PMID- 29242143 OWN - NLM STAT- MEDLINE DCOM- 20181015 LR - 20181015 IS - 1440-1592 (Electronic) IS - 1323-8930 (Linking) VI - 67 IP - 3 DP - 2018 Jul TI - Increased ratio of pollock roe-specific IgE to salmon roe-specific IgE levels is associated with a positive reaction to cooked pollock roe oral food challenge. PG - 364-370 LID - S1323-8930(17)30166-1 [pii] LID - 10.1016/j.alit.2017.11.005 [doi] AB - BACKGROUND: Anaphylaxis and immediate-type fish roe allergies have been reported worldwide, and, in Japan, fish roe is the sixth most common food allergen. No oral food challenges (OFCs) have used pollock roe (PR), which is reported to have high cross-reactivity with salmon roe (SR). Therefore, we administered an OFC using cooked PR to evaluate PR- and SR-specific immunoglobulin E (IgE) levels and allergic reactions in patients with PR sensitivity. METHODS: This retrospective study evaluating patient characteristics and responses to OFCs was conducted with 10-20 g of cooked PR, between April 2006 and November 2016. RESULTS: We assessed 51 patients (median age: 6.8 years). All had PR sensitization, 6 (12%) with a history of immediate reactions to PR, and 18 (35%) of immediate reactions to SR. Median PR-specific and SR-specific IgE values were 3.4 kUA/L and 9.9 kUA/L, respectively. Seven patients (14%) had a positive OFC. There was no anaphylaxis. Induced symptoms were mild and included localized urticaria, throat pruritus, intermittent cough, and mild abdominal pain. We treated one patient with mild abdominal pain with oral antihistamines. There were no significant differences in history of immediate reaction to PR and PR-specific IgE titers between OFC-positive and OFC-negative patients, although significant differences were found for PR-specific IgE titers adjusted for SR-specific IgE (p = 0.025) and PR-specific IgE/SR-specific IgE ratio (p = 0.009). CONCLUSIONS: Increased PR-specific IgE/SR-specific IgE ratio or PR-specific IgE levels adjusted for SR-specific IgE levels were risk factors for OFC positivity. CI - Copyright (c) 2017 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved. FAU - Makita, Eishi AU - Makita E AD - Department of Pediatrics, Sagamihara National Hospital, Kanagawa, Japan. FAU - Yanagida, Noriyuki AU - Yanagida N AD - Department of Pediatrics, Sagamihara National Hospital, Kanagawa, Japan. FAU - Sato, Sakura AU - Sato S AD - Department of Allergy, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan. FAU - Asaumi, Tomoyuki AU - Asaumi T AD - Department of Pediatrics, Sagamihara National Hospital, Kanagawa, Japan. FAU - Ebisawa, Motohiro AU - Ebisawa M AD - Department of Allergy, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan. Electronic address: m-ebisawa@sagamihara-hosp.gr.jp. LA - eng PT - Journal Article DEP - 20171211 PL - England TA - Allergol Int JT - Allergology international : official journal of the Japanese Society of Allergology JID - 9616296 RN - 0 (Allergens) SB - IM MH - Allergens/*administration & dosage MH - Animals MH - Child MH - Child, Preschool MH - Cross Reactions MH - Eggs/*adverse effects MH - Female MH - Food Hypersensitivity/*diagnosis/immunology MH - Gadiformes/immunology MH - Humans MH - Immunologic Tests/*methods MH - Male MH - Retrospective Studies MH - Salmon/immunology OTO - NOTNLM OT - Fish roe OT - Food allergy OT - Food challenge OT - IgE OT - Pollock roe EDAT- 2017/12/16 06:00 MHDA- 2018/10/16 06:00 CRDT- 2017/12/16 06:00 PHST- 2017/08/06 00:00 [received] PHST- 2017/10/23 00:00 [revised] PHST- 2017/10/30 00:00 [accepted] PHST- 2017/12/16 06:00 [pubmed] PHST- 2018/10/16 06:00 [medline] PHST- 2017/12/16 06:00 [entrez] AID - S1323-8930(17)30166-1 [pii] AID - 10.1016/j.alit.2017.11.005 [doi] PST - ppublish SO - Allergol Int. 2018 Jul;67(3):364-370. doi: 10.1016/j.alit.2017.11.005. Epub 2017 Dec 11.