PMID- 29247376
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20181113
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 64
IP  - 2
DP  - 2018 Feb
TI  - Neurotrophin Expression in Lymphocytes: a Powerful Indicator of Degeneration in 
      Parkinson's Disease, Amyotrophic Lateral Sclerosis and Ataxia.
PG  - 224-232
LID - 10.1007/s12031-017-1014-x [doi]
AB  - Deregulated neurotrophin is an etiological factor in the pathology of 
      neurodegenerative diseases (ND) that are clinically different entities but 
      characterised by similar limb dysfunction. Earlier validation of peripheral 
      biomarkers can provide significant translational benefit to ND patients. We 
      analysed brain-derived neurotrophic factor (BDNF)-tropomyosin possessing 
      tyrosine-related kinase (Trk B) and its key downstream proteins which are 
      implicated in ND such as Parkinson's disease (PD), amyotrophic lateral sclerosis 
      (ALS) and ataxia. Blood from ND patients with PD, ALS and Ataxia with movement 
      dysfunctions were obtained to analyse mRNA and protein expressions of the 
      above mentioned factors in lymphocytes. The mRNA and protein expression of 
      BDNF-Trk B and its key downstream molecules showed a significant variation when 
      compared to control and among NDs. The study intends to show that on identifying 
      the variation of these key molecules in the blood samples of patients with ND can 
      serve as early diagnostic candidates. Thus by intervening, the neurotrophins and 
      their pathways can help in early diagnosis and optimising levels of diagnostic 
      certainty.
FAU - Sadanand, Anjana
AU  - Sadanand A
AD  - Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamil 
      Nadu, -600025, India.
FAU - Janardhanan, Anjali
AU  - Janardhanan A
AD  - Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamil 
      Nadu, -600025, India.
FAU - Vanisree, A J
AU  - Vanisree AJ
AUID- ORCID: 0000-0003-4942-9871
AD  - Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamil 
      Nadu, -600025, India. journalsvuom@gmail.com.
FAU - Pavai, Thamil
AU  - Pavai T
AD  - Department of Neurology and Neurosurgery, Madras Medical College, Chennai, Tamil 
      Nadu, -600003, India.
LA  - eng
GR  - GCCO/A-2/UGC-MERITORIOUS /2012/1; Dated: 02/04/2012)./University Grants 
      Commission (IN)-Basic scientific resarch/
PT  - Journal Article
DEP - 20171216
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Amyotrophic Lateral Sclerosis/*blood
MH  - Ataxia/*blood
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/blood/genetics/*metabolism
MH  - Cells, Cultured
MH  - Female
MH  - Humans
MH  - Lymphocytes/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*blood
OTO - NOTNLM
OT  - ALS
OT  - BDNF
OT  - Lymphocyte
OT  - Neurodegeneration
OT  - PD
OT  - TrkB
EDAT- 2017/12/17 06:00
MHDA- 2018/08/28 06:00
CRDT- 2017/12/17 06:00
PHST- 2017/09/22 00:00 [received]
PHST- 2017/12/03 00:00 [accepted]
PHST- 2017/12/17 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2017/12/17 06:00 [entrez]
AID - 10.1007/s12031-017-1014-x [pii]
AID - 10.1007/s12031-017-1014-x [doi]
PST - ppublish
SO  - J Mol Neurosci. 2018 Feb;64(2):224-232. doi: 10.1007/s12031-017-1014-x. Epub 2017 
      Dec 16.