PMID- 29245276
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 49
DP  - 2017 Dec
TI  - Clinical and microbiological characteristics of vancomycin-resistant Enterococcus 
      faecium bloodstream infection in Central Taiwan.
PG  - e9000
LID - 10.1097/MD.0000000000009000 [doi]
LID - e9000
AB  - Bloodstream infections (BSIs) due to vancomycin-resistant Enterococcus faecium 
      (VREfae) remain a therapeutic challenge. This study aimed to evaluate mortality 
      from BSIs due to VREfae in Central Taiwan.We retrospectively analyzed patients 
      with significant VREfae BSIs in the Changhua Christian Hospital System between 
      January 1, 2010 and December 31, 2014.Of the 152 patients with Enterococcal BSI, 
      56 patients (36.8%) were admitted to intensive care units (ICUs) at the onset of 
      BSI and 20 (13.2%) patients were associated with polymicrobial bacteremia. VREfae 
      BSI was observed in 36 (23.7%) patients. Van A (100%) is the prevalence genotype, 
      and ST 17 (41.7%) is the predominant ST type among 36 VREfae isolates during the 
      study period. The 30-day mortality rate was 13.2% (20/152). The multivariate 
      logistic regression analysis showed that the onset of VREfae BSI in the ICU (odds 
      ratio [OR] = 4.2, 95% confidence interval [CI] = 1.7-10.0, P = .002) was a 
      significant risk factor for 30-day mortality, whereas an appropriate 
      antimicrobial therapy was a protective factor for 30-day mortality (OR = 0.33, 
      95% CI = 0.14-0.79, P = .013).Our results underscore the need to assist patients 
      who are admitted to ICUs with VREfae BSIs. We emphasize the use of an appropriate 
      antimicrobial therapy for VREfae BSI with the aim to treat more patients with 
      these infections.
FAU - Chen, Chang-Hua
AU  - Chen CH
AD  - Center of Infection Prevention and Control Division of Infectious Diseases, 
      Department of Internal Medicine, Yuanlin Christian Hospital, Changhua Department 
      of Nursing, College of Medicine & Nursing, Hung Kuang University, Sha-lu 
      District, Taichung Epidemiology and Biostatics Center, Changhua Christian 
      Hospital Department of Internal Medicine,Yuanlin Christian Hospital, Changhua, 
      Taiwan.
FAU - Lin, Li-Chen
AU  - Lin LC
FAU - Chang, Yu-Jun
AU  - Chang YJ
FAU - Chang, Chih-Yen
AU  - Chang CY
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Bacteremia/drug therapy/epidemiology/*microbiology
MH  - Bacteriological Techniques
MH  - *Enterococcus faecium
MH  - Female
MH  - Genotype
MH  - Gram-Positive Bacterial Infections/drug therapy/epidemiology/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Taiwan/epidemiology
MH  - *Vancomycin Resistance
MH  - Young Adult
PMC - PMC5728891
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2017/12/17 06:00
MHDA- 2018/01/06 06:00
PMCR- 2017/12/08
CRDT- 2017/12/17 06:00
PHST- 2017/12/17 06:00 [entrez]
PHST- 2017/12/17 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
PHST- 2017/12/08 00:00 [pmc-release]
AID - 00005792-201712080-00065 [pii]
AID - MD-D-17-00755 [pii]
AID - 10.1097/MD.0000000000009000 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(49):e9000. doi: 10.1097/MD.0000000000009000.