OID - NASA: 89167622
EDAT- 1989/01/23 00:00
MHDA- 1989/01/23 00:01
CRDT- 1989/01/23 00:00
PHST- 1989/01/23 00:00 [pubmed]
PHST- 1989/01/23 00:01 [medline]
PHST- 1989/01/23 00:00 [entrez]
AID - 0006-8993(89)91496-0 [pii]
AID - 10.1016/0006-8993(89)91496-0 [doi]
PST - ppublish
SO  - Brain Res. 1989 Jan 23;478(1):187-92. doi: 10.1016/0006-8993(89)91496-0.