PMID- 29248402
OWN - NLM
STAT- MEDLINE
DCOM- 20180830
LR  - 20221207
IS  - 1873-569X (Electronic)
IS  - 0923-1811 (Linking)
VI  - 89
IP  - 3
DP  - 2018 Mar
TI  - Association of HLA class I and class II alleles with bullous pemphigoid in 
      Chinese Hans.
PG  - 258-262
LID - S0923-1811(17)30784-3 [pii]
LID - 10.1016/j.jdermsci.2017.11.014 [doi]
AB  - BACKGROUND: Bullous pemphigoid (BP) is one of the most common autoimmune skin 
      diseases. Associations of genes, especially human leukocyte antigen (HLA)-DQ 
      alleles, with BP indicate that genetic predisposition contributes to the disease. 
      OBJECTIVES: To evaluate the association of HLA class I and HLA class II alleles 
      with susceptibility to BP in the northern Chinese Han population. METHODS: We 
      performed genotype for HLA-A, -B, -C, -G, -DPA1, -DPB1, -DQA1, -DQB1 and -DRB1 
      loci in 105 patients with BP by Sanger sequence-based typing (SBT) method. These 
      data were compared with a local control cohort of 420 age- and sex-matched cases. 
      RESULTS: Among the HLA alleles described herein, the susceptibility alleles 
      associated with a high prevalence of BP were A*11:01 (OR = 1.9 Pc = 0.017); 
      B*37:01 (OR = 8, Pc = 1.811 x 10(-6)); G*01:01 (OR = 3.61, Pc = 2.839 x 10(-15)) 
      and G*01:06 (OR = 2.22, Pc = 0.025); DQA1*01:05 (OR = 4.87, Pc = 5.822 x 10(-5)), 
      DQA1*05:05 (OR = 2.64, Pc = 9.114 x 10(-4)), and DQA1*05:08 (OR = 10.2, 
      Pc = 0.016); DQB1*03:01 (OR = 1.69, Pc = 0.048) and DQB1*05:01 (OR = 3.42, 
      Pc = 7.28 x 10(-6)); and DRB1*10:01 (OR = 6.85, Pc = 2.63 x 10(-6)). To the 
      contrary, HLA-DQA1*01:02 (OR = 0.46, Pc = 8.603 x 10(-4)) and DQA1*01:03 
      (OR = 0.38, Pc = 0.048); DQB1*02:02 (OR = 0.28, Pc = 0.016); and DRB1*07:01 
      (OR = 0.26, Pc = 0.004) had significant associations with protection against BP. 
      In addition, the frequency of haplotype HLA-DRB1*13-DQA1*05-DQB1*03 (OR = 12.32, 
      Pc = 0.026) in BP patients was significantly higher than those in controls. 
      CONCLUSION: Our data demonstrated that the alleles and haplotypes found in this 
      study may be important differential genetic markers for susceptibility to or 
      protection against BP in individuals of northern Chinese Han population.
CI  - Copyright (c) 2017 Japanese Society for Investigative Dermatology. Published by 
      Elsevier B.V. All rights reserved.
FAU - Fang, Hui
AU  - Fang H
AD  - Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 
      127 Changlexi Road, Xi'an 710032, China.
FAU - Shen, Shengxian
AU  - Shen S
AD  - Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 
      127 Changlexi Road, Xi'an 710032, China.
FAU - Zheng, Xiaodong
AU  - Zheng X
AD  - Department of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, 
      Ministry of Education, Anhui Medical University, Hefei, China.
FAU - Dang, Erle
AU  - Dang E
AD  - Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 
      127 Changlexi Road, Xi'an 710032, China.
FAU - Zhang, Jieyu
AU  - Zhang J
AD  - Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 
      127 Changlexi Road, Xi'an 710032, China.
FAU - Shao, Shuai
AU  - Shao S
AD  - Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 
      127 Changlexi Road, Xi'an 710032, China.
FAU - Qiao, Pei
AU  - Qiao P
AD  - Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 
      127 Changlexi Road, Xi'an 710032, China.
FAU - Li, Qiuju
AU  - Li Q
AD  - Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 
      127 Changlexi Road, Xi'an 710032, China.
FAU - Wang, Hua
AU  - Wang H
AD  - Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 
      127 Changlexi Road, Xi'an 710032, China.
FAU - Li, Caixia
AU  - Li C
AD  - Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 
      127 Changlexi Road, Xi'an 710032, China.
FAU - Sun, Liangdan
AU  - Sun L
AD  - Department of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, 
      Ministry of Education, Anhui Medical University, Hefei, China.
FAU - Wang, Gang
AU  - Wang G
AD  - Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 
      127 Changlexi Road, Xi'an 710032, China. Electronic address: xjwgang@fmmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20171202
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/genetics
MH  - China/ethnology
MH  - Female
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pemphigoid, Bullous/*genetics
OTO - NOTNLM
OT  - Bullous pemphigoid
OT  - HLA class I
OT  - HLA class II
OT  - Haplotypes
EDAT- 2017/12/19 06:00
MHDA- 2018/08/31 06:00
CRDT- 2017/12/18 06:00
PHST- 2017/06/22 00:00 [received]
PHST- 2017/11/12 00:00 [revised]
PHST- 2017/11/29 00:00 [accepted]
PHST- 2017/12/19 06:00 [pubmed]
PHST- 2018/08/31 06:00 [medline]
PHST- 2017/12/18 06:00 [entrez]
AID - S0923-1811(17)30784-3 [pii]
AID - 10.1016/j.jdermsci.2017.11.014 [doi]
PST - ppublish
SO  - J Dermatol Sci. 2018 Mar;89(3):258-262. doi: 10.1016/j.jdermsci.2017.11.014. Epub 
      2017 Dec 2.