PMID- 29248633
OWN - NLM
STAT- MEDLINE
DCOM- 20200427
LR  - 20230120
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 203
DP  - 2019 May 1
TI  - Effects of non-contingent cocaine on 3alpha-androstanediol. I. Disruption of male 
      sexual behavior.
PG  - 120-127
LID - S0031-9384(17)30439-0 [pii]
LID - 10.1016/j.physbeh.2017.12.017 [doi]
AB  - One of the hallmarks of drug abuse is a reduction in the salience of, and 
      motivation for, natural rewards, such as mating. The effects of psychostimulants 
      on male sexual interest and performance are conflicting; use of psychostimulants 
      can produce increases in risky sexual behaviors but have detrimental effects on 
      sexual ability. We hypothesize that these conflicting effects on sexual behavior 
      are due to interactions between cocaine and androgens, such as testosterone and 
      its neuroactive metabolite, 3alpha-androstanediol (3alpha-diol). Male rats were 
      administered saline or cocaine (5, 10, or 20mg/kg, i.p.). Motor behavior was 
      observed in the first 30min following drug-administration, and then sexual 
      responding was assessed for 15min. Levels of androgens (testosterone, 3a-diol, 
      and testosterone's aromatized metabolite, estradiol) were measured in circulation 
      and brain regions (frontal cortex, hippocampus, hypothalamus/striatum (hypo/str), 
      and midbrain). Cocaine had no effect on measures of sexual interest (i.e. 
      anogenital investigation). However, cocaine had substantial effects on 
      consummatory sexual behaviors, such as the latency to mount/intromit and the 
      number of sexual contacts. Frontal cortex and hypo/str 3alpha-diol levels were 
      strongly correlated with consummatory behaviors in saline administered rats; 
      however, this relationship was disrupted by cocaine at all dosages, concomitant 
      with impaired sexual behaviors. Additionally, there was a shift in metabolism at 
      low dosages of cocaine to push testosterone metabolism in the midbrain towards 
      3alpha-diol. On the contrary, moderate and high dosages of cocaine shifted 
      testosterone metabolism towards estradiol. These data demonstrate that the 
      association between cortical and hypo/str 3alpha-diol levels and sexual behavior of 
      male rats is disrupted by non-contingent cocaine and that there may be 
      dose-dependent effects of acute cocaine on androgen metabolism.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Kohtz, Amy S
AU  - Kohtz AS
AD  - Dept. of Psychology, The University at Albany, SUNY, Albany, NY, USA.
FAU - Walf, Alicia A
AU  - Walf AA
AD  - Dept. of Psychology, The University at Albany, SUNY, Albany, NY, USA; Cognitive 
      Science Dept., Rensselaer Polytechnic Institute, Troy, NY, USA.
FAU - Frye, Cheryl A
AU  - Frye CA
AD  - Dept. of Psychology, The University at Albany, SUNY, Albany, NY, USA; Biological 
      Sciences, The University at Albany, SUNY, Albany, NY, USA; Center for 
      Neuroscience, The University at Albany, SUNY, Albany, NY, USA; Center for Life 
      Sciences Research, The University at Albany, SUNY, Albany, NY, USA. Electronic 
      address: cafrye@albany.edu.
LA  - eng
GR  - R01 MH067698/MH/NIMH NIH HHS/United States
GR  - R56 MH067698/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20171214
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Androgens)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 3XMK78S47O (Testosterone)
RN  - 4TI98Z838E (Estradiol)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Androgens/blood/*metabolism
MH  - Animals
MH  - Brain/*drug effects/metabolism
MH  - Cocaine/*pharmacology
MH  - Dopamine Uptake Inhibitors/*pharmacology
MH  - Estradiol/blood/metabolism
MH  - Male
MH  - Rats
MH  - Rats, Long-Evans
MH  - Sexual Behavior, Animal/*drug effects
MH  - Testosterone/blood/metabolism
OTO - NOTNLM
OT  - 5alpha-androstane-17beta,3alpha-diol
OT  - Androgens
OT  - Cocaine
OT  - Mating
OT  - Neurosteroids
OT  - Testosterone
EDAT- 2017/12/19 06:00
MHDA- 2020/04/28 06:00
CRDT- 2017/12/18 06:00
PHST- 2017/05/31 00:00 [received]
PHST- 2017/12/03 00:00 [revised]
PHST- 2017/12/14 00:00 [accepted]
PHST- 2017/12/19 06:00 [pubmed]
PHST- 2020/04/28 06:00 [medline]
PHST- 2017/12/18 06:00 [entrez]
AID - S0031-9384(17)30439-0 [pii]
AID - 10.1016/j.physbeh.2017.12.017 [doi]
PST - ppublish
SO  - Physiol Behav. 2019 May 1;203:120-127. doi: 10.1016/j.physbeh.2017.12.017. Epub 
      2017 Dec 14.