PMID- 29248832
OWN - NLM
STAT- MEDLINE
DCOM- 20180814
LR  - 20180814
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 98
DP  - 2018 Feb
TI  - Polyphenol-rich ethyl acetate fraction isolated from Molineria latifolia 
      ameliorates insulin resistance in experimental diabetic rats via IRS1/AKT 
      activation.
PG  - 125-133
LID - S0753-3322(17)33892-1 [pii]
LID - 10.1016/j.biopha.2017.12.002 [doi]
AB  - This study aimed to evaluate the effect of ethyl acetate fraction (EAF) isolated 
      from Molineria latifolia rhizome as dietary interventions for type 2 diabetes 
      mellitus (T2DM) and its underlying molecular mechanisms in vivo. Experimental 
      rats were induced by high fat diet feeding coupled with combined exposure to 
      streptozotocin and nicotinamide. Treatment with EAF improved glucose tolerance 
      and lipid profiles, but the insulin secretion was unaltered. Gene expression 
      analyses on insulin/adipocytokine signalling-related genes demonstrated 
      tissue-specific transcriptional responses. In skeletal muscle and liver tissues, 
      Socs1, Tnf and Mapk8 showed consistent transcript regulation. Furthermore, 
      hepatic translational analyses revealed sensitization on proximal insulin 
      signalling, with reduced expression of IRS1 serine phosphorylation, increased 
      IRS1 tyrosine phosphorylation and increased phospho-AKT (Ser473). The present 
      findings suggested that EAF exerted its effect by modulating insulin signalling, 
      potentially via IRS1/AKT activation. The pharmacological attributes of EAF may 
      implicate its potential therapeutic applications for diabetes management.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Ooi, Der Jiun
AU  - Ooi J
AD  - Nutri-Cosmeceuticals, Nutrigenomics & Nanodelivery Programme, Laboratory of 
      Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 
      Serdang, Selangor, Malaysia.
FAU - Adamu, Hadiza Altine
AU  - Adamu HA
AD  - Nutri-Cosmeceuticals, Nutrigenomics & Nanodelivery Programme, Laboratory of 
      Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 
      Serdang, Selangor, Malaysia.
FAU - Imam, Mustapha Umar
AU  - Imam MU
AD  - Nutri-Cosmeceuticals, Nutrigenomics & Nanodelivery Programme, Laboratory of 
      Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 
      Serdang, Selangor, Malaysia.
FAU - Ithnin, Hairuszah
AU  - Ithnin H
AD  - Department of Pathology, Faculty of Medicine and Health Sciences, Universiti 
      Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
FAU - Ismail, Maznah
AU  - Ismail M
AD  - Nutri-Cosmeceuticals, Nutrigenomics & Nanodelivery Programme, Laboratory of 
      Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 
      Serdang, Selangor, Malaysia. Electronic address: maznahis@upm.edu.my.
LA  - eng
PT  - Journal Article
DEP - 20171227
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Acetates)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Insulin Receptor Substrate Proteins)
RN  - 0 (Irs1 protein, rat)
RN  - 0 (Plant Extracts)
RN  - 0 (Polyphenols)
RN  - 5W494URQ81 (Streptozocin)
RN  - 76845O8NMZ (ethyl acetate)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Acetates/chemistry
MH  - Animals
MH  - Blood Glucose/drug effects
MH  - Diabetes Mellitus, Experimental/*drug therapy/metabolism
MH  - Diabetes Mellitus, Type 2/drug therapy/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Hypoxidaceae/*chemistry
MH  - Insulin/metabolism
MH  - Insulin Receptor Substrate Proteins/*metabolism
MH  - Insulin Resistance/*physiology
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Phosphorylation/drug effects
MH  - Plant Extracts/*pharmacology
MH  - Polyphenols/*pharmacology
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/drug effects
MH  - Streptozocin/pharmacology
OTO - NOTNLM
OT  - Ethyl acetate fraction
OT  - IRS1/AKT activation
OT  - Insulin resistance
OT  - Insulin signaling
OT  - Type 2 diabetes mellitus
EDAT- 2017/12/19 06:00
MHDA- 2018/08/15 06:00
CRDT- 2017/12/18 06:00
PHST- 2017/08/03 00:00 [received]
PHST- 2017/12/01 00:00 [revised]
PHST- 2017/12/01 00:00 [accepted]
PHST- 2017/12/19 06:00 [pubmed]
PHST- 2018/08/15 06:00 [medline]
PHST- 2017/12/18 06:00 [entrez]
AID - S0753-3322(17)33892-1 [pii]
AID - 10.1016/j.biopha.2017.12.002 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 Feb;98:125-133. doi: 10.1016/j.biopha.2017.12.002. Epub 
      2017 Dec 27.