PMID- 29249591
OWN - NLM
STAT- MEDLINE
DCOM- 20180730
LR  - 20180730
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 27
IP  - 4
DP  - 2018 Apr
TI  - Relationship between Cardiac Troponin and Thrombo-Inflammatory Molecules in 
      Prediction of Outcome after Acute Ischemic Stroke.
PG  - 951-956
LID - S1052-3057(17)30602-X [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2017.10.040 [doi]
AB  - BACKGROUND: In patients with acute ischemic stroke (AIS) without cardiovascular 
      complications, we investigated the association of serum concentration of cardiac 
      troponin (high-sensitivity cardiac troponin T [hs-cTnT]) with 
      thrombo-inflammatory markers. METHODS: Thirty-five patients with first-ever AIS 
      were prospectively examined. Serum hs-cTnT was measured 6 and 24 hours after 
      stroke, whereas S100B, high-sensitivity C-reactive protein (hsCRP), soluble CD40 
      ligand, tissue plasminogen activator (tPA), monocyte chemoattractant protein-1 
      (MCP-1), and P-selectin were measured 6 and 72 hours after stroke. Severity of 
      stroke was assessed by the National Institutes of Health Stroke Scale (NIHSS) on 
      admission, 24 hours later, and at discharge. RESULTS: Concentration of MCP-1 at 6 
      hours was higher in the serum of patients with worsened NIHSS by 24 hours 
      (P = .009). Concentration of hs-cTnT at both 6 and 24 hours was higher, if NIHSS 
      worsened by discharge (P = .026 and P = .001). A cutoff value for hs-cTnT 
      measured at T24 greater than or equal to  9.4 predicted worsened NIHSS on 
      discharge with a sensitivity of 81% and a specificity of 74% (area: .808, 
      P = .002). Concentration of hs-cTnT at both 6 and 24 hours was also higher in 
      nonsurvivors compared with survivors (P = .03, respectively), and correlated with 
      (1) tPA levels at 6 hours (P = .001 and P = .002, respectively); (2) MCP-1 
      concentration at 6 hours (P = .01 and P = .015, respectively); and increased 
      hsCRP levels at 72 hours (P = .01, respectively). Concentration of hs-cTnT at 24 
      hours was an independent predictor of worsened NIHSS at discharge (odds ratio: 
      1.58, 95% confidence interval: 1.063-2.370, P = .024). CONCLUSIONS: Elevated 
      concentration of hs-cTnT measured 24 hours after AIS is an independent predictor 
      of progressing neurologic deficit in patients without apparent myocardial damage, 
      and also correlates with acute elevation of tPA and MCP-1.
CI  - Copyright (c) 2018 National Stroke Association. Published by Elsevier Inc. All 
      rights reserved.
FAU - Csecsei, Peter
AU  - Csecsei P
AD  - Department of Neurology, University of Pecs, Pecs, Hungary.
FAU - Pusch, Gabriella
AU  - Pusch G
AD  - Department of Neurology, University of Pecs, Pecs, Hungary.
FAU - Ezer, Erzsebet
AU  - Ezer E
AD  - Department of Anesthesiology and Intensive Care, University of Pecs, Pecs, 
      Hungary.
FAU - Berki, Timea
AU  - Berki T
AD  - Immunology and Biotechnology, University of Pecs, Pecs, Hungary.
FAU - Szapary, Laszlo
AU  - Szapary L
AD  - Department of Neurology, University of Pecs, Pecs, Hungary.
FAU - Illes, Zsolt
AU  - Illes Z
AD  - Department of Neurology, Odense University Hospital, Odense, Denmark; Institute 
      of Clinical Research, University of Southern Denmark, Odense, Denmark.
FAU - Molnar, Tihamer
AU  - Molnar T
AD  - Department of Anesthesiology and Intensive Care, University of Pecs, Pecs, 
      Hungary. Electronic address: tihamermolnar@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20171214
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Troponin T)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Brain Ischemia/*blood/diagnosis/mortality/therapy
MH  - Chemokine CCL2/*blood
MH  - Chi-Square Distribution
MH  - Disability Evaluation
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
MH  - Stroke/*blood/diagnosis/mortality/therapy
MH  - Time Factors
MH  - Tissue Plasminogen Activator/*blood
MH  - Troponin T/*blood
MH  - Up-Regulation
OTO - NOTNLM
OT  - Acute ischemic stroke
OT  - S100B
OT  - high-sensitivity troponin t
OT  - monocyte chemoattractant protein-1
OT  - outcome
EDAT- 2017/12/19 06:00
MHDA- 2018/07/31 06:00
CRDT- 2017/12/19 06:00
PHST- 2017/08/16 00:00 [received]
PHST- 2017/10/11 00:00 [revised]
PHST- 2017/10/31 00:00 [accepted]
PHST- 2017/12/19 06:00 [pubmed]
PHST- 2018/07/31 06:00 [medline]
PHST- 2017/12/19 06:00 [entrez]
AID - S1052-3057(17)30602-X [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2017.10.040 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2018 Apr;27(4):951-956. doi: 
      10.1016/j.jstrokecerebrovasdis.2017.10.040. Epub 2017 Dec 14.