PMID- 29249935
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 11
DP  - 2017
TI  - Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the 
      Starting Point?
PG  - 672
LID - 10.3389/fnins.2017.00672 [doi]
LID - 672
AB  - Recent clinical, genetic and biochemical experimental evidences highlight the 
      existence of common molecular pathways underlying neurodegenerative diseases. In 
      this review, we will explore a key common pathological mechanism, i.e., the loss 
      of neuroprotective factors, across the three major neurodegenerative diseases 
      leading to dementia: Alzheimer's disease (AD), Frontotemporal dementia (FTD) and 
      Lewy body dementia (LBD). We will report evidences that the Brain Derived 
      Neurotrophic Factor (BDNF), the most investigated and characterized brain 
      neurotrophin, progranulin, a multi-functional adipokine with trophic and growth 
      factor properties, and cystatin C, a neuroprotective growth factor, are reduced 
      in AD, FTD, and LBD. Moreover, we will review the molecular mechanism underlying 
      the loss of neuroprotective factors in neurodegenerative diseases leading to 
      dementia, with a special focus on endo-lysosomal pathway and intercellular 
      communication mediated by extracellular vesicles. Exploring the shared 
      commonality of disease mechanisms is of pivotal importance to identify novel 
      potential therapeutic targets and to develop treatments to delay, slow or block 
      disease progression.
FAU - Benussi, Luisa
AU  - Benussi L
AD  - Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio 
      Fatebenefratelli, Brescia, Italy.
FAU - Binetti, Giuliano
AU  - Binetti G
AD  - Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio 
      Fatebenefratelli, Brescia, Italy.
AD  - MAC Memory Center, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 
      Brescia, Italy.
FAU - Ghidoni, Roberta
AU  - Ghidoni R
AD  - Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio 
      Fatebenefratelli, Brescia, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171201
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC5717017
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - BDNF
OT  - Lewy body dementia
OT  - biomarkers
OT  - cystatin C
OT  - frontotemporal dementia
OT  - progranulin
EDAT- 2017/12/19 06:00
MHDA- 2017/12/19 06:01
PMCR- 2017/01/01
CRDT- 2017/12/19 06:00
PHST- 2017/09/20 00:00 [received]
PHST- 2017/11/20 00:00 [accepted]
PHST- 2017/12/19 06:00 [entrez]
PHST- 2017/12/19 06:00 [pubmed]
PHST- 2017/12/19 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2017.00672 [doi]
PST - epublish
SO  - Front Neurosci. 2017 Dec 1;11:672. doi: 10.3389/fnins.2017.00672. eCollection 
      2017.