PMID- 29252170
OWN - NLM
STAT- MEDLINE
DCOM- 20180820
LR  - 20231213
IS  - 1847-6538 (Electronic)
IS  - 1330-027X (Linking)
VI  - 25
IP  - 3
DP  - 2017 Oct
TI  - HLA-E*0101/0103X is Associated with Susceptibility to Pemphigus Vulgaris: A 
      Case-control Study.
PG  - 189-194
AB  - Pemphigus vulgaris (PV) is a life-threatening, autoimmune blistering disease of 
      the skin and mucous membranes. The relationship between PV and human leukocyte 
      antigen (HLA) has been studied in several reports. Previous reports have 
      demonstrated that HLA-E polymorphisms may have a role in the susceptibility to 
      various autoimmune diseases. Our aim was to evaluate the role of HLA-E gene 
      polymorphisms in the pathogenesis of PV in a Turkish population. A total of 49 
      patients with PV and 50 healthy subjects were enrolled into the study. We 
      sequenced and analyzed the HLA-E gene from genomic DNA obtained from peripheral 
      blood samples of the study groups. HLA-E haplotyping was performed by Sanger 
      sequencing of PCR products of the HLA-E gene and HLA-E alleles determined by 
      using SeqScape(R) software according to the World Health Organization (WHO) 
      Nomenclature Committee for Factors of the HLA System. The frequency of the 
      HLA-E*0101/*0103X genotype in male patients with PV was found to be significantly 
      higher than in men in the control group (P=0.023). In addition, the frequency of 
      the HLA-E*0103X/*0103X genotype was significantly lower in patients with PV than 
      the control group (P=0.040). We also detected that the frequency of the 
      HLA-E*0101/*0103X genotype in patients with mucocutaneous type PV and the 
      frequency of the HLA-E*0101/*0101 genotype in patients with mucosal type PV was 
      significantly higher than those in other types of PV (P=0.001 and P=0.006). The 
      results of this study indicate that carrying the HLA-E*0101/0103X genotype may 
      increase the risk of PV in male patients.
FAU - Altun, Ece
AU  - Altun E
FAU - Yayli, Savas
AU  - Yayli S
AD  - Assoc. Prof. Savas Yayli, MD, Department of Dermatology Faculty of Medicine 
      Karadeniz Technical University, TR 61080 Trabzon, Turkey; savasyayli@gmail.com.
FAU - Toraman, Bayram
AU  - Toraman B
FAU - Arica, Deniz Aksu
AU  - Arica DA
FAU - Kalay, Ersan
AU  - Kalay E
FAU - Selcuk, Leyla Baykal
AU  - Selcuk LB
FAU - Bahadir, Sevgi
AU  - Bahadir S
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Acta Dermatovenerol Croat
JT  - Acta dermatovenerologica Croatica : ADC
JID - 9433781
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pemphigus/*genetics
MH  - Prospective Studies
MH  - Sex Factors
MH  - Turkey
MH  - Young Adult
MH  - HLA-E Antigens
EDAT- 2017/12/19 06:00
MHDA- 2018/08/21 06:00
CRDT- 2017/12/19 06:00
PHST- 2017/12/19 06:00 [entrez]
PHST- 2017/12/19 06:00 [pubmed]
PHST- 2018/08/21 06:00 [medline]
PST - ppublish
SO  - Acta Dermatovenerol Croat. 2017 Oct;25(3):189-194.