PMID- 29246025
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 59
DP  - 2017 Nov 21
TI  - miRNA and lncRNA as biomarkers in cholangiocarcinoma(CCA).
PG  - 100819-100830
LID - 10.18632/oncotarget.19044 [doi]
AB  - The microRNAs are a group of 20 nucleotides-long non-coding RNAs. By binding to 
      the 3'UTR region of target mRNA, microRNAs can perform extensive actions 
      mediating gene expression at post-trancriptional stages. It makes microRNAs serve 
      as very crucial regulators in various biological progress including 
      carcinogenesis. Long non-coding RNAs, however, are a subgroup of RNA with the 
      length of 200 nucleotides. Unlike microRNAs, long non-coding RNAs can form 
      secondary of tertiary domain based on their length. With the ability of directly 
      interacting with DNA, RNA, protein, long non-coding RNAs have promoting or 
      inhibitive functions in gene expression regulation. Furthermore, the abnormal 
      expression of certain long non-coding RNAs has roused people's interest in the 
      role of long non-coding RNAs in tumorigenesis. Although the connection between 
      microRNA/long non-coding RNA and CCA has been a hot field to researchers, the 
      link between molecular mechanism and clinical outcome has been barely built. This 
      review takes a retrospect at the latest researches on the link between 
      microRNA/long non-coding RNA and cholangiocarcinoma and the potential of 
      microRNA/long non-coding RNA serving as distinctive biomarkers for CCA in 
      clinical practice.
FAU - Zheng, Bo
AU  - Zheng B
AD  - International Cooperation Laboratory on Signal Transduction, Eastern 
      Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 
      200438, P.R. China.
AD  - National Center for Liver Cancer, Shanghai 201805, P.R. China.
FAU - Jeong, Seogsong
AU  - Jeong S
AD  - Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai 200127, P.R. China.
FAU - Zhu, Yanjing
AU  - Zhu Y
AD  - International Cooperation Laboratory on Signal Transduction, Eastern 
      Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 
      200438, P.R. China.
AD  - National Center for Liver Cancer, Shanghai 201805, P.R. China.
FAU - Chen, Lei
AU  - Chen L
AD  - International Cooperation Laboratory on Signal Transduction, Eastern 
      Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 
      200438, P.R. China.
AD  - National Center for Liver Cancer, Shanghai 201805, P.R. China.
FAU - Xia, Qiang
AU  - Xia Q
AD  - Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai 200127, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170706
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5725067
OTO - NOTNLM
OT  - biomarker
OT  - cholangiocarcinoma
OT  - lncRNA
OT  - miRNA
OT  - prediction
COIS- CONFLICTS OF INTEREST The authors declared no competing financial interests 
      exist.
EDAT- 2017/12/17 06:00
MHDA- 2017/12/17 06:01
PMCR- 2017/11/21
CRDT- 2017/12/17 06:00
PHST- 2017/05/09 00:00 [received]
PHST- 2017/06/19 00:00 [accepted]
PHST- 2017/12/17 06:00 [entrez]
PHST- 2017/12/17 06:00 [pubmed]
PHST- 2017/12/17 06:01 [medline]
PHST- 2017/11/21 00:00 [pmc-release]
AID - 19044 [pii]
AID - 10.18632/oncotarget.19044 [doi]
PST - epublish
SO  - Oncotarget. 2017 Jul 6;8(59):100819-100830. doi: 10.18632/oncotarget.19044. 
      eCollection 2017 Nov 21.