PMID- 29243873
OWN - NLM
STAT- MEDLINE
DCOM- 20190528
LR  - 20200930
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Linking)
VI  - 177
IP  - 2
DP  - 2018 Mar
TI  - A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF 
      expression and function with relevance to major depressive disorder.
PG  - 143-167
LID - 10.1002/ajmg.b.32616 [doi]
AB  - Major depressive disorder (MDD) is a mood disorder that affects behavior and 
      impairs cognition. A gene potentially important to this disorder is the brain 
      derived neurotrophic factor (BDNF) as it is involved in processes controlling 
      neuroplasticity. Various mechanisms exist to regulate BDNF's expression level, 
      subcellular localization, and sorting to appropriate secretory pathways. 
      Alterations to these processes by genetic factors and negative stressors can 
      dysregulate its expression, with possible implications for MDD. Here, we review 
      the mechanisms governing the regulation of BDNF expression, and discuss how 
      disease-associated single nucleotide polymorphisms (SNPs) can alter these 
      mechanisms, and influence MDD. As negative stressors increase the likelihood of 
      MDD, we will also discuss the impact of these stressors on BDNF expression, the 
      cellular effect of such a change, and its impact on behavior in animal models of 
      stress. We will also describe epigenetic processes that mediate this change in 
      BDNF expression. Similarities in BDNF expression between animal models of stress 
      and those in MDD will be highlighted. We will also contrast epigenetic patterns 
      at the BDNF locus between animal models of stress, and MDD patients, and address 
      limitations to current clinical studies. Future work should focus on validating 
      current genetic and epigenetic findings in tightly controlled clinical studies. 
      Regions outside of BDNF promoters should also be explored, as should other 
      epigenetic marks, to improve identification of biomarkers for MDD.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Hing, Benjamin
AU  - Hing B
AUID- ORCID: 0000-0002-9437-6118
AD  - Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa 
      City, Iowa.
FAU - Sathyaputri, Leela
AU  - Sathyaputri L
AD  - Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa 
      City, Iowa.
FAU - Potash, James B
AU  - Potash JB
AD  - Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa 
      City, Iowa.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171215
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/*genetics/metabolism
MH  - Cognition/physiology
MH  - DNA Methylation
MH  - Depressive Disorder, Major/*genetics/metabolism
MH  - Epigenesis, Genetic
MH  - Humans
MH  - Mood Disorders/genetics/metabolism
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
OTO - NOTNLM
OT  - DNA methylation
OT  - brain-derived neurotrophic factor
OT  - histone modification
OT  - mood disorders
OT  - negative stressors
EDAT- 2017/12/16 06:00
MHDA- 2019/05/29 06:00
CRDT- 2017/12/16 06:00
PHST- 2017/04/10 00:00 [received]
PHST- 2017/11/21 00:00 [accepted]
PHST- 2017/12/16 06:00 [pubmed]
PHST- 2019/05/29 06:00 [medline]
PHST- 2017/12/16 06:00 [entrez]
AID - 10.1002/ajmg.b.32616 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2018 Mar;177(2):143-167. doi: 
      10.1002/ajmg.b.32616. Epub 2017 Dec 15.