PMID- 29254569
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180202
LR  - 20180202
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 999
DP  - 2018 Jan 25
TI  - Homochiral porous organic cage used as stationary phase for open tubular 
      capillary electrochromatography.
PG  - 169-175
LID - S0003-2670(17)31299-0 [pii]
LID - 10.1016/j.aca.2017.11.021 [doi]
AB  - Porous organic molecular cages, as a new type of porous materials, have in recent 
      years attracted a tremendous amount of attention for their potential 
      applications. However, to the best of our knowledge, there has been no attempt to 
      utilize porous organic molecular cages as stationary phases in capillary 
      electrochromatography (CEC). We report herein the use of a homochiral porous 
      organic cage (POC) (CC3-R) as a stationary phase in open tubular capillary 
      electrochromatography (OT-CEC) for the separation of chiral compounds and 
      positional isomers. The column was fabricated using CC3-R as the stationary phase 
      by a static coating method. Separation of furoin, benzoin, and alprenlol were 
      achieved on the CC3-R coated column, with the highest resolution value 
      (R(s) = 3.35) for the separation of benzoin. The influences of pH and buffer 
      concentration on separation have been investigated. Besides, the CC3-R column 
      also exhibited good selectivity for the separation of positional isomers, 
      including those of nitrophenols, phenylenediamines, aminophenols, and ionones. 
      The run-to-run (n = 5), day-to-day (n = 5), column-to-column (n = 3), and 
      batch-to-batch (n = 3) relative standard deviations (RSDs) for the analyte 
      migration time were in the range of 0.5-1.5%, 0.2-1.8%, 1.2-2.1% and 1.5-2.8%, 
      respectively. The RSDs for the migration time and enantioselectivity of the 
      analyte were less than 5.9% and 2.2% (inter-day, n = 5) after a week of 
      continuous use. This work also indicates that porous organic molecular materials 
      are promising for enantioseparation in CEC and look set to become more attractive 
      in separation science.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Zhang, Jun-Hui
AU  - Zhang JH
AD  - Department of Chemistry, Yunnan Normal University, Kunming 650500, PR China.
FAU - Zhu, Peng-Jing
AU  - Zhu PJ
AD  - Department of Chemistry, Yunnan Normal University, Kunming 650500, PR China.
FAU - Xie, Sheng-Ming
AU  - Xie SM
AD  - Department of Chemistry, Yunnan Normal University, Kunming 650500, PR China.
FAU - Zi, Min
AU  - Zi M
AD  - Department of Chemistry, Yunnan Normal University, Kunming 650500, PR China.
FAU - Yuan, Li-Ming
AU  - Yuan LM
AD  - Department of Chemistry, Yunnan Normal University, Kunming 650500, PR China. 
      Electronic address: yuan_limingpd@126.com.
LA  - eng
PT  - Journal Article
DEP - 20171114
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
OTO - NOTNLM
OT  - CC3-R
OT  - Chiral separation
OT  - Open tubular capillary electrochromatography
OT  - Porous organic cages
EDAT- 2017/12/20 06:00
MHDA- 2017/12/20 06:01
CRDT- 2017/12/20 06:00
PHST- 2017/08/01 00:00 [received]
PHST- 2017/11/06 00:00 [revised]
PHST- 2017/11/10 00:00 [accepted]
PHST- 2017/12/20 06:00 [entrez]
PHST- 2017/12/20 06:00 [pubmed]
PHST- 2017/12/20 06:01 [medline]
AID - S0003-2670(17)31299-0 [pii]
AID - 10.1016/j.aca.2017.11.021 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2018 Jan 25;999:169-175. doi: 10.1016/j.aca.2017.11.021. Epub 
      2017 Nov 14.