PMID- 29250665
OWN - NLM
STAT- MEDLINE
DCOM- 20180807
LR  - 20180807
IS  - 2066-8279 (Electronic)
IS  - 1220-0522 (Linking)
VI  - 58
IP  - 3
DP  - 2017
TI  - The correlation between insulin-like growth factor with glycemic control, 
      glomerular filtration rate, blood pressure, hematological changes or body mass 
      index in patients with type 2 diabetes mellitus.
PG  - 857-861
AB  - Insulin-like growth factor (IGF) family is made up of two polypeptides, IGF-I and 
      IGF-II, six specific binding proteins (IGFBPs 1-6) and specific receptors. IGF-I 
      is involved in the regulation of growth and cellular proliferation and has a 
      similar structure to insulin. The major IGF transport function is attributed to 
      IGFBP-3. Some studies have highlighted the association between IGF and diabetes. 
      The aims of this study were to analyze the correlation between IGF with glycemic 
      control, glomerular filtration rate (GFR), blood pressure, hematological changes 
      or body mass index (BMI) in patients with type 2 diabetes mellitus (T2DM). Thirty 
      patients with T2DM and thirty non-diabetic control patients were included in this 
      study. Clinical, anthropometric, biochemical parameters and morphology of blood 
      smear were recorded. Blood pressure was determined by mercury sphygmomanometer. 
      The anthropometric measurement included BMI. The biochemical parameters included 
      fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), GFR, serum IGF-I, 
      IGFBP-3 levels. The IGF-I/IGFBP-3 ratio was evaluated. The plasma glucose was 
      determined enzymatically, HbA1c was determined by high-performance liquid 
      chromatography (HPLC) and GFR was calculated automatically. IGF-I was measured by 
      immunoradiometric assay (ELISA - enzyme-linked immunosorbent assay) and IGFBP-3 
      by sensitivity immunoassay. For the analysis of the morphology of blood smear, 
      May-Grunwald-Giemsa (MGG) was used as staining technique. The microscopic 
      examination was performed initially with the objectives of 10x/20x and 
      subsequently with an immersion objective of 100x. Image acquisition was done 
      after the examination of the preparations obtained with a 40x objective, using 
      Image Pro Plus 6.0 software. In the present study, we observed that T2DM leads to 
      an increase in the IGF-I and IGFBP-3 levels. No relationship was obtain between 
      IGF-I, IGFBP-3 levels and IGF-I/IGFBP-3 ratio with neither parameters studied. 
      The difference of serum IGF-I and IGFBP-3 levels between patients with T2DM and 
      subjects without diabetes showed that IGF-I may be a useful marker for diabetes 
      mellitus and IGFBP-3 for possible complications of this affection.
FAU - NeamTu, Marius Cristian
AU  - NeamTu MC
AD  - Department of Sports Medicine and Kinesiology, University of Craiova, Romania; 
      oanacristineamtu@yahoo.com.
FAU - Avramescu, Elena Taina
AU  - Avramescu ET
FAU - Marcu, Iulia Rahela
AU  - Marcu IR
FAU - Turcu-Stiolica, Adina
AU  - Turcu-Stiolica A
FAU - Boldeanu, Mihail Virgil
AU  - Boldeanu MV
FAU - NeamTu, Oana Maria
AU  - NeamTu OM
FAU - Tudorache, Stefania
AU  - Tudorache S
FAU - Danciulescu Miulescu, Rucsandra Elena
AU  - Danciulescu Miulescu RE
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Rom J Morphol Embryol
JT  - Romanian journal of morphology and embryology = Revue roumaine de morphologie et 
      embryologie
JID - 9112454
RN  - 0 (Blood Glucose)
RN  - 0 (IGF1 protein, human)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Blood Glucose/*metabolism
MH  - Blood Pressure/*physiology
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*blood/*genetics/pathology
MH  - Female
MH  - Glomerular Filtration Rate/*physiology
MH  - Humans
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Middle Aged
EDAT- 2017/12/19 06:00
MHDA- 2018/08/08 06:00
CRDT- 2017/12/19 06:00
PHST- 2017/12/19 06:00 [entrez]
PHST- 2017/12/19 06:00 [pubmed]
PHST- 2018/08/08 06:00 [medline]
AID - 580317857861 [pii]
PST - ppublish
SO  - Rom J Morphol Embryol. 2017;58(3):857-861.