PMID- 29246538
OWN - NLM
STAT- MEDLINE
DCOM- 20180129
LR  - 20180129
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 645
DP  - 2018 Mar 1
TI  - Sumoylation and ubiquitylation crosstalk in the control of DeltaNp63alpha protein 
      stability.
PG  - 34-40
LID - S0378-1119(17)31071-5 [pii]
LID - 10.1016/j.gene.2017.12.018 [doi]
AB  - DeltaNp63alpha is finely and strictly regulated during embryogenesis and differentiation. 
      DeltaNp63alpha is the only p63 isoform degraded by the proteasome after Ubiquitin and 
      SUMO (Small Ubiquitin-like MOdifier) conjugation. Here, we show that p63 
      ubiquitylation per se is not the signal triggering p63 proteasomal degradation. 
      Taking advantage of natural DeltaNp63alpha mutants isolated by patients with Split Hand 
      and Foot Malformation IV syndrome, we found that SUMO and Ub modifications are 
      not redundant and both are required to guarantee efficient DeltaNp63alpha degradation. 
      Here, we present evidence that sumoylation and ubiquitylation of DeltaNp63alpha are 
      strongly intertwined, and none of the two can efficiently occur if the other is 
      impaired.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Ranieri, Michela
AU  - Ranieri M
AD  - Department of Developmental and Molecular Biology Albert Einstein College of 
      Medicine, United States.
FAU - Vivo, Maria
AU  - Vivo M
AD  - Dipartimento di Biologia, Universita degli Studi di Napoli "Federico II", Italy. 
      Electronic address: maria.vivo@unina.it.
FAU - De Simone, Marco
AU  - De Simone M
AD  - Istituto Nazionale Genetica Molecolare INGM Milan, Italy.
FAU - Guerrini, Luisa
AU  - Guerrini L
AD  - Department of Biosciences, University of Milano, Italy.
FAU - Pollice, Alessandra
AU  - Pollice A
AD  - Dipartimento di Biologia, Universita degli Studi di Napoli "Federico II", Italy.
FAU - La Mantia, Girolama
AU  - La Mantia G
AD  - Dipartimento di Biologia, Universita degli Studi di Napoli "Federico II", Italy.
FAU - Calabro, Viola
AU  - Calabro V
AD  - Dipartimento di Biologia, Universita degli Studi di Napoli "Federico II", Italy.
LA  - eng
PT  - Journal Article
DEP - 20171212
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Small Ubiquitin-Related Modifier Proteins)
RN  - 0 (TP63 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 0 (Ubiquitin)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - Cell Line
MH  - HEK293 Cells
MH  - Humans
MH  - Limb Deformities, Congenital/genetics
MH  - Molecular Weight
MH  - Mutation
MH  - Proteasome Endopeptidase Complex/chemistry/metabolism
MH  - Protein Stability
MH  - Small Ubiquitin-Related Modifier Proteins/metabolism
MH  - Sumoylation
MH  - Transcription Factors/*chemistry/genetics/*metabolism
MH  - Tumor Suppressor Proteins/*chemistry/genetics/*metabolism
MH  - Ubiquitin/metabolism
MH  - Ubiquitination
OTO - NOTNLM
OT  - Differentiation
OT  - GAM1
OT  - SFHM-IV syndrome
OT  - SUMO
OT  - Ubc9
OT  - p14ARF
EDAT- 2017/12/17 06:00
MHDA- 2018/01/30 06:00
CRDT- 2017/12/17 06:00
PHST- 2017/06/30 00:00 [received]
PHST- 2017/12/05 00:00 [revised]
PHST- 2017/12/11 00:00 [accepted]
PHST- 2017/12/17 06:00 [pubmed]
PHST- 2018/01/30 06:00 [medline]
PHST- 2017/12/17 06:00 [entrez]
AID - S0378-1119(17)31071-5 [pii]
AID - 10.1016/j.gene.2017.12.018 [doi]
PST - ppublish
SO  - Gene. 2018 Mar 1;645:34-40. doi: 10.1016/j.gene.2017.12.018. Epub 2017 Dec 12.