PMID- 29251166
OWN - NLM
STAT- MEDLINE
DCOM- 20190318
LR  - 20190318
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 59
IP  - 9
DP  - 2018 Sep
TI  - Expression of multiple leukemic stem cell markers is associated with poor 
      prognosis in de novo acute myeloid leukemia.
PG  - 2144-2151
LID - 10.1080/10428194.2017.1410888 [doi]
AB  - Leukemic stem cells (LSCs) play a crucial role in chemotherapy resistance in 
      acute myeloid leukemia (AML). Although the association between the expression of 
      individual LSC markers and poor prognosis has been reported, few studies have 
      evaluated the prognostic effect of multiple LSC markers in patients with AML. 
      Herein, we examined three LSC markers (CD25, CD96, and CD123) and the combined 
      effect of their expression on clinical outcome. We retrospectively analyzed 80 
      adult patients with de novo AML who received intensive chemotherapy. Multiple LSC 
      marker expression was significantly associated with shorter three-year overall 
      survival (OS), compared with single or no LSC marker expression (18.2 vs. 65.0%, 
      p < .001). Multivariate analysis showed that the expression of multiple LSC 
      markers remained significant in terms of three-year OS (hazard ratio: 3.80, 
      p = .001). Therefore, the combined evaluation of several LSC markers can predict 
      the clinical outcome in patients with AML.
FAU - Yabushita, Tomohiro
AU  - Yabushita T
AD  - a Department of Hematology , Kobe City Medical Center General Hospital , Hyogo , 
      Japan.
FAU - Satake, Hironaga
AU  - Satake H
AUID- ORCID: 0000-0001-7629-6803
AD  - b Department of Medical Oncology , Kobe City Medical Center General Hospital , 
      Hyogo , Japan.
FAU - Maruoka, Hayato
AU  - Maruoka H
AD  - c Department of Clinical Laboratory , Kobe City Medical Center General Hospital , 
      Hyogo , Japan.
FAU - Morita, Mari
AU  - Morita M
AD  - a Department of Hematology , Kobe City Medical Center General Hospital , Hyogo , 
      Japan.
FAU - Katoh, Daisuke
AU  - Katoh D
AUID- ORCID: 0000-0001-6576-0463
AD  - a Department of Hematology , Kobe City Medical Center General Hospital , Hyogo , 
      Japan.
FAU - Shimomura, Yoshimitsu
AU  - Shimomura Y
AD  - a Department of Hematology , Kobe City Medical Center General Hospital , Hyogo , 
      Japan.
FAU - Yoshioka, Satoshi
AU  - Yoshioka S
AD  - a Department of Hematology , Kobe City Medical Center General Hospital , Hyogo , 
      Japan.
FAU - Morimoto, Takeshi
AU  - Morimoto T
AD  - d Clinical Research Center, Kobe City Medical Center General Hospital , Hyogo , 
      Japan.
AD  - e Department of Clinical Epidemiology , Hyogo College of Medicine , Hyogo , 
      Japan.
FAU - Ishikawa, Takayuki
AU  - Ishikawa T
AD  - a Department of Hematology , Kobe City Medical Center General Hospital , Hyogo , 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20171218
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CD96 antigen)
RN  - 0 (Interleukin-2 Receptor alpha Subunit)
RN  - 0 (Interleukin-3 Receptor alpha Subunit)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antigens, CD/metabolism
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Biomarkers, Tumor/*metabolism
MH  - Female
MH  - Humans
MH  - Interleukin-2 Receptor alpha Subunit/metabolism
MH  - Interleukin-3 Receptor alpha Subunit/metabolism
MH  - Kaplan-Meier Estimate
MH  - Leukemia, Myeloid/*drug therapy/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplastic Stem Cells/*drug effects/metabolism
MH  - Prognosis
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Acute myeloid leukemia
OT  - immunophenotypic studies
OT  - leukemic stem cell
EDAT- 2017/12/19 06:00
MHDA- 2019/03/19 06:00
CRDT- 2017/12/19 06:00
PHST- 2017/12/19 06:00 [pubmed]
PHST- 2019/03/19 06:00 [medline]
PHST- 2017/12/19 06:00 [entrez]
AID - 10.1080/10428194.2017.1410888 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2018 Sep;59(9):2144-2151. doi: 10.1080/10428194.2017.1410888. Epub 
      2017 Dec 18.