PMID- 29248027
OWN - NLM
STAT- MEDLINE
DCOM- 20200703
LR  - 20200703
IS  - 1092-8529 (Print)
IS  - 1092-8529 (Linking)
VI  - 24
IP  - 3
DP  - 2019 Jun
TI  - Peripheral levels of superoxide dismutase and glutathione peroxidase in youths in 
      ultra-high risk for psychosis: a pilot study.
PG  - 333-337
LID - 10.1017/S1092852917000803 [doi]
AB  - IntroductionOxidative stress has been documented in chronic schizophrenia and in 
      the first episode of psychosis, but there are very little data on oxidative 
      stress prior to the disease onset. OBJECTIVE: This work aimed to compare serum 
      levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in young 
      individuals at ultra-high risk (UHR) of developing psychosis with a comparison 
      healthy control group (HC). METHODS: Thirteen UHR subjects and 29 age- and 
      sex-matched healthy controls (HC) were enrolled in this study. Clinical 
      assessment included the Comprehensive Assessment of At-Risk Mental States 
      (CAARMS), the Semi-Structured Clinical Interview for DSM-IV Axis-I (SCID-I) or 
      the Kiddie-SADS-Present and Lifetime Version (K-SADS-PL), and the Global 
      Assessment of Functioning (GAF) scale. Activities of SOD and GPx were measured in 
      serum by the spectrophotometric method using enzyme-linked immunosorbent assay 
      kits. RESULTS: After adjusting for age and years of education, there was a 
      significant lower activity of SOD and lower GPX activity in the UHR group 
      compared to the healthy control group (rate ratio [RR]=0.330, 95% CI 0.187; 
      0.584, p<0.001 and RR=0.509, 95% CI 0.323; 0.803, p=0.004, respectively). 
      There were also positive correlations between GAF functioning scores and GPx and 
      SOD activities. CONCLUSION: Our results suggest that oxidative imbalances could 
      be present prior to the onset of full-blown psychosis, including in at-risk 
      stages. Future studies should replicate and expand these results.
FAU - Zeni-Graiff, Maiara
AU  - Zeni-Graiff M
AD  - 1Department of Psychiatry,Universidade Federal de Sao Paulo (Unifesp),Sao 
      Paulo,Brazil.
FAU - Rios, Adiel C
AU  - Rios AC
AD  - 1Department of Psychiatry,Universidade Federal de Sao Paulo (Unifesp),Sao 
      Paulo,Brazil.
FAU - Maurya, Pawan K
AU  - Maurya PK
AD  - 1Department of Psychiatry,Universidade Federal de Sao Paulo (Unifesp),Sao 
      Paulo,Brazil.
FAU - Rizzo, Lucas B
AU  - Rizzo LB
AD  - 1Department of Psychiatry,Universidade Federal de Sao Paulo (Unifesp),Sao 
      Paulo,Brazil.
FAU - Sethi, Sumit
AU  - Sethi S
AD  - 1Department of Psychiatry,Universidade Federal de Sao Paulo (Unifesp),Sao 
      Paulo,Brazil.
FAU - Yamagata, Ana S
AU  - Yamagata AS
AD  - 1Department of Psychiatry,Universidade Federal de Sao Paulo (Unifesp),Sao 
      Paulo,Brazil.
FAU - Mansur, Rodrigo B
AU  - Mansur RB
AD  - 3Mood Disorders Psychopharmacology Unit (MDPU),University Health 
      Network,Toronto,Canada.
FAU - Pan, Pedro M
AU  - Pan PM
AD  - 5PRISMA Early Intervention Program,Department of Psychiatry,Universidade Federal 
      de Sao Paulo (Unifesp),Sao Paulo,Brazil.
FAU - Asevedo, Elson
AU  - Asevedo E
AD  - 1Department of Psychiatry,Universidade Federal de Sao Paulo (Unifesp),Sao 
      Paulo,Brazil.
FAU - Cunha, Graccielle R
AU  - Cunha GR
AD  - 1Department of Psychiatry,Universidade Federal de Sao Paulo (Unifesp),Sao 
      Paulo,Brazil.
FAU - Zugman, Andre
AU  - Zugman A
AD  - 1Department of Psychiatry,Universidade Federal de Sao Paulo (Unifesp),Sao 
      Paulo,Brazil.
FAU - Bressan, Rodrigo A
AU  - Bressan RA
AD  - 1Department of Psychiatry,Universidade Federal de Sao Paulo (Unifesp),Sao 
      Paulo,Brazil.
FAU - Gadelha, Ary
AU  - Gadelha A
AD  - 1Department of Psychiatry,Universidade Federal de Sao Paulo (Unifesp),Sao 
      Paulo,Brazil.
FAU - Brietzke, Elisa
AU  - Brietzke E
AD  - 1Department of Psychiatry,Universidade Federal de Sao Paulo (Unifesp),Sao 
      Paulo,Brazil.
LA  - eng
PT  - Journal Article
DEP - 20171217
PL  - United States
TA  - CNS Spectr
JT  - CNS spectrums
JID - 9702877
RN  - 0 (Biomarkers)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Disease Susceptibility
MH  - Female
MH  - Glutathione Peroxidase/*blood
MH  - Humans
MH  - Male
MH  - Psychotic Disorders/*blood/diagnosis/epidemiology
MH  - Superoxide Dismutase/*blood
OTO - NOTNLM
OT  - Ultra-high risk
OT  - antioxidant enzymes
OT  - oxidative stress
OT  - prodromal
OT  - psychosis
OT  - schizophrenia
EDAT- 2017/12/19 06:00
MHDA- 2020/07/04 06:00
CRDT- 2017/12/18 06:00
PHST- 2017/12/19 06:00 [pubmed]
PHST- 2020/07/04 06:00 [medline]
PHST- 2017/12/18 06:00 [entrez]
AID - S1092852917000803 [pii]
AID - 10.1017/S1092852917000803 [doi]
PST - ppublish
SO  - CNS Spectr. 2019 Jun;24(3):333-337. doi: 10.1017/S1092852917000803. Epub 2017 Dec 
      17.