PMID- 29250038
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 8
DP  - 2017
TI  - Double-Serine Fluoroquinolone Resistance Mutations Advance Major International 
      Clones and Lineages of Various Multi-Drug Resistant Bacteria.
PG  - 2261
LID - 10.3389/fmicb.2017.02261 [doi]
LID - 2261
AB  - The major international sequence types/lineages of methicillin-resistant 
      Staphylococcus aureus (MRSA), extended-spectrum beta-lactamase (ESBL)-producing 
      Klebsiella pneumoniae and ESBL-producing E. coli were demonstrated to have been 
      advanced by favorable fitness balance associated with high-level resistance to 
      fluoroquinolones. The paper shows that favorable fitness in the major 
      STs/lineages of these pathogens was principally attained by the capacity of 
      evolving mutations in the fluoroquinolone-binding serine residues of both the DNA 
      gyrase and topoisomerase IV enzymes. The available information on fitness balance 
      incurred by individual and various combinations of mutations in the enzymes is 
      reviewed in multiple species. Moreover, strong circumstantial evidence is 
      presented that major STs/lineages of other multi-drug resistant bacteria, 
      primarily vancomycin-resistant Enterococcus faecium (VRE), emerged by a similar 
      mechanism. The reason(s) why the major ST/lineage strains of various pathogens 
      proved more adept at evolving favorable mutations than most isolates of the same 
      species remains to be elucidated.
FAU - Fuzi, Miklos
AU  - Fuzi M
AD  - Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary.
FAU - Szabo, Dora
AU  - Szabo D
AD  - Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary.
FAU - Csercsik, Rita
AU  - Csercsik R
AD  - Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171116
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC5715326
OTO - NOTNLM
OT  - International clones
OT  - QRDR
OT  - double-serine
OT  - multiresistant pathogens
OT  - promotion of dissemination
EDAT- 2017/12/19 06:00
MHDA- 2017/12/19 06:01
PMCR- 2017/11/16
CRDT- 2017/12/19 06:00
PHST- 2017/06/30 00:00 [received]
PHST- 2017/11/02 00:00 [accepted]
PHST- 2017/12/19 06:00 [entrez]
PHST- 2017/12/19 06:00 [pubmed]
PHST- 2017/12/19 06:01 [medline]
PHST- 2017/11/16 00:00 [pmc-release]
AID - 10.3389/fmicb.2017.02261 [doi]
PST - epublish
SO  - Front Microbiol. 2017 Nov 16;8:2261. doi: 10.3389/fmicb.2017.02261. eCollection 
      2017.