PMID- 29254296
OWN - NLM
STAT- MEDLINE
DCOM- 20180222
LR  - 20180222
IS  - 0393-974X (Print)
IS  - 0393-974X (Linking)
VI  - 31
IP  - 4
DP  - 2017 Oct-Dec
TI  - Bioinformatic analysis of pivotal genes associated with septic shock.
PG  - 935-941
AB  - We aimed to identify important genes associated with septic shock and then 
      explore the possibly significant mechanisms of this disease. We downloaded 
      GSE26440 expression data of samples from 98 children with septic shock and 32 
      normal controls from the Gene Expression Omnibus (GEO) database. Differentially 
      expressed genes (DEGs) in samples from patients with septic shock were analyzed 
      in comparison with those in samples from normal controls using a limma package. 
      Functional enrichment analysis for DEGs was performed using DAVID, and a 
      protein–protein interaction (PPI) network was constructed. Upstream transcription 
      factors for DEGs were predicted using the CHIPBase database, and a 
      transcriptional regulation network was constructed. A total of 383 significantly 
      DEGs, including 141 downregulated and 242 upregulated genes, were obtained in the 
      sepsis shock group compared with the normal group. The top five nodes in the PPI 
      network were lysine (K)-specific demethylase 6B (KDM6B), histone deacetylase 2 
      (HDAC2), V-Myc avian myelocytomatosis viral oncogene homolog (MYC), heat-shock 
      protein 90 kDa alpha (cytosolic), class B member 1 (HSP90AB1), and poly 
      (A)-binding protein, cytoplasmic 1 (PABPC1). Nuclear factor 
      kappa-light-chain-enhancer of activated B cells (NFkB) was the transcription 
      factor targeted by most genes, and it regulated the expression of KDM6B, HDAC2, 
      MYC, HSP90AB1, and PABPC1. In conclusion, KDM6B, HDAC2, MYC, HSP90AB1, and PABPC1 
      may play important roles in the development of septic shock. Furthermore, NFkappaB 
      may be involved in septic shock by regulating the expression of KDM6B, HDAC2, 
      MYC, HSP90AB1, and PABPC1.
FAU - Liu, S Y
AU  - Liu SY
AD  - Department of Neurosurgery, Second Hospital, Jilin University, Changchun, China.
FAU - Zhang, L
AU  - Zhang L
AD  - Department of Neurology, Second Hospital, Jilin University, Changchun, China.
FAU - Zhang, Y
AU  - Zhang Y
AD  - Department of Pediatrics, First Hospital, Jilin University, Changchun, China.
FAU - Zhen, Y
AU  - Zhen Y
AD  - Department of Neurosurgery, Northern Jiangsu People’s Hospital, Yangzhou, China.
FAU - Wu, Y F
AU  - Wu YF
AD  - Department of Pneumology, Second Hospital of Jilin University, Changchun, China.
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Biol Regul Homeost Agents
JT  - Journal of biological regulators and homeostatic agents
JID - 8809253
RN  - 0 (HSP90 Heat-Shock Proteins)
RN  - 0 (HSP90AB1 protein, human)
RN  - 0 (MYC protein, human)
RN  - 0 (NF-kappa B)
RN  - 0 (Poly(A)-Binding Protein I)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - EC 1.14.11.- (Jumonji Domain-Containing Histone Demethylases)
RN  - EC 1.14.11.- (KDM6B protein, human)
RN  - EC 3.5.1.98 (HDAC2 protein, human)
RN  - EC 3.5.1.98 (Histone Deacetylase 2)
SB  - IM
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Computational Biology/*methods
MH  - Female
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation
MH  - *Gene Regulatory Networks
MH  - HSP90 Heat-Shock Proteins/genetics/metabolism
MH  - Histone Deacetylase 2/genetics/metabolism
MH  - Humans
MH  - Jumonji Domain-Containing Histone Demethylases/genetics/metabolism
MH  - Male
MH  - NF-kappa B/*genetics/metabolism
MH  - Poly(A)-Binding Protein I/genetics/metabolism
MH  - Protein Interaction Mapping
MH  - Proto-Oncogene Proteins c-myc/genetics/metabolism
MH  - Shock, Septic/*genetics/metabolism/pathology
MH  - *Transcriptome
EDAT- 2017/12/20 06:00
MHDA- 2018/02/23 06:00
CRDT- 2017/12/20 06:00
PHST- 2017/12/20 06:00 [entrez]
PHST- 2017/12/20 06:00 [pubmed]
PHST- 2018/02/23 06:00 [medline]
AID - 11 [pii]
PST - ppublish
SO  - J Biol Regul Homeost Agents. 2017 Oct-Dec;31(4):935-941.