PMID- 29254527 OWN - NLM STAT- MEDLINE DCOM- 20180731 LR - 20180731 IS - 1873-2607 (Electronic) IS - 0749-3797 (Linking) VI - 54 IP - 1S1 DP - 2018 Jan TI - Challenges in Developing U.S. Preventive Services Task Force Child Health Recommendations. PG - S63-S69 LID - S0749-3797(17)30478-6 [pii] LID - 10.1016/j.amepre.2017.08.023 [doi] AB - The U.S. Preventive Services Task Force (USPSTF) uses an objective evidence-based approach to develop recommendations. As part of this process, the USPSTF also identifies important research gaps in scientific evidence. In March 2016, the USPSTF convened an expert panel to discuss its portfolio of child and adolescent recommendations and identify unique methodologic issues when evaluating evidence regarding children and adolescents. The panel identified key domains of challenges, including measuring patient-centered health outcomes; identifying intermediate outcomes predictive of important health outcomes; evaluating the long time horizon needed to assess the balance of benefits and harms; understanding trajectories of growth and development that result in unique windows of time when expected benefits or harms of a preventive service can vary; and considering the perspectives of other individuals who might be affected by the delivery of a preventive service to a child or adolescent. Although the expert panel expressed an interest in being able to make more recommendations for or against preventive services for children and adolescents, it also reinforced the importance of ensuring recommendations were based on sound and sufficient evidence to ensure greatest benefit and minimize unnecessary harms. Accordingly, the need to highlight areas with insufficient evidence is as important as making recommendations. Having identified these key challenges, the USPSTF and other organizations issuing guidelines have an opportunity to advance their methods of evidence synthesis and identified evidence gaps represent important opportunities for researchers and policy makers. CI - Copyright (c) 2017 American Journal of Preventive Medicine. All rights reserved. FAU - Kemper, Alex R AU - Kemper AR AD - U.S. Preventive Services Task Force, current or former member; Nationwide Children's Hospital, Columbus, Ohio. Electronic address: alex.kemper@nationwidechildrens.org. FAU - Krist, Alex H AU - Krist AH AD - U.S. Preventive Services Task Force, current or former member; Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, Virginia. FAU - Tseng, Chien-Wen AU - Tseng CW AD - U.S. Preventive Services Task Force, current or former member; Department of Family Medicine and Community Health, University of Hawaii John A. Burns School of Medicine and Pacific Health Research and Education Institute, Honolulu, Hawaii. FAU - Gillman, Matthew W AU - Gillman MW AD - U.S. Preventive Services Task Force, current or former member; Division of Chronic Disease Across the Lifecourse, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts; Environmental Influences on Child Health Outcomes Program, Office of the Director, NIH, Rockville, Maryland. FAU - Mabry-Hernandez, Iris R AU - Mabry-Hernandez IR AD - Center for Evidence and Practice Improvement, Agency for Healthcare Research and Quality, Rockville, Maryland. FAU - Silverstein, Michael AU - Silverstein M AD - U.S. Preventive Services Task Force, current or former member; Department of Pediatrics, Boston University School of Medicine, Boston, Massachusetts. FAU - Chou, Roger AU - Chou R AD - Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, Oregon. FAU - Lozano, Paula AU - Lozano P AD - Kaiser Permanente Washington Health Research Institute, Seattle, Washington. FAU - Calonge, B Nedrow AU - Calonge BN AD - U.S. Preventive Services Task Force, current or former member; The Colorado Trust, Denver, Colorado. FAU - Wolff, Tracy A AU - Wolff TA AD - Center for Evidence and Practice Improvement, Agency for Healthcare Research and Quality, Rockville, Maryland. FAU - Grossman, David C AU - Grossman DC AD - U.S. Preventive Services Task Force, current or former member; Kaiser Permanente Washington Health Research Institute, Seattle, Washington; Department of Health Services and Pediatrics, University of Washington, Seattle, Washington. LA - eng PT - Journal Article PL - Netherlands TA - Am J Prev Med JT - American journal of preventive medicine JID - 8704773 SB - IM MH - Adolescent MH - Advisory Committees/*standards MH - Child MH - *Child Health MH - Child Health Services/standards MH - Evidence-Based Medicine/*methods/standards MH - Humans MH - Preventive Health Services/*standards MH - United States EDAT- 2017/12/20 06:00 MHDA- 2018/08/01 06:00 CRDT- 2017/12/20 06:00 PHST- 2017/04/26 00:00 [received] PHST- 2017/06/29 00:00 [revised] PHST- 2017/08/22 00:00 [accepted] PHST- 2017/12/20 06:00 [entrez] PHST- 2017/12/20 06:00 [pubmed] PHST- 2018/08/01 06:00 [medline] AID - S0749-3797(17)30478-6 [pii] AID - 10.1016/j.amepre.2017.08.023 [doi] PST - ppublish SO - Am J Prev Med. 2018 Jan;54(1S1):S63-S69. doi: 10.1016/j.amepre.2017.08.023.