PMID- 29255606
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240327
IS  - 2050-750X (Print)
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 5
IP  - 36
DP  - 2017 Sep 28
TI  - Enhanced cell uptake of fluorescent drug-loaded nanoparticles via an implantable 
      photothermal fibrous patch for more effective cancer cell killing.
PG  - 7504-7511
LID - 10.1039/C7TB01142C [doi]
AB  - Great efforts have been devoted to effective delivery of therapeutics into cells 
      for cancer therapy. The exploration of nanoparticle based drug delivery systems 
      (DDSs) faces daunting challenges in low efficacy of intracellular delivery. 
      Herein, a localized drug delivery device consisting of photoluminescent 
      mesoporous silica nanoparticles (PLMSNs) and photothermal fibrous matrix was 
      investigated. Specifically, PLMSNs modified with a pH-sensitive polydopamine 
      (PDA) 'gatekeeper' served as a doxorubicin (DOX) carrier and could release DOX 
      once the PLMSNs were up-taken by the cancer cells. The PLMSNs were 
      electrostatically assembled on the surface of electrospun biodegradable 
      poly(epsilon-caprolactone)/gelatin fibrous mesh incorporated with photothermal carbon 
      nanoparticles (CNPs), leading to an implantable patch used as localized delivery 
      platform. Comparing to free particulate DDSs, this implantable composite patch 
      device was found to significantly enable superior cell up-taking effect and 
      consequently enhance in-vitro therapeutic efficacy against tumor cells. Namely, 
      under near infrared irradiation, the photothermal effect of CNPs in the 
      implantable patch weakens the electrostatic interaction between the PLMSNs and 
      poly(epsilon-caprolactone)/gelatin/CNP fibrous mesh, resulting in the controlled 
      release of the PLMSNs and subsequent internalization into the tumor cells for 
      more effective cancer cell killing. This implantable therapeutic device may 
      therefore inspire another way of developing localized cancer therapy.
FAU - Li, Yangyang
AU  - Li Y
AD  - State Key Laboratory of Silicon Materials, School of Materials Science and 
      engineering, Zhejiang University, Hangzhou, Zhejiang, P. R. China 310027.
FAU - Fu, Yike
AU  - Fu Y
AD  - State Key Laboratory of Silicon Materials, School of Materials Science and 
      engineering, Zhejiang University, Hangzhou, Zhejiang, P. R. China 310027.
FAU - Ren, Zhaohui
AU  - Ren Z
AD  - State Key Laboratory of Silicon Materials, School of Materials Science and 
      engineering, Zhejiang University, Hangzhou, Zhejiang, P. R. China 310027.
FAU - Li, Xiang
AU  - Li X
AD  - State Key Laboratory of Silicon Materials, School of Materials Science and 
      engineering, Zhejiang University, Hangzhou, Zhejiang, P. R. China 310027.
FAU - Mao, Chuanbin
AU  - Mao C
AD  - State Key Laboratory of Silicon Materials, School of Materials Science and 
      engineering, Zhejiang University, Hangzhou, Zhejiang, P. R. China 310027.
AD  - Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, 
      University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma, 73019-5300, 
      United States.
FAU - Han, Gaorong
AU  - Han G
AD  - State Key Laboratory of Silicon Materials, School of Materials Science and 
      engineering, Zhejiang University, Hangzhou, Zhejiang, P. R. China 310027.
LA  - eng
GR  - R21 CA195607/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20170907
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
PMC - PMC5730969
MID - NIHMS905013
EDAT- 2017/12/20 06:00
MHDA- 2017/12/20 06:01
PMCR- 2018/09/28
CRDT- 2017/12/20 06:00
PHST- 2017/12/20 06:00 [entrez]
PHST- 2017/12/20 06:00 [pubmed]
PHST- 2017/12/20 06:01 [medline]
PHST- 2018/09/28 00:00 [pmc-release]
AID - 10.1039/C7TB01142C [doi]
PST - ppublish
SO  - J Mater Chem B. 2017 Sep 28;5(36):7504-7511. doi: 10.1039/C7TB01142C. Epub 2017 
      Sep 7.