PMID- 29255205
OWN - NLM
STAT- MEDLINE
DCOM- 20180807
LR  - 20240327
IS  - 2055-1010 (Electronic)
IS  - 2055-1010 (Linking)
VI  - 27
IP  - 1
DP  - 2017 Dec 18
TI  - Associations between self-rated health, sickness behaviour and inflammatory 
      markers in primary care patients with allergic asthma: a longitudinal study.
PG  - 67
LID - 10.1038/s41533-017-0068-0 [doi]
LID - 67
AB  - Allergic asthma is a chronic inflammatory disorder associated with elevated 
      levels of immunoglobulin E (IgE), serum eosinophilic cationic protein (S-ECP), 
      plasma eosinophil-derived neurotoxin (P-EDN) and fraction of exhaled nitric oxide 
      (F(E)NO). Poor self-rated health and sickness behaviour has repeatedly been 
      associated with inflammatory markers, but the nature of this relationship in 
      chronic inflammatory disease is not known. Likewise, such findings largely rely 
      on cross-sectional investigations. Self-rated health (How would you rate your 
      general state of health?), sickness behaviour (mean rating of satisfaction with 
      energy, sleep, fitness, appetite and memory), IgE, S-ECP, P-EDN, and F(E)NO were 
      assessed in 181 non-smoking primary care patients with asthma in a 1-year 
      longitudinal study. Associations between repeated measurements were calculated 
      using mixed regression models and Spearman's correlations for change scores. Poor 
      self-rated health was associated with high levels of seasonal IgE (p = 0.05) and 
      food IgE (p = 0.04), but not total IgE or inflammatory markers. An increase over 
      1 year in perennial IgE was associated with a worsening of self-rated health 
      (rho = 0.16, p = 0.04). Poor self-rated health was associated with more pronounced 
      sickness behaviour (p < 0.001), and a worsening in sickness behaviour was 
      associated with a worsening of self-rated health over time (rho = 0.21, p = 0.007). 
      The study corroborates the importance of sickness behaviour as a determinant of 
      self-rated health by showing that these factors co-vary over a 1-year period in a 
      group of patients with allergic asthma. The importance of specific IgE for 
      perceived health in primary care patients with mild to moderate asthma needs 
      further investigation.
FAU - Lodin, Karin
AU  - Lodin K
AD  - Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 
      Stockholm, Sweden. karin.lodin@ki.se.
AD  - Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden. 
      karin.lodin@ki.se.
FAU - Lekander, Mats
AU  - Lekander M
AD  - Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
AD  - Stress Research Institute, Stockholm University, Stockholm, Sweden.
FAU - Syk, Jorgen
AU  - Syk J
AD  - Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 
      Stockholm, Sweden.
AD  - Centre for Allergy Research, Karolinska Institute, Stockholm, Sweden.
AD  - Academic Primary Health Care Centre, Stockholm, Sweden.
FAU - Alving, Kjell
AU  - Alving K
AD  - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
FAU - Andreasson, Anna
AU  - Andreasson A
AD  - Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 
      Stockholm, Sweden.
AD  - Stress Research Institute, Stockholm University, Stockholm, Sweden.
AD  - Department of Psychology, Macquarie University, North Ryde, Australia.
LA  - eng
PT  - Journal Article
DEP - 20171218
PL  - England
TA  - NPJ Prim Care Respir Med
JT  - NPJ primary care respiratory medicine
JID - 101631999
RN  - 0 (Biomarkers)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.- (Eosinophil-Derived Neurotoxin)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
SB  - IM
MH  - Adult
MH  - Asthma/*physiopathology
MH  - Biomarkers/blood
MH  - Eosinophil Cationic Protein/blood
MH  - Eosinophil-Derived Neurotoxin/blood
MH  - Exhalation
MH  - Female
MH  - *Health Status
MH  - Humans
MH  - *Illness Behavior
MH  - Immunoglobulin E/blood
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/analysis
MH  - *Self Report
MH  - Young Adult
PMC - PMC5735192
COIS- K.A. is a former employee of Aerocrine, and has received research support from 
      this company and from Thermo Fisher Scientific. J.S. has received research 
      support from Aerocrine. The remaining authors declare no competing financial 
      interests.
EDAT- 2017/12/20 06:00
MHDA- 2018/08/08 06:00
PMCR- 2017/12/18
CRDT- 2017/12/20 06:00
PHST- 2017/07/18 00:00 [received]
PHST- 2017/11/23 00:00 [accepted]
PHST- 2017/11/17 00:00 [revised]
PHST- 2017/12/20 06:00 [entrez]
PHST- 2017/12/20 06:00 [pubmed]
PHST- 2018/08/08 06:00 [medline]
PHST- 2017/12/18 00:00 [pmc-release]
AID - 10.1038/s41533-017-0068-0 [pii]
AID - 68 [pii]
AID - 10.1038/s41533-017-0068-0 [doi]
PST - epublish
SO  - NPJ Prim Care Respir Med. 2017 Dec 18;27(1):67. doi: 10.1038/s41533-017-0068-0.