PMID- 29243264
OWN - NLM
STAT- MEDLINE
DCOM- 20180717
LR  - 20181202
IS  - 1423-0410 (Electronic)
IS  - 0042-9007 (Linking)
VI  - 113
IP  - 2
DP  - 2018 Feb
TI  - Prolonged platelet storage associated with increased frequency of 
      transfusion-related adverse events.
PG  - 170-176
LID - 10.1111/vox.12622 [doi]
AB  - BACKGROUND: Platelets (PLTs) have been associated with the highest rate of 
      transfusion-associated adverse events (AEs) among all blood products. Most of 
      PLT-associated AEs are considered to have an inflammatory mechanism. However, it 
      is still unclear whether prolonged storage of platelets is associated with an 
      increased rate of transfusion-related AEs, especially in the era of universal 
      prestorage leucoreduction. METHODS/MATERIALS: In this retrospective study, 52 649 
      PLT products consisting of about 80% apheresis PLTs and 20% whole blood-derived 
      (WBD) PLTs were transfused to 9415 patients from July 2011 to March 2017. All the 
      PLTs were leucoreduced prior to storage. All but 69 units of the apheresis PLTs 
      were irradiated and none of WBD PLTs were irradiated. During this period, a total 
      of 284 AEs that were reported to the transfusion service were analysed. RESULTS: 
      Univariate and multivariate logistic analyses showed that apheresis/irradiated 
      PLTs and PLT age were associated with a significantly increased frequency of 
      inflammation type AEs (OR (95% CI): 2.24 (1.32, 4.15) and 1.30 (1.12, 1.52), 
      respectively). There was a significant increase in the frequency of inflammation 
      AEs associated with prolonged storage of apheresis/irradiated PLTs [OR (95% CI): 
      1.26 (1.03, 1.53)]. In contrast, there was no association between allergic 
      symptoms and PLT age. Moreover, the frequency of transfusion AEs associated with 
      apheresis/irradiated PLTs (57.2/10 000) was significantly higher than that of 
      WBD/nonirradiated PLTs (26.0/10 000) (P < 0.01). CONCLUSION: Prolonged storage of 
      apheresis/irradiated PLTs was associated with a higher frequency of inflammation 
      AEs. Apheresis/irradiated PLTs caused more AEs than WBD/nonirradiated PLTs.
CI  - (c) 2017 International Society of Blood Transfusion.
FAU - Losos, M
AU  - Losos M
AD  - Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 
      USA.
FAU - Biller, E
AU  - Biller E
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, OH, USA.
FAU - Li, J
AU  - Li J
AD  - College of Pharmacy, The Ohio State University Wexner Medical Center, Columbus, 
      OH, USA.
FAU - Blower, L
AU  - Blower L
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, OH, USA.
FAU - Hamad, D
AU  - Hamad D
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, OH, USA.
FAU - Patel, G
AU  - Patel G
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, OH, USA.
FAU - Scrape, S
AU  - Scrape S
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, OH, USA.
FAU - Cataland, S
AU  - Cataland S
AD  - Department of Internal Medicine, Division of Hematology, The Ohio State 
      University Wexner Medical Center, Columbus, OH, USA.
FAU - Chen, J
AU  - Chen J
AUID- ORCID: 0000-0002-9302-1235
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, OH, USA.
LA  - eng
PT  - Journal Article
DEP - 20171215
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Preservation/*adverse effects/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Platelet Transfusion/*adverse effects/methods
MH  - Transfusion Reaction/*etiology/prevention & control
OTO - NOTNLM
OT  - blood safety
OT  - platelet transfusion
OT  - transfusion reactions
EDAT- 2017/12/16 06:00
MHDA- 2018/07/18 06:00
CRDT- 2017/12/16 06:00
PHST- 2017/07/02 00:00 [received]
PHST- 2017/09/19 00:00 [revised]
PHST- 2017/11/07 00:00 [accepted]
PHST- 2017/12/16 06:00 [pubmed]
PHST- 2018/07/18 06:00 [medline]
PHST- 2017/12/16 06:00 [entrez]
AID - 10.1111/vox.12622 [doi]
PST - ppublish
SO  - Vox Sang. 2018 Feb;113(2):170-176. doi: 10.1111/vox.12622. Epub 2017 Dec 15.